Abstract: Methods for ischemic conditioning treatments of a chronic medical condition are provided. Baseline disease-related parameters of a patient with a chronic medical condition are measured. Ischemia is induced in the patient by occluding and releasing arterial flow in one or more extremities of the patient. Post-ischemia parameters in the patient are measured. The baseline and post-ischemia parameters are compared to provide an assessment of an ischemic conditioning treatment of a chronic medical condition. The repeated, scheduled delivery of ischemic conditioning provides a beneficial, therapeutic effect on the chronic medical condition. Also provided is a device for pulse oximetry during periods of absent or low pulsatile blood flow including an artificial pulse generator as well as the use of said device in assessment of ischemic conditioning.
Type:
Grant
Filed:
November 25, 2008
Date of Patent:
March 24, 2015
Assignee:
IC Therapeutics
Inventors:
Morteza Naghavi, Albert Andrew Yen, Haider Hassan, David Panthagani
Abstract: A system and method for inducing physiological effects of ischemic conditioning and physiological effects of shear stress in a subject's body that mimic the effect of exercise on the subject. The disclosure includes a first device configured to cause ischemia, a second device configured to mechanically generate arterial shear stress, and a third device configured to monitor one or more of markers of ischemia or hemodynamic parameters and further including a microcontroller and actuators to cause the ischemia for a preset duration and then stop the ischemia for a preset duration, and to repeat the ischemia and reflow periods according to a preset program, simultaneously cause the second device to mechanically generate arterial shear stress according to a preset program of mechanical pulse amplitude, duration, and frequency; and to concurrently monitor hemodynamic parameters or markers of ischemia.
Type:
Grant
Filed:
December 12, 2013
Date of Patent:
February 17, 2015
Assignee:
IC Therapeutics Inc.
Inventors:
Morteza Naghavi, Albert Yen, Timothy O'Brien, Stephan Cleboski, Timothy Brinkley, David Panthagani
Abstract: Methods and apparatus for ischemic conditioning treatment in a patient are provided. Transient ischemia is caused by interrupting blood flow to a tissue. Markers of ischemia and metabolism are monitored in the tissue and the induced ischemia is adjusted based on the monitoring results.
Type:
Application
Filed:
May 23, 2008
Publication date:
July 22, 2010
Applicant:
IC THERAPEUTICS, INC.
Inventors:
Morteza Naghavi, Albert Andrew Yen, Haider Hassan, David Panthagani
Abstract: A method for ischemic conditioning treatment in a patient is provided. Transient ischemia is caused by interrupting blood flow to a tissue and a response to the ischemic conditioning treatments is monitored and the ischemia and response thereto is adjusted and controlled based on the monitoring results.
Type:
Application
Filed:
November 23, 2009
Publication date:
April 29, 2010
Applicant:
IC THERAPEUTICS, INC.
Inventors:
Morteza Naghavi, Albert Andrew Yen, Haider Hassan, David Panthagani
Abstract: Methods for ischemic conditioning treatments of a chronic medical condition are provided. Baseline disease-related parameters of a patient with a chronic medical condition are measured. Ischemia is induced in the patient by occluding and releasing arterial flow in one or more extremities of the patient. Post-ischemia parameters in the patient are measured. The baseline and post-ischemia parameters are compared to provide an assessment of an ischemic conditioning treatment of a chronic medical condition. The repeated, scheduled delivery of ischemic conditioning provides a beneficial, therapeutic effect on the chronic medical condition. Also provided is a device for pulse oximetry during periods of absent or low pulsatile blood flow including an artificial pulse generator as well as the use of said device in assessment of ischemic conditioning.
Type:
Application
Filed:
July 29, 2009
Publication date:
November 19, 2009
Applicant:
IC THERAPEUTICS
Inventors:
Morteza Naghavi, Albert Andrew Yen, Haider Hassan, David Panthagani
Abstract: Methods for ischemic conditioning treatments of a chronic medical condition are provided. Baseline disease-related parameters of a patient with a chronic medical condition are measured. Ischemia is induced in the patient by occluding and releasing arterial flow in one or more extremities of the patient. Post-ischemia parameters in the patient are measured. The baseline and post-ischemia parameters are compared to provide an assessment of an ischemic conditioning treatment of a chronic medical condition. The repeated, scheduled delivery of ischemic conditioning provides a beneficial, therapeutic effect on the chronic medical condition. Also provided is a device for pulse oximetry during periods of absent or low pulsatile blood flow including an artificial pulse generator as well as the use of said device in assessment of ischemic conditioning.
Type:
Application
Filed:
November 25, 2008
Publication date:
May 28, 2009
Applicant:
IC THERAPEUTICS
Inventors:
Morteza Naghavi, Albert Andrew Yen, Haider Hassan, David Panthagani