Patents Assigned to iBio, Inc.
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Patent number: 11673926Abstract: Materials and methods for in vivo de-glycosylation of recombinant N-glycosylated proteins by co-expression with bacterial PNGase F (Peptide: N-glycosidase F) in plants, using a transient expression system are described. Methods are described which, for example, produce recombinant proteins of interest in plants in a non-glycosylated form. A method of expressing active bacterial PNGase F in plants also is provided.Type: GrantFiled: June 7, 2012Date of Patent: June 13, 2023Assignee: IBIO, INC.Inventors: Tarlan Mammedov, Vidadi Yusibov
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Patent number: 11545238Abstract: Provided herein are methods for design of engineered polypeptides that recapitulate molecular structure features of a predetermined portion of a reference protein structure, e.g., an antibody epitope or a protein binding site. A Machine Learning (ML) model is trained by labeling blueprint records generated from a reference target structure with scores calculated based on computational protein modeling of polypeptide structures generated by the blueprint records. The method may include training an ML model based on a first set of blueprint records, or representations thereof, and a first set of scores, each blueprint record from the first set of blueprint records associated with each score from the first set of scores. After the training, the machine learning model may be executed to generate a second set of blueprint records. A set of engineered polypeptides are then generated based on the second set of blueprint records.Type: GrantFiled: December 1, 2020Date of Patent: January 3, 2023Assignee: IBIO, INC.Inventors: Matthew P. Greving, Alexander T. Taguchi, Kevin E. Hauser
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Patent number: 10844392Abstract: This document provides materials and methods for producing endostatin fusion polypeptides having anti-fibrotic activity. For example, provided herein are fusion polypeptides having an IgG Fc domain and a portion of human endostatin that can form high molecular weight multimers, as well as methods for producing such fusion polypeptides in plant cells.Type: GrantFiled: June 3, 2016Date of Patent: November 24, 2020Assignees: iBio, Inc., MUSC FOUNDATION FOR RESEARCH DEVELOPMENT, NOVICI BIOTECH LLCInventors: Carol Feghali-Bostwick, Terence E Ryan, Hal S. Padgett, Matthew McGee
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Patent number: 9809644Abstract: Antibodies against influenza hemagglutinin, compositions containing the antibodies, and methods of using the antibodies are provided herein.Type: GrantFiled: July 21, 2014Date of Patent: November 7, 2017Assignee: iBio Inc.Inventors: Vidadi Yusibov, Vadim Mett, Jessica Chichester, Lauren Goldschmidt
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Patent number: 9765349Abstract: The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g., replication, cell-to-cell movement, or long distance movement. The carrier vector supplies the missing function in trans. Certain producer vectors lack a functional coat protein coding sequence, in which case the corresponding producer vector supplies coat protein in trans. The invention also provides novel plant viral vectors and methods of use, e.g., to produce polypeptides or active RNAs in plants.Type: GrantFiled: January 4, 2017Date of Patent: September 19, 2017Assignee: iBio, Inc.Inventors: Oleg Fedorkin, Shailaja Rabindran, Vidadi Yusibov
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Patent number: 9551001Abstract: The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g., replication, cell-to-cell movement, or long distance movement. The carrier vector supplies the missing function in trans. Certain producer vectors lack a functional coat protein coding sequence, in which case the corresponding producer vector supplies coat protein in trans. The invention also provides novel plant viral vectors and methods of use, e.g., to produce polypeptides or active RNAs in plants.Type: GrantFiled: January 22, 2015Date of Patent: January 24, 2017Assignee: iBio, Inc.Inventors: Oleg Fedorkin, Shailaja Rabindran, Vidadi Yusibov
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Patent number: 9115201Abstract: Antibodies against influenza neuraminidase, compositions containing the antibodies, and methods of using the antibodies are provided herein.Type: GrantFiled: April 16, 2014Date of Patent: August 25, 2015Assignee: iBio Inc.Inventors: Vidadi Yusibov, Vadim Mett, Yoko Shoji
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Patent number: 9012199Abstract: Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B (Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest.Type: GrantFiled: October 23, 2013Date of Patent: April 21, 2015Assignee: iBio, Inc.Inventors: Vidadi Yusibov, Vadim Mett, Konstantin Musiychuk
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Patent number: 8962278Abstract: Provided are oligonucleotides for isolating human antibody cDNAs from cells or cell lines, such as hybridomas. The invention also provides cDNAs that encode at least one provided CDR of a heavy chain or a light chain of a human monoclonal antibody that binds to B. anthracis protective antigen; and cDNAs that encode at least one provided CDR of a heavy chain or a light chain of a human monoclonal antibody that binds to B. anthracis lethal factor. The invention further provides expression vectors that contain one or more cDNAs isolated according to the methods of the invention, host cells expressing one or more inventive cDNAs, and transgenic plants and animals that express one or more inventive cDNAs. In certain embodiments of the invention the expression system is a plant-based expression system. The invention further provides antibody compositions comprising one or more antibodies produced by expressing a cDNA isolated according to the methods of the invention in a suitable expression system.Type: GrantFiled: August 3, 2006Date of Patent: February 24, 2015Assignee: iBio Inc.Inventors: Vidadi Yusibov, Vadim Mett, Anna Hull
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Patent number: 8951791Abstract: The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g., replication, cell-to-cell movement, or long distance movement. The carrier vector supplies the missing function in trans. Certain producer vectors lack a functional coat protein coding sequence, in which case the corresponding producer vector supplies coat protein in trans. The invention also provides novel plant viral vectors and methods of use, e.g., to produce polypeptides or active RNAs in plants.Type: GrantFiled: December 2, 2013Date of Patent: February 10, 2015Assignee: iBio, Inc.Inventors: Oleg Fedorkin, Shailaja Rabindran, Vidadi Yusibov
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Patent number: 8945580Abstract: The present invention provides antigens and vaccines useful in prevention of infection by Yersinia pestis. The present invention provides pharmaceutical compositions of such antigens and/or vaccines. The present invention provides methods for the production of Y. pestis protein antigens in plants, as well as methods for their use in the treatment and/or prevention of Y. pestis infection.Type: GrantFiled: February 25, 2013Date of Patent: February 3, 2015Assignee: iBio Inc.Inventors: Vidadi Yusibov, Vadim Mett, Konstantin Musiychuk
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Publication number: 20140314754Abstract: Antibodies against influenza neuraminidase, compositions containing the antibodies, and methods of using the antibodies are provided herein.Type: ApplicationFiled: April 16, 2014Publication date: October 23, 2014Applicant: iBio Inc.Inventors: Vidadi Yusibov, Vadim Mett, Yoko Shoji
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Publication number: 20140220674Abstract: The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g., replication, cell-to-cell movement, or long distance movement. The carrier vector supplies the missing function in trans. Certain producer vectors lack a functional coat protein coding sequence, in which case the corresponding producer vector supplies coat protein in trans. The invention also provides novel plant viral vectors and methods of use, e.g., to produce polypeptides or active RNAs in plants.Type: ApplicationFiled: December 2, 2013Publication date: August 7, 2014Applicant: iBio, Inc.Inventors: Oleg Fedorkin, Shailaja Rabindran, Vidadi Yusibov
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Patent number: 8784819Abstract: Antibodies against influenza hemagglutinin, compositions containing the antibodies, and methods of using the antibodies are provided herein.Type: GrantFiled: September 29, 2010Date of Patent: July 22, 2014Assignee: iBio Inc.Inventors: Vidadi Yusibov, Vadim Mett, Jessica Chichester, Lauren Goldschmidt
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Patent number: 8778348Abstract: The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by Trypanosoma protozoa. Provided are recombinant protein antigens, compositions, and methods for the production and use of such antigens and vaccine compositions.Type: GrantFiled: April 28, 2008Date of Patent: July 15, 2014Assignee: iBio Inc.Inventors: Elisabeth Knapp, Vidadi Yusibov
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Publication number: 20140186886Abstract: Materials and methods for in vivo de-glycosylation of recombinant N-glycosylated proteins by co-expression with bacterial PNGase F (Peptide: N-glycosidase F) in plants, using a transient expression system are described. Methods are described which, for example, produce recombinant proteins of interest in plants in a non-glycosylated form. A method of expressing active bacterial PNGase F in plants also is provided.Type: ApplicationFiled: June 7, 2012Publication date: July 3, 2014Applicant: IBIO, INC.Inventors: Tarlan Mammedov, Vidadi Yusibov
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Patent number: 8734803Abstract: Antibodies against influenza neuraminidase, compositions containing the antibodies, and methods of using the antibodies are provided herein.Type: GrantFiled: September 28, 2009Date of Patent: May 27, 2014Assignee: iBio Inc.Inventors: Vidadi Yusibov, Vadim Mett, Yoko Shoji
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Publication number: 20140141508Abstract: Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B (Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest.Type: ApplicationFiled: October 23, 2013Publication date: May 22, 2014Applicant: iBio, Inc.Inventors: Vidadi Yusibov, Vadim Mett, Konstantin Musiychuk
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Patent number: 8597942Abstract: The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g., replication, cell-to-cell movement, or long distance movement. The carrier vector supplies the missing function in trans. Certain producer vectors lack a functional coat protein coding sequence, in which case the corresponding producer vector supplies coat protein in trans. The invention also provides novel plant viral vectors and methods of use, e.g., to produce polypeptides or active RNAs in plants.Type: GrantFiled: September 23, 2011Date of Patent: December 3, 2013Assignee: iBio, Inc.Inventors: Oleg Fedorkin, Shailaja Rabindran, Vidadi Yusibov
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Patent number: 8591909Abstract: Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B (Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest.Type: GrantFiled: April 12, 2012Date of Patent: November 26, 2013Assignee: iBio, Inc.Inventors: Vidadi Yusibov, Vadim Mett, Konstantin Musiychuk