Abstract: A novel neomorphic form of ibuprofen, processes for preparing the ibuprofen, and method for administering the ibuprofen are provided. The neomorphic form is characterized by having a distinctively less bitter taste and causes less burning sensation upon swallowing. The neomorphic form of ibuprofen contains an amorphous ibuprofen. Tests indicate that the neomorphic form is less irritating to the gastrointestinal tract of animals upon administration.
Abstract: There is provided a water-in-oil (w/o) microemulsion which readily converts to an oil-in-water (o/w) emulsion by the addition of aqueous fluid to the w/o microemulsion, whereby any water-soluble biologically-active material in the aqueous phase is released for absorption by the body. The w/o microemulsion is particularly useful for storing proteins and the like for long periods of time at room temperature and above until they are ready for use, at which time the addition of aqueous fluid converts the microemulsion to an o/w emulsion and releases the protein.
Type:
Grant
Filed:
May 20, 1992
Date of Patent:
August 22, 1995
Assignee:
Ibah, Inc.
Inventors:
Albert J. Owen, Seang H. Yiv, Ani B. Sarkahian