Patents Assigned to i2 PHARMACEUTICALS, INC.
  • Anti-surrogate light chain antibodies
    Patent number: 10858448
    Abstract: The present invention concerns anti-surrogate light chain antibodies and their uses. In particular, the present invention concerns anti-VpreB1 antibodies and their uses.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: December 8, 2020
    Assignee: I2 PHARMACEUTICALS, INC.
    Inventor: Lawrence Horowitz
  • Sur-binding proteins against ERBB3
    Patent number: 10300140
    Abstract: Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to ErbB3 and aspects relating to such constructs.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: May 28, 2019
    Assignee: I2 PHARMACEUTICALS, INC.
    Inventors: Ramesh R. Bhatt, Pamela K. Foreman, Lawrence C. Horowitz, Michael Horowitz, Medini Gore, Phil Kobel
  • Constructs and libraries comprising antibody surrogate light chain sequences
    Patent number: 10214580
    Abstract: The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: February 26, 2019
    Assignee: I2 PHARMACEUTICALS, INC.
    Inventors: Ramesh Bhatt, Lawrence Horowitz, Li Xu
  • Construction of diverse synthetic peptide and polypeptide libraries
    Patent number: 10216897
    Abstract: The present invention concerns the design and construction of diverse peptide and polypeptide libraries. In particular, the invention concerns methods of analytical database design for creating datasets using multiple relevant parameters as filters, and methods for generating sequence diversity by directed multisyntheses oligonucleotide synthesis. The present methods enable the reduction of large complex annotated databases to simpler datasets of related sequences, based upon relevant single or multiple key parameters that can be individually directly defined. The methods further enable the creation of diverse libraries based on this approach, using multisynthetic collections of discrete and degenerate oligonucleotides to capture the diverse collection of sequences, or portions thereof.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: February 26, 2019
    Assignee: I2 PHARMACEUTICALS, INC.
    Inventors: Lawrence Horowitz, Ramesh Bhatt, Aaron L. Kurtzman
  • Neutralizing molecules to influenza viruses
    Patent number: 10017561
    Abstract: The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the neutralizing antibodies produced. In particular, the invention concerns neutralizing antibodies against various influenza A virus subtypes, and methods and means for making such antibodies.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: July 10, 2018
    Assignee: I2 PHARMACEUTICALS, INC.
    Inventors: Lawrence Horowitz, Ramesh Bhatt, Arun Kashyap
  • Surrogate binding proteins which bind DR4 and/or DR5
    Patent number: 9975956
    Abstract: Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to DR4 and/or DR5 and aspects relating to such constructs and their use.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: May 22, 2018
    Assignee: i2 PHARMACEUTICALS, INC.
    Inventors: Arun K. Kashyap, Ramesh R. Bhatt, Michael Horowitz, Lawrence Horowitz, Sihong Zhou, Ryann E. O'Neil, Charles H. Hannum, Aaron L. Kurtzman, Li Xu