Abstract: The present invention relates generally to an improved method and apparatus for measurement of properties of a sample as a function of temperature. The method and apparatus are based on formation of a stable temperature gradient through the holding fixture such as a cell or a plate containing the sample under study, measurement of the property of interest as a function of position, and relating the positions of the measurements to the temperature of the studied sample at that position. In the preferred application, thermal and thermodynamic properties of solutes are obtained. Provisions are described to combine optical interrogation with Raman spectroscopy. Alternate technique of interrogation is total internal fluorescence reflection. Chemical reaction rates as function of temperature can be advantageously studied including reactions catalyzed by enzymes.
Type:
Grant
Filed:
July 10, 2006
Date of Patent:
December 11, 2007
Assignee:
IBET, Inc.
Inventors:
Armen P. Sarvazyan, George Eric Plum, Sergey Tsyuryupa
Abstract: The present invention relates generally to a method and apparatus for measurement of optical properties of a liquid as a function of temperature. The method and apparatus are based on formation of a stable temperature gradient through the holding cell containing the liquid under study, measurement of the optical property or properties of interest as a function of position, and relating the positions of the optical measurements to the temperature of the studied liquid at that position. In the preferred application, thermal and thermodynamic properties of solutes are obtained.