Patents Assigned to Iatron Laboratories, Inc.
  • Publication number: 20040266018
    Abstract: A hydrogen-flame photometric analyzer for a thin-layer chromatograph, comprising
    Type: Application
    Filed: July 19, 2004
    Publication date: December 30, 2004
    Applicant: IATRON LABORATORIES INC.
    Inventors: Minoru Ogasawara, Kyoko Tsuruta
  • Patent number: 6787325
    Abstract: Provided are novel complexes containing a crosslinked avidin, an analyzing method and analyzing reagents and kits whereby a compound to be analyzed can be quickly, conveniently and accurately analyzed while taking advantage of the avidin-biotin reaction. The complexes contain at least two homogeneous or heterogeneous biotin-introduced products and one crosslinked avidin sandwiched therebetween. In the analyzing method, the homogeneous or heterogeneous biotin-introduced products and the crosslinked avidin are used. The analyzing reagent contains the crosslinked avidin. The analyzing kit contains the crosslinked avidin and a biotinylating agent.
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: September 7, 2004
    Assignees: Iatron Laboratories, Inc., Kikkoman Corporation
    Inventors: Kazuyuki Sugiyama, Nobuhiro Hoshino, Hiroki Tatsumi, Satoshi Fukuda
  • Patent number: 6569634
    Abstract: This invention relates to a method for immunologically measuring human thymidylate synthase with an anti-human thymidylate synthase antibody, wherein as the antibody, at least an anti-human thymidylate synthase polyclonal antibody immobilized on an insoluble matrix is used; a method for evaluating sensitivity of cancer cells to a fluoropyrimidine antitumor drug from the results of the measurement by the measuring method; and a human thymidylate synthase measuring kit comprising an insoluble matrix with at least one anti-human thymidylate synthase polyclonal antibody immobilized thereon. By a simple immunological measuring method, human TS in a sample can be measured with high sensitivity.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: May 27, 2003
    Assignees: Taiho Pharmaceutical Co., Ltd., Iatron Laboratories Inc.
    Inventors: Nobuhiro Hoshino, Takeshi Matsuya, Masakazu Fukushima, Hiroyuki Okabe
  • Patent number: 6143510
    Abstract: A method for quantitatively measuring analyte in an undiluted whole blood sample is disclosed which involves contacting an undiluted whole blood sample comprising the analyte with magnetically-responsive particles which comprise a first partner which is coated on a magnetically-responsive particulate insoluble carrier, wherein the first partner specifically binds to the analyte to form a first complex of insoluble carrier-first partner-analyte, separating the resulting first complex from the undiluted whole blood sample, thereafter contacting the resulting separated first complex with a second partner which is labelled with a detectable marker and which specifically binds to the analyte to form a second complex of insoluble carrier-first partner-analyte-second partner, and separating the resulting second complex from unbound second partner by washing, and thereafter detecting the marker in the second complex to quantitatively measure the analyte in the undiluted whole blood sample, and wherein the initial con
    Type: Grant
    Filed: March 29, 1996
    Date of Patent: November 7, 2000
    Assignee: Iatron Laboratories Inc.
    Inventors: Nobuhiro Hoshino, Michiko Kawamoto, Mitoshi Shimamoto
  • Patent number: 6132719
    Abstract: A monoclonal antibody which specifically reacts with D-monomer produced by digesting human fibrinogen with granulocyte elastase and D-domain containing digestion products produced by digesting human stabilized fibrin with granulocyte elastase, but does not react with fibrinogen, or fragment X, Y or E produced by digesting fibrinogen with granulocyte elastase is disclosed. The D-dimer or DD/E complex produced by digestion with granulocyte elastase in a sample from a living body can be analyzed without being interferred with fibrinogen, digestion products of fibrinogen with plasmin, or digestion products of stabilized fibrin with plasmin, using the monoclonal antibody.
    Type: Grant
    Filed: January 15, 1998
    Date of Patent: October 17, 2000
    Assignee: Iatron Laboratories, Inc.
    Inventors: Isao Kohno, Kimiko Inuzuka, Yumiko Ito, Ken Fukushi
  • Patent number: 5968756
    Abstract: The present invention provides such a measuring method of the CK isoform and a reagent therefor. Accordingly, the present invention provides a reagent for measuring creatine kinase (CK) activity comprising an antibody, wherein said antibody inhibits CK-M.sub.T subunit, but does not inhibit CK-M.sub.S subunit.The present invention also provides a method for measuring CK activity comprising determining an inhibition of CK of body fluids using a reagent for measuring CK activity, wherein said reagent comprises an antibody which inhibits CK-M.sub.T subunit, but does not inhibit CK-M.sub.S subunit.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: October 19, 1999
    Assignees: Unitika Ltd., Iatron Laboratories, Inc.
    Inventors: Tadao Suzuki, Tomoko Kamei, Mihoko Era, Hiroyuki Tsubota
  • Patent number: 5925570
    Abstract: A method and a reagent for highly accurate measuring of trace amount of metals in a sample of living body. The method and the reagent for measuring metals in a sample of living body includes:(1) a method for measuring metals in sample of living body, in which metals other than the objective metals of measurement are added to the measurement system to release the objective metals bonding to co-existing substances in the sample from the co-existing substances; and(2) a reagent for the measurement, in which metals other than the objective metals of the measurement are contained in a reagent for measuring metals in a sample of living body in order to release the objective metals bonding to the co-existing substances in the sample from the co-existing substances.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: July 20, 1999
    Assignee: Iatron Laboratories, Inc.
    Inventors: Kazuyoshi Nishidate, Hiroshi Suzuki, Youko Suzuki, Youko Koga
  • Patent number: 5888749
    Abstract: A first monoclonal antibody which specifically reacts with a human .alpha..sub.2 -plasmin inhibitor complex (PIC) and a human plasminogen; a second monoclonal antibody which reacts with PIC and also with a human .alpha..sub.2 -plasmin inhibitor; a third monoclonal antibody which reacts with PIC, but does not react with a human plasminogen and a human .alpha..sub.2 -plasmin inhibitor; hybridomas which secrete the first to third monoclonal antibodies, and an immunoassay using the first to third monoclonal antibodies.
    Type: Grant
    Filed: September 21, 1992
    Date of Patent: March 30, 1999
    Assignee: Iatron Laboratories, Inc.
    Inventors: Gilbu Soe, Isao Kohno, Mami Shiiba
  • Patent number: 5879888
    Abstract: A light emitting method of an acridinium ester, comprising reacting said acridinium ester and a superoxide anion, and a method of detecting a substance to be examined, comprising detecting a light emitted by reacting a superoxide anion with an acridinium ester used as a label are described. It is possible to carry out the reaction not under strongly alkaline conditions but around the neutral point and to generate strong luminescence which is stable over a long period of time.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: March 9, 1999
    Assignee: Iatron Laboratories, Inc.
    Inventors: Masuo Aizawa, Yoshihito Ikariyama, Eiry Kobatake, Minoru Ogasawara, Mitsunao Tanaka
  • Patent number: 5834227
    Abstract: A reagent for assaying creatine kinase, which contains glucokinase or hexokinase, glucose-6-phosphate dehydrogenase, adenosine 5'-diphosphate, creatine phosphate, oxidized nicotinamide adenine dinucleotide phosphate, magnesium salt, and glucose; and which comprises a first liquid reagent having a pH value of 7.5 to 10 and containing at least glucokinase and/or hexokinase, glucose-6-phosphate dehydrogenase, adenosine 5'-diphosphate and creatine phosphate, and a second liquid reagent having a pH value of 2 to 5 and containing at least oxidized nicotinamide adenine dinucleotide phosphate. The present reagent can be stably stored in the form of liquid for a long period of time at normal or low temperature in dark or light place. Therefore, it can be used without dissolution procedure after being preserved for a long term at the site of clinical examination and is also applicable to automatic analyzers.
    Type: Grant
    Filed: August 18, 1995
    Date of Patent: November 10, 1998
    Assignee: Iatron Laboratories, Inc.
    Inventors: Hiroyuki Tsubota, Reiko Shimada
  • Patent number: 5821068
    Abstract: A monoclonal antibody that reacts with a human soluble fibrin but not with a human fibrinogen; a hybridoma that secretes the above antibody; and a method of assaying a human soluble fibrin with the above antibody. It is possible to determine the amount of soluble fibrin in the plasma of a patient specifically, readily and rapidly by agglutination and EIA without being affected by plasma fibrinogen, plasmin-degradation product of fibrinogen, fibrin fragment, and plasmin-degradation product of stabilized fibrin even without pretreating the plasma sample.
    Type: Grant
    Filed: September 22, 1995
    Date of Patent: October 13, 1998
    Assignee: Iatron Laboratories, Inc.
    Inventors: Gilbu Soe, Isao Kohno, Kimiko Inuzuka, Yumiko Ito
  • Patent number: 5804394
    Abstract: The present invention provides such a measuring method of the CK isoform and a reagent therefor. Accordingly, the present invention provides a reagent for measuring creatine kinase (CK) activity comprising an antibody, wherein said antibody inhibits CK-M.sub.T subunit, but does not inhibit CK-M.sub.S subunit.The present invention also provides a method for measuring CK activity comprising determining an inhibition of CK of body fluids using a reagent for measuring CK activity, wherein said reagent comprises an antibody which inhibits CK-M.sub.T subunit, but does not inhibit CK-M.sub.S subunit.
    Type: Grant
    Filed: October 20, 1993
    Date of Patent: September 8, 1998
    Assignees: Unitika Ltd., Iatron Laboratories, Inc.
    Inventors: Tadao Suzuki, Tomoko Kamei, Mihoko Era, Hiroyuki Tsubota
  • Patent number: 5683889
    Abstract: The present invention relates to a reagent for measurement of magnesium ions utilizing a complex of magnesium ion with adenosine 5'-triphosphate as a substrate of glucokinase derived from bacteria of the genus Zymomonas. By using this reagent, enough measuring range to measure a magnesium ion in various samples such as biological fluids, foodstuffs, etc. can be accomplished and, at the same time, the measurement can be made with high precision and reliability even in a sample containing a magnesium ion in low concentration. Further, the reagent of the present invention is superior in operation property by reducing a dilution operation, and has sufficient performance for a routine method for determination of magnesium ions.
    Type: Grant
    Filed: September 23, 1993
    Date of Patent: November 4, 1997
    Assignees: Iatron Laboratories, Inc., Unitika, Ltd.
    Inventors: Hitoshi Kondou, Kazuhiko Nagata, Kazue Kawahara
  • Patent number: 5682232
    Abstract: A light-emission measuring apparatus which is capable of eliminating various secondary problems in addition to shutting off strong light from the external and preventing crosstalk. The light-emission measuring apparatus is equipped with a box-type carrier 9 having an open top surface and made to accommodate a microplate 7 comprising a plurality of wells. The box-type carrier is disposed to be movable horizontally. A light-obstruction plate having a light-receiving hole 11 is disposed above the box-type carrier to be movable vertically. The light-obstruction plate 5 is brought into tight contact with a circumference of the box-type carrier 9 to establish a black box when being moved downwardly. Further, the light-receiving hole 11 of the light-obstruction plate 5 has a cylindrical projecting bottom surface 12 so that its bottom surface side outer circumference comes into tight contact with a circumference 13 of an opening of a well top surface of the microplate 7.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: October 28, 1997
    Assignees: Precision System Science Co., Ltd., Iatron Laboratories, Inc.
    Inventors: Hideji Tajima, Nobuo Nagaoka, Minoru Ogasawara, Mitsunao Tanaka
  • Patent number: 5658915
    Abstract: An antibacterial agent characterized by containing a polyelectrolyte complex prepared by reacting a cationic polymer containing N.sup.+ atoms in repeating units thereof and an anionic polymer containing --COO.sup.-, --SO.sub.3.sup.-, or --PO.sub.3.sup.- groups in repeating units thereof, and an antibacterial material carrying the above polyelectrolyte complex on a carrier.
    Type: Grant
    Filed: August 25, 1995
    Date of Patent: August 19, 1997
    Assignee: Iatron Laboratories, Inc.
    Inventors: Koji Abe, Mitsunao Tanaka, Satoshi Inaba, Masaharu Akimoto
  • Patent number: 5599661
    Abstract: A reagent system and method are described for optically measuring direct bilirubin by the reaction of a bilirubin oxidase, oxidizing agent or diazonium salt, with the direct bilirubin, wherein a tetrapyrrole compound is provided in the presence of the bilirubin oxidase, oxidizing agent or diazonium salt. It is possible to accurately measure the direct bilirubin, which is known to increase considerably in the biological fluids of patients having obstructive jaundice, etc. The reagent system and method are useful in clinical settings, etc.
    Type: Grant
    Filed: December 28, 1994
    Date of Patent: February 4, 1997
    Assignees: Unitika, Ltd., Iatron Laboratories, Inc.
    Inventors: Shoji Senba, Keisuke Kurosaka, Hitoshi Kondo, Masami Kojima, Hiroshi Suzuki
  • Patent number: 5587296
    Abstract: A reagent for assaying glucose, which comprises a first liquid reagent having a pH of 7.5 to 9.5 and containing at least either glucokinase or hexokinase, glucose 6-phosphate dehydrogenase, and adenosine 5'-triphosphate and a second liquid reagent having a pH of 3 to 5 and containing the oxidized form of nicotinamide adenine dinucleotide phosphate. The reagent can be stored as such stably for long in or out of contact with light at normal or low temperatures, so that it can be stored for long in the site of clinical examination and applied to an automatic analyzer without the necessity for dissolution prior to use.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: December 24, 1996
    Assignee: Iatron Laboratories, Inc.
    Inventors: Hiroyuki Tsubota, Reiko Shimada
  • Patent number: 5578598
    Abstract: An antibacterial agent characterized by containing a polyelectrolyte complex prepared by reacting a cationic polymer containing N.sup.+ atoms in repeating units thereof and an anionic polymer containing --COO.sup.--, --SO.sub.3.sup.--, or --PO.sub.3.sup.-- groups in repeating units thereof, and an antibacterial material carrying the above polyelectrolyte complex on a carrier.
    Type: Grant
    Filed: October 3, 1994
    Date of Patent: November 26, 1996
    Assignee: Iatron Laboratories, Inc.
    Inventors: Koji Abe, Mitsunao Tanaka, Satoshi Inaba, Masaharu Akimoto
  • Patent number: 5525476
    Abstract: The present invention relates to a method for determining a lipophilic compound, comprising using an antibody tolerant to one or more organic solvents, and carrying out an antigen-antibody reaction in the presence of one or more organic solvents. By the present method, it is possible to perform an antigen-antibody reaction of the lipophilic compound and the antibody, using an extract of a sample by one or more organic solvents, and thus the procedure becomes simple.Further, the present invention also relates to a monoclonal antibody specific to at least okadaic acid, dinophysistoxin-1 and dinophysistoxin-3, a hybridoma which produces the above monoclonal antibody, and an immunological determination method of diarrheal shellfish poisons using the above monoclonal antibody. According to the present invention, specific determination of all the three types of diarrheal shellfish poisons becomes possible.
    Type: Grant
    Filed: April 27, 1993
    Date of Patent: June 11, 1996
    Assignees: Iatron Laboratories, Inc., Osakafu
    Inventors: Shiro Matsuura, Yutaka Takagaki, Yonekazu Hamano, Ken Fukushi, Keigo Kabasawa, Hiroshi Kita
  • Patent number: 5500345
    Abstract: Monoclonal antibodies specifically reacting with the side face of a C-reactive protein (CRP), i.e., monoclonal antibodies specifically reacting with the side face of a disk-like subunit of a C-reactive protein (CRP), hybridoma producing the monoclonal antibody, and methods for the use thereof are disclosed.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: March 19, 1996
    Assignee: Iatron Laboratories, Inc.
    Inventors: Gilbu Soe, Isao Kohno, Michiyo Tanaka