Patents Assigned to i-STAT Corporation
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Patent number: 7918978Abstract: A sensing device includes a sensing surface, and a matrix overlaying the sensing surface. The sensing device includes a photoformed membrane overlaying at least a portion of the matrix. The photoformed membrane includes a directly photoformed organosiloxane polymer that is substantially permeable to gaseous molecules and substantially impermeable to non-gaseous molecules and ions.Type: GrantFiled: July 12, 2006Date of Patent: April 5, 2011Assignee: I-STAT CorporationInventors: Margot Leanne McCann, Sandra Kay Shaw, Karl John Anthony Underwood, Harvey Eric Rabe
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Publication number: 20100068097Abstract: The invention is directed to fluid-containing pouches and to methods for forming fluid-containing pouches. In one embodiment, the invention is to a fluid-containing pouch, comprising first and second opposing sheets, and a fluid (e.g., a calibrant fluid, a reactant fluid or a wash fluid) disposed between the first and second opposing sheets. The first sheet and the second sheet have a substantially liquid and gas impermeable perimeter seal. The sheets may be sealed, for example, by one or more of heat crimping, pressure crimping, heat and pressure crimping, ultrasonic welding, metal-to-metal welding or laser welding. Fluid-containing pouches sealed according to the disclosed methods and apparatuses show substantially improvement in terms of reduced gas exchange, notably CO2 pressurization levels.Type: ApplicationFiled: September 15, 2008Publication date: March 18, 2010Applicant: i-STAT CorporationInventors: Rhonda ADE, Steven R. Breeze, Philippe Poirier, Bill Dicke
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Publication number: 20090065368Abstract: The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements.Type: ApplicationFiled: July 1, 2008Publication date: March 12, 2009Applicant: i-STAT CorporationInventors: Graham Davis, Imants R. Lauks, Chao Lin, Cary James Miller
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Patent number: 7419821Abstract: The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements.Type: GrantFiled: March 5, 2002Date of Patent: September 2, 2008Assignee: I-Stat CorporationInventors: Graham Davis, Imants R. Lauks, Chao Lin, Cary James Miller
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Publication number: 20080065420Abstract: A sample analysis and medical data acquisition system for patient management includes a first user interface (UI) display module for displaying a medical chart page that includes selectable items associated with patient management. The first UI display module displays a set of medical delivery systems associated with a selectable medical delivery selection item, from which a medical delivery system is chosen. The system includes a second UI display module, in communication with the first UI display module, for displaying parameter fields for entry of operation data associated with the chosen medical delivery system. Medical data is captured from a patient by an analyzer configured to perform analysis of samples from the patient. The medical data is analyzed in accordance with entered operation data. The system includes an analysis display module, in communication with at least the first UI display module, for displaying sample analysis results.Type: ApplicationFiled: July 13, 2007Publication date: March 13, 2008Applicant: i-STAT CorporationInventors: Jody TIRINATO, Mark Maund, Paul Machiaverna, Paul Gibson, Gary Vandersleen, Rosa Ibanez, Lyudmila Zaltsman, Michael Zelin
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Patent number: 7263501Abstract: A system and method are disclosed for controlling an inventory of a plurality of point-of-care diagnostic devices. The plurality of devices includes at least one type of device. Each device is configured to perform at least one sample analysis. Each device has a usable lifetime. The inventory includes a main inventory and at least one subinventory. The inventory control system comprises a data input interface for entering data associated with the devices and a data output interface for displaying data associated with the devices. A memory stores data associated with the devices and stores steps of a computer program to automatically update the current number of devices in the at least one subinventory in response to an occurrence of an event that causes a change in the current number of devices in the at least one subinventory. The inventory control system comprises a processor for accessing the memory to execute the computer program.Type: GrantFiled: March 11, 2003Date of Patent: August 28, 2007Assignee: I-Stat CorporationInventors: Jody Ann Tirinato, Michael P. Zelin, Paul Andrew Gibson, Lyudmila Zaltsman, Graham Davis
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Publication number: 20070015977Abstract: A sensing device includes a sensing surface, and a matrix overlaying the sensing surface. The sensing device includes a photoformed membrane overlaying at least a portion of the matrix. The photoformed membrane includes a directly photoformed organosiloxane polymer that is substantially permeable to gaseous molecules and substantially impermeable to non-gaseous molecules and ions.Type: ApplicationFiled: July 12, 2006Publication date: January 18, 2007Applicant: I-STAT CorporationInventors: Margot McCann, Sandra Shaw, Karl Underwood, Harvey Rabe
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Patent number: 7074610Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: GrantFiled: August 30, 2001Date of Patent: July 11, 2006Assignee: i-Stat CorporationInventors: Stephen N. Cozzette, Graham Davis, Jeanne A. Itak, Imants R. Lauks, Randall M. Mier, Sylvia Piznik, Nicolaas Smit, Susan J. Steiner, Paul Van Der Werf, Henry J. Wieck
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Publication number: 20060046275Abstract: A BUN (blood urea nitrogen) sensor containing immobilized carbonic anhydrase and immobilized urease for the in vitro detection of urea nitrogen in blood and biological samples with improved performance and precision characteristics.Type: ApplicationFiled: September 1, 2005Publication date: March 2, 2006Applicant: i-STAT CorporationInventors: G. Collier, Eric Brouwer, Anjulia Wong
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Patent number: 6750053Abstract: This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.Type: GrantFiled: November 15, 2000Date of Patent: June 15, 2004Assignee: i-STAT CorporationInventors: Cindra A. Widrig Opalsky, David Opalsky, Andy Maczuszenko, Imants R. Lauks, Rhonda J. Cheadle
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Publication number: 20030170881Abstract: The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements.Type: ApplicationFiled: March 5, 2002Publication date: September 11, 2003Applicant: I-STAT CorporationInventors: Graham Davis, Imants R. Lauks, Chao Lin, Cary James Miller
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Publication number: 20020177958Abstract: A sample analyzing system includes at least one sensor located at least partially within a sample retaining area. In addition, the sensor has at least one edge defining a sample detection location. This sample detection location defines an area within which the sensor is capable of detecting a presence or an absence of the sample. The system analyzes sample data by first introducing the sample into the sample retaining area and then mixing a reagent with the sample to commence formation of a reagent product. After mixing and upon detecting the absence of the sample from the sample detection location by the at least one sensor, an edge of the sample is moved past an edge of the at least one sensor and into the sample detection location. Then, upon detecting the presence of the sample in the sample detection location by the at least one sensor, the edge of the sample is moved past the edge of the at least one sensor and out of the sample detection location.Type: ApplicationFiled: July 8, 2002Publication date: November 28, 2002Applicant: i-STAT CorporationInventors: Cindra A. Widrig Opalsky, David Opalsky, Andy Maczuszenko, Imants R. Lauks
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Patent number: 6438498Abstract: A sample analyzing system includes at least one sensor located at least partially within a sample retaining area. In addition, the sensor has at least one edge defining a sample detection location. This sample detection location defines an area within which the sensor is capable of detecting a presence or an absence of the sample. The system analyzes sample data by first introducing the sample into the sample retaining area and then mixing a reagent with the sample to commence formation of a reagent product. After mixing and upon detecting the absence of the sample from the sample detection location by the at least one sensor, an edge of the sample is moved past an edge of the at least one sensor and into the sample detection location. Then, upon detecting the presence of the sample in the sample detection location by the at least one sensor, the edge of the sample is moved past the edge of the at least one sensor and out of the sample detection location.Type: GrantFiled: March 17, 2000Date of Patent: August 20, 2002Assignee: I-Stat CorporationInventors: Cindra A. Widrig Opalsky, David Opalsky, Andy Maczuszenko, Imants R. Lauks
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Publication number: 20020090738Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: ApplicationFiled: August 30, 2001Publication date: July 11, 2002Applicant: i-STAT CorporationInventors: Stephen N. Cozzette, Graham Davis, Imants R. Lauks, Randall M. Mier, Sylvia Piznik, Nicolaas Smit, Paul Van Der Werf, Henry J. Wieck
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Patent number: 6379883Abstract: A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.Type: GrantFiled: December 21, 2000Date of Patent: April 30, 2002Assignee: i-STAT CorporationInventors: Graham Davis, Chao Lin, Imants R. Lauks, Raymond J. Pierce
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Patent number: 6306594Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: GrantFiled: November 17, 1998Date of Patent: October 23, 2001Assignee: i-STAT CorporationInventors: Stephen N. Cozzette, Graham Davis, Imants R. Lauks, Randall M. Mier, Sylvia Piznik, Nicolaas Smit, Paul Van der Werf, Henry J. Wieck
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Patent number: 6030827Abstract: A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.Type: GrantFiled: January 23, 1998Date of Patent: February 29, 2000Assignee: i-Stat CorporationInventors: Graham Davis, Chao Lin, Imants R. Lauks, Raymond J. Pierce
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Patent number: 5837454Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: GrantFiled: June 7, 1995Date of Patent: November 17, 1998Assignee: i-STAT CorporationInventors: Stephen N. Cozzette, Graham Davis, Imants R. Lauks, Randall M. Mier, deceased, Sylvia Piznik, Nicolaas Smit, Paul Van Der Werf, Henry J. Wieck, Susan Steiner, Jeanne Itak
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Patent number: 5837446Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over he dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: GrantFiled: June 7, 1995Date of Patent: November 17, 1998Assignee: i-STAT CorporationInventors: Stephen N. Cozzette, Graham Davis, Jeanne Itak, Imants R. Lauks, Sylvia Piznik, Nicolaas Smit, Susan Steiner, Paul Van Der Werf, Henry J. Wieck, Randall M. Mier, deceased
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Patent number: 5821399Abstract: A method for automatic fluid flow compensation in disposable fluid analysis sensing devices is disclosed. The method is designed to keep the test conditions from sample to sample substantially unchanged. This is accomplished by using information about the preceding and/or current test measurements to automatically offset parameter variations of the disposable devices and the reading apparatus caused by manufacturing tolerances, wear of the mechanical parts, fluid viscosity differences and others. At each consecutive test measurement the method uses a compensation of the position of the actuating element to offset the difference between the previous test measurement and a factory pre-specified value. The method and system result, over the lifetime of the instrument, in a substantially unchanged flow of the analyzed fluid and reduction of the influence of a variety of external factors on the test measurements.Type: GrantFiled: January 16, 1996Date of Patent: October 13, 1998Assignee: I-Stat CorporationInventor: Michael P. Zelin