Abstract: According to the present disclosure, there is provided a method of producing an immune cell that responds to a cancer-associated antigen, the method including stimulating an immune cell with an antigen contained in a pluripotent stem cell. In addition, according to the present disclosure, there is provided a method of producing an immune cell that responds to a cancer-associated antigen, the method including stimulating an immune cell with at least part of a pluripotent stem cell. In addition, according to the present disclosure, there is provided a method of amplifying response of an immune cell to a cancer-associated antigen, the method including stimulating an immune cell with an antigen contained in a pluripotent stem cell. In addition, according to the present disclosure, there is provided a method of amplifying response of an immune cell to a cancer-associated antigen, the method including stimulating an immune cell with a pluripotent stem cell.

Abstract: According to the present disclosure, there is provided a method for producing stem cells, which includes applying a phosphate to blood cells and inducing stem cells from the blood cells. The phosphate may be an intermediate product or a final product in a non-mevalonate pathway. The phosphate may be (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.

Abstract: According to the present disclosure, there is provided a method for culturing cells into which a reprogramming factor is introduced including culturing cells into which a reprogramming factor is introduced; and recovering all cells into which the reprogramming factor is introduced and seeding and passaging at least part of the recovered cells in a medium. In addition, there is provided a method for culturing cells into which a reprogramming factor is introduced, including culturing cells into which a reprogramming factor is introduced; and inducing somatic cells different from pluripotent stem cells without passaging the cells into which the reprogramming factor is introduced.

Abstract: A valve including a case 3, a tube 1 disposed in the case 3, a hinge fulcrum 4 disposed in the case 3, a contact member 5 connected to the hinge fulcrum 4 and capable of coming into contact with the tube 1, and a driving device 10 configured to apply a non-contact force to the contact member 5 from outside of the case 3 and change a contact force that is applied to the tube 1 by the contact member 5 to change an inner diameter of the tube 1.

Abstract: Provided are a pharmaceutical composition or a pharmaceutical composition raw material, which contains supernatant from a culture medium used during culture to induce pluripotent stem cells.

Abstract: According to the present disclosure, there is provided a method for screening a substance, which includes inducing pluripotent stem cells from somatic cells of a subject; inducing differentiated cells from the pluripotent stem cells; adding a substance to the differentiated cells and culturing the differentiated cells; and determining whether or not to administering or applying the substance to the subject based on a response of the differentiated cells to the substance.

Abstract: A cell processing system comprising an enclosure 601, an outer enclosure 701 that envelops the enclosure 601, an intake air purification filter 602 provided in the enclosure 601, that purifies gas that has been drawn in from outside the enclosure 601, a circulating apparatus, inside the outer enclosure 701, that circulates gas inside and outside the enclosure 601 in such a manner that gas in the outer enclosure 701 is drawn into the enclosure 601 through the intake air purification filter 602 and gas inside the enclosure 601 is discharged into the outer enclosure 701, and a cell processing apparatus for processing of cells, disposed inside the enclosure 601.

Abstract: Provided are a pharmaceutical composition or a pharmaceutical composition raw material, which contains supernatant from a culture medium used during culture to induce pluripotent stem cells.

Abstract: A cell culture equipment comprising a culture component permeable member 10 that is permeable to culture components, a culture vessel 30 that covers one side of the culture component permeable member 10 and holds a cell-containing medium, and a medium holding vessel 40 that covers the other side of the culture component permeable member 10 and holds a medium.

Abstract: A cell processing system comprising an enclosure 601, an outer enclosure 701 that envelops the enclosure 601, an intake air purification filter 602 provided in the enclosure 601, that purifies gas that has been drawn in from outside the enclosure 601, a circulating apparatus, inside the outer enclosure 701, that circulates gas inside and outside the enclosure 601 in such a manner that gas in the outer enclosure 701 is drawn into the enclosure 601 through the intake air purification filter 602 and gas inside the enclosure 601 is discharged into the outer enclosure 701, and a cell processing apparatus for processing of cells, disposed inside the enclosure 601.

Abstract: According to the present disclosure, there is provided a method for producing oligodendrocytes and progenitor cells thereof, comprising introducing inducers including a combination of OLIG and SOX or a combination of OLIG and NKX into iPS or ES cells. According to the present disclosure, there is also provided a method for producing oligodendrocytes and progenitor cells thereof, comprising introducing inducers including OLIG, SOX, ASCL, and NKX into somatic cells.

Abstract: A stem cell production system provided with a preintroduction cell-feeding solution channel 20 through which a solution containing cells passes, an induction factor-feeding solution mechanism 21 for feeding a pluripotency induction factor to the preintroduction cell-feeding solution channel 20, a factor introduction device 30 connected to the preintroduction cell-feeding solution channel 20 for making cells with induction factor introduced by introducing the pluripotency induction factor into the cells, a cell mass-making device 40 for making multiple cell masses comprising stem cells by culturing the cells with induction factor introduced, and a packaging device 100 for sequentially packaging each of the multiple cell masses.

Abstract: A valve including a case 3, a tube 1 disposed in the case 3, a hinge fulcrum 4 disposed in the case 3, a contact member 5 connected to the hinge fulcrum 4 and capable of coming into contact with the tube 1, and a driving device 10 configured to apply a non-contact force to the contact member 5 from outside of the case 3 and change a contact force that is applied to the tube 1 by the contact member 5 to change an inner diameter of the tube 1.

Abstract: The present invention provides a culturing system and method for culturing cells that can culture cells in parallel. The culturing system comprises a cell storage 10 configured to store cells, a plurality of culture apparatuses 20, and a distribution flow path 30 configured to distribute the cells from the cell storage 10 to the culture apparatuses 20, in which each of the culture apparatuses 20 comprises a plurality of culture vessels 21, a supply flow path 22 configured to selectively supply a fluid from the distribution flow path 30 to the culture vessels 21, and a connection flow path 23 configured to connect the culture vessels 21; the culture vessels 21 are connected in series with the connection flow path 23 in each of the culture apparatuses 20; and the supply flow path 22 is configured to selectively supply the fluid to the culture vessels so that the cells are sequentially transferred among the culture vessels 21 through the connection flow path 23 in each of the culture apparatuses 20.

Abstract: A method for producing nerve cells includes introducing NGN1 as a differentiation factor into stem cells. A method for producing nerve cells includes introducing only NeuroD4 as a differentiation factor into stem cells. A method for producing motor neurons includes introducing NGN2, ISL2, and LHX4 as differentiation factors into stem cells. A method for producing motor neurons includes introducing NGN1, ISL2, and LHX4 as differentiation factors into stem cells. A method for producing motor neurons includes introducing NeuroD4, ISL2, and LHX4 as differentiation factors into stem cells.

Abstract: A stem cell manufacturing system for manufacturing stem cells from somatic cells includes: one or more closed production device(s) configured to produce stem cells from somatic cells; one or more drive device(s) configured to be connected with the production device(s) and drive the production device(s) in such a manner as to maintain the production device(s) in an environment suitable for producing stem cells; one or more cryopreservation device(s) configured to cryopreserve the produced stem cells; a first memory device configured to store whether or not somatic cells have been introduced to the production device(s), as a first state; a second memory device configured to store whether or not the production device(s) is/are connected with the drive device(s), as a second state; and a third memory device configured to store whether or not the produced stem cells can be placed in the cryopreservation device(s), as a third state.

Abstract: According to the present disclosure, there is provided a method for producing stem cells including: preparing somatic cells; preparing a chimeric virus including a virus-derived genomic RNA harboring an inducer RNA that induces somatic cells into stem cells and a virus-derived envelope surrounding the genomic RNA, wherein the genomic RNA and the envelope are derived from different viruses; and introducing the inducer RNA into the somatic cells using the chimeric virus.

Abstract: A pump is provided that includes a tube 1, tube rotors 21A, 21B, and 21C in contact with the tube 1, a case 3 containing the tube 1 and tube rotors 21A, 21B, and 21C, and a drive apparatus 10 that rotates the tube rotors 21A, 21B, and 21C from outside the case 3 without contacting the tube rotors 21A, 21B, and 21C.

Abstract: According to the present disclosure, there is provided a method for culturing factor-introduced cells, the method including culturing factor-introduced cells and recovering the factor-introduced cells and seeding at least part of the recovered cells in a medium for seeding. In addition, there is provided a method for culturing factor-introduced cells, the method including culturing factor-introduced cells and inducing the factor-introduced cells to somatic cells different from pluripotent stem cells without passaging.

Abstract: An solution transfer device comprises a pump 60 and a substrate 70. The pump 60 comprises a tube 1 for transferring a solution; tube rotors 21A, 21B, 21C, which contact the tube 1; and a driver 10 for transferring a solution within the tube 1 by rotating the tube rotors 21A, 21B, 21C without contacting the tube rotors 21A, 21B, 21C. The substrate 70 is provided with a solution-transferring flow path that is connected to the tube 1 of the pump 60.