Patents Assigned to IBBEX, Inc.
  • Chromogenic substrates of sialidase and methods of making and using the same
    Patent number: 6844346
    Abstract: The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. These compounds are based upon N-acetylneuraminic acid glycosides. In particular, this invention provides a novel class of these compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
    Type: Grant
    Filed: December 24, 2002
    Date of Patent: January 18, 2005
    Assignees: IBBEX, Inc., Univ. of Alabama at Birmingham
    Inventors: Stephen C. Johnson, Ashraf Saeed, Ming Luo
  • Chromogenic substrates of sialidase and methods of making and using the same
    Patent number: 6812332
    Abstract: The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: November 2, 2004
    Assignees: IBBEX, Inc., UAB Research Foundation
    Inventors: Stephen C. Johnson, Ashraf Saeed, Ming Luo
  • Chromogenic substrates of sialidase of bacterial, viral, protozoa, and vertebrate origin and methods of making and using the same
    Patent number: 6667161
    Abstract: The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
    Type: Grant
    Filed: October 5, 1999
    Date of Patent: December 23, 2003
    Assignees: Ibbex, Inc., UAB Research Foundation
    Inventors: Stephen C. Johnson, Ming Lou, Shijia Yan
  • Chromogenic substrates of sialidase and methods of making and using the same
    Patent number: 6512100
    Abstract: The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
    Type: Grant
    Filed: August 30, 2000
    Date of Patent: January 28, 2003
    Assignees: Ibbex, Inc., UAB Research Foundation
    Inventors: Stephen C Johnson, Ashraf Saeed, Ming Luo