Abstract: A heparinase derived from Flavobacterium heparinum which meets all requirements for a clinical reagent that can eliminate heparin interference of normal blood function has been developed. The heparinase, derived from Flavobacterium heparinum, is free of a component that inhibits coagulation wherein the anticoagulant component does not bind, and the heparinase does bind, to a polysulfated resin having a pH of 7.0 and a conductivity between 3 and 12 mmhos. It is stable under normal manufacturing, shipping and clinical storage conditions for at least one year. The heparinase in useful in vitro to eliminate the interference in hematological assays due to the presence of heparin. The heparinase is also useful for the in vivo neutralization of heparin during surgical procedures. Advantages of this enzyme are that it achieves neutralization faster and more completely than previously available enzymes and is stable for long periods of time.

Abstract: A heparinase formulation derived from Flavobacterium heparinum which meets all requirements for a clinical reagent that can eliminate heparin interference of normal blood function has been developed. The heparinase, derived from Flavobacterium heparinum, is free of a component that inhibits coagulation. It is stable under normal manufacturing, shipping and clinical storage conditions for at least one year. The heparinase in useful in vitro to eliminate the interference in hematological assays due to the presence of heparin. The heparinase is also useful for the in vivo neutralization of heparin during surgical procedures. Advantages of this preparation are that it achieves neutralization faster and more completely than previously available compositions and is stable for long periods of time.

Abstract: There is provided a rotary valve system for an internal combustion engine which has the capabilities of advancing of retarding the openings of the valves. The rotary valves comprise a cylindrical valve body rotatably disposed within a valve sleeve. The valve sleeve is rotatably disposed within the head of the internal combustion engine. Both intake and exhaust functions have a rotary valve. Under normal operation, the valve sleeve and body rotate at the same speed opening intake or exhaust ports at the appropriate times. Advancing or retarding of the valve timing is accomplished by varying the rotational velocity of either the valve body or the valve sleeve which in turn rotates the valve sleeve relative to the valve body to either advance or retard the opening of the appropriate port. A second embodiment has a valve sleeve which is normally stationary but is also selectively rotatable to effect the valve timing.