Patents Assigned to Ibis Bioscience, Inc.
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Patent number: 8987660Abstract: The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly— or multiply-charged ions by selective ion filtering carried out by a digital thresholding process.Type: GrantFiled: May 7, 2012Date of Patent: March 24, 2015Assignee: Ibis Biosciences, Inc.Inventors: Steven A. Hofstadler, Jared J. Drader, Amy L. Schink
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Publication number: 20150045239Abstract: Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.Type: ApplicationFiled: December 10, 2013Publication date: February 12, 2015Applicant: Ibis Biosciences, Inc.Inventors: Jared J. Drader, Gordon Bruce Collier, Steven A. Hofstadler
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Patent number: 8921047Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.Type: GrantFiled: October 29, 2012Date of Patent: December 30, 2014Assignee: Ibis Biosciences, Inc.Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
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Patent number: 8822156Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.Type: GrantFiled: September 23, 2011Date of Patent: September 2, 2014Assignee: Ibis Biosciences, Inc.Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Raymond Ranken, Thomas A. Hall
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Patent number: 8815513Abstract: The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.Type: GrantFiled: October 31, 2007Date of Patent: August 26, 2014Assignee: Ibis Biosciences, Inc.Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, James C. Hannis
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Patent number: 8802372Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.Type: GrantFiled: October 30, 2007Date of Patent: August 12, 2014Assignee: Ibis Biosciences, Inc.Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence Blyn, Thomas A. Hall, Yun Jiang, James C. Hannis, Neill White, Vivek Samant, Mark W. Eshoo, Jared James Drader
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Patent number: 8796617Abstract: The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.Type: GrantFiled: January 3, 2012Date of Patent: August 5, 2014Assignee: Ibis BioSciences, Inc.Inventors: Steven A. Hofstadler, Jose R. Gutierrez, James C. Hannis, Jared J. Drader, Rex O. Bare, Jeffrey C. Smith, Paul J. Gleason, Jared Nathanson
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Patent number: 8614087Abstract: Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.Type: GrantFiled: May 2, 2012Date of Patent: December 24, 2013Assignee: Ibis Biosciences, Inc.Inventors: Jared J. Drader, Gordon Bruce Collier, Steven A. Hofstadler
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Patent number: 8609430Abstract: Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.Type: GrantFiled: August 27, 2012Date of Patent: December 17, 2013Assignee: Ibis Biosciences, Inc.Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith
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Patent number: 8563250Abstract: The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.Type: GrantFiled: March 5, 2007Date of Patent: October 22, 2013Assignee: Ibis Biosciences, Inc.Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil, Stanley T. Crooke, James C. Hannis
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Patent number: 8551738Abstract: There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products.Type: GrantFiled: November 11, 2009Date of Patent: October 8, 2013Assignee: Ibis Biosciences, Inc.Inventors: David J. Ecker, Steven A. Hofstadler, Thomas A. Hall, Kristin Sannes-Lowery
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Patent number: 8550694Abstract: Cartridges useful for mixing materials, such as fluidic materials are provided. A cartridge typically includes a body structure having surfaces that define a cavity with upper and lower portions. A rotatable member generally extends along a horizontal axis in the upper portion of the cavity. One or more protrusions typically extend outward from the rotatable member and into the lower portion of the cavity, and are configured to mix the material when the material is disposed in the cavity. Related mixing stations, systems, kits, and methods are also provided.Type: GrantFiled: September 16, 2009Date of Patent: October 8, 2013Assignee: Ibis Biosciences, Inc.Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith
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Patent number: 8546082Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of sepsis-causing bacteria by molecular mass and base composition analysis.Type: GrantFiled: May 25, 2007Date of Patent: October 1, 2013Assignee: Ibis Biosciences, Inc.Inventors: Thomas A. Hall, Rangarajan Sampath, Vanessa Harpin, Steven A. Hofstadler, Yun Jiang
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Patent number: 8534447Abstract: Systems, computer program products, and methods useful for handling or managing microplates are provided.Type: GrantFiled: September 16, 2009Date of Patent: September 17, 2013Assignee: Ibis Biosciences, Inc.Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith, Kevin S. Oberkramer, Ronald K. Bergold
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Patent number: 8476415Abstract: The present invention provides a method for rapid solution capture purification of nucleic acids for subsequent analysis by electrospray mass spectrometry which is efficient and cost-effective relative to existing methods. The present invention also provides kits useful for practicing rapid solution capture of nucleic acids so that purified samples are in condition for analysis by electrospray mass spectrometry.Type: GrantFiled: April 16, 2012Date of Patent: July 2, 2013Assignee: Ibis Biosciences, Inc.Inventors: Steven A. Hofstadler, Lendell L. Cummins
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Patent number: 8470261Abstract: The present invention provides integrated sample preparation systems and stabilized enzyme mixtures. In particular, the present invention provides microfluidic cards configured for processing a sample and generating DNA libraries that are suitable for use in sequencing methods or other suitable nucleic acid analysis methods. The present invention also provides stabilized enzyme mixtures containing an enzyme, BSA, and a sugar. Such enzyme mixtures may be lyophilized and stored at room temperature without significant loss of enzyme activity for months.Type: GrantFiled: May 6, 2011Date of Patent: June 25, 2013Assignee: Ibis Biosciences, Inc.Inventors: Mark W. Eshoo, John Picuri
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Patent number: 8407010Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.Type: GrantFiled: March 17, 2008Date of Patent: March 26, 2013Assignee: Ibis Biosciences, Inc.Inventors: Steven A. Hofstadler, Thomas A. Hall, David J. Ecker, Lawrence B. Blyn, Mark W. Eshoo, Vivek Samant, Neill White
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Patent number: 8394945Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.Type: GrantFiled: March 7, 2007Date of Patent: March 12, 2013Assignee: Ibis Biosciences, Inc.Inventors: Rangarajan Sampath, Thomas A. Hall, David J. Ecker, Lawrence Blyn
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Patent number: 8380442Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.Type: GrantFiled: October 31, 2007Date of Patent: February 19, 2013Assignee: Ibis Bioscience, Inc.Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
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Patent number: 8298760Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.Type: GrantFiled: February 13, 2007Date of Patent: October 30, 2012Assignee: Ibis Bioscience, Inc.Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke