Patents Assigned to Icagen, Incorporated
  • Human HAC3
    Publication number: 20070128653
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.
    Type: Application
    Filed: January 19, 2007
    Publication date: June 7, 2007
    Applicant: ICAGEN, INCORPORATED
    Inventor: Timothy Jegla
  • Human HAC3
    Patent number: 7169893
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: January 30, 2007
    Assignee: Icagen, Incorporated
    Inventor: Timothy J. Jegla
  • Human HAC3
    Patent number: 7153668
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: December 26, 2006
    Assignee: Icagen, Incorporated
    Inventor: Timothy J. Jegla
  • Small and intermediate conductance, calcium-activated potassium channels and uses thereof
    Patent number: 7026451
    Abstract: This invention relates to small and intermediate conductance, calcium-activated potassium channel proteins. More specifically the invention relates to compositions and methods for making and detecting calcium-activated potassium channel proteins and the nucleic acids encoding calcium-activated potassium channel proteins. The invention also provides methods and compositons for assaying compounds which increase or decrease potassium ion flux through a calcium-activated potassium channel.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: April 11, 2006
    Assignees: Icagen, Incorporated, Oregon Health Sciences University
    Inventors: John P. Adelman, James Maylie, Chris T. Bond, Christopher P. Silvia
  • Human Elk, a voltage-gated potassium channel subunit
    Publication number: 20050227250
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
    Type: Application
    Filed: October 15, 2004
    Publication date: October 13, 2005
    Applicant: ICAGEN INCORPORATED
    Inventors: Timothy Jegla, Alan Wickenden
  • Small and intermediate conductance, calcium-activated potassium channels and uses thereof
    Publication number: 20050214845
    Abstract: This invention relates to small and intermediate conductance, calcium-activated potassium channel proteins. More specifically, the invention relates to compositions and methods for making and detecting calcium-activated potassium channel proteins and the nucleic acids encoding calcium-activated potassium channel proteins. The invention also provides methods and compositions for assaying compounds which increase or decrease potassium ion flux through a calcium-activated potassium channel.
    Type: Application
    Filed: April 27, 2005
    Publication date: September 29, 2005
    Applicants: Oregon Health Sciences University, Icagen, Incorporated
    Inventors: John Adelman, James Maylie, Chris Bond, Christopher Silvia
  • pH sensitive potassium channel in spermatocytes
    Patent number: 6897291
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Slo3, a pH sensitive potassium channel expressed in sperm; antibodies to Slo3; methods of screening for Slo3 inhibitors; and methods of screening for Slo3 homologs.
    Type: Grant
    Filed: March 6, 2000
    Date of Patent: May 24, 2005
    Assignees: Icagen, Incorporated, The Washington University
    Inventors: Lawrence Salkoff, Matthew Schreiber, Chris Silvia
  • Human Elk, a voltage-gated potassium channel subunit
    Patent number: 6833440
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
    Type: Grant
    Filed: May 28, 2002
    Date of Patent: December 21, 2004
    Assignee: Icagen, Incorporated
    Inventors: Timothy J. Jegla, Alan Wickenden
  • PH sensitive potassium channel in spermatocytes
    Patent number: 6815539
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Slo3, a pH sensitive potassium channel expressed in sperm; antibodies to Slo3; methods of screening for Slo3 inhibitors; and methods of screening for Slo3 homologs.
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: November 9, 2004
    Assignees: Icagen, Incorporated, The Washington University
    Inventors: Lawrence Salkoff, Matthew Schreiber, Chris Silvia
  • Small and intermediate conductance, calcium-activated potassium channels and uses thereof
    Patent number: 6797486
    Abstract: This invention relates to small and intermediate conductance, calcium-activated potassium channel proteins. More specifically, the invention relates to compositions and methods for making and detecting calcium-activated potassium channel proteins and the nucleic acids encoding calcium-activated potassium channel proteins. The invention also provides methods and compositions for assaying compounds which increase or decrease potassium ion flux through a calcium-activated potassium channel.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: September 28, 2004
    Assignees: ICAgen, Incorporated, Oregon Health Sciences University
    Inventors: John P. Adelman, James Maylie, Chris T. Bond, Christopher P. Silvia
  • Kv6.2, a voltage-gated potassium channel subunit
    Publication number: 20040126849
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Kv6.2, antibodies to Kv6.2, methods of detecting Kv6.2, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active Kv6.2, and kits for screening for activators and inhibitors of voltage gated potassium channels comprising Kv6.2.
    Type: Application
    Filed: December 16, 2003
    Publication date: July 1, 2004
    Applicant: ICAgen, Incorporated
    Inventor: Timothy J. Jegla
  • Human Eag2
    Patent number: 6753412
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Eag2, antibodies to Eag2, methods of detecting Eag2, and methods of screening for modulators of Eag2 potassium channels using biologically active Eag2. The invention further provides, in a computer system, a method of screening for mutations of human Eag2 genes as well as a method for identifying a three-dimensional structure of Eag2 polypeptide monomers.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: June 22, 2004
    Assignee: Icagen, Incorporated
    Inventors: Timothy J. Jegla, Yi Liu
  • DNA encoding small and intermediate conductance calcium-activated potassium channels
    Patent number: 6692937
    Abstract: This invention relates to small and intermediate conductance, calcium-activated potassium channel proteins. More specifically, the invention relates to compositions and methods for making and detecting calcium-activated potassium channel proteins and the nucleic acids encoding calcium-activated potassium channel proteins. The invention also provides methods and compositions for assaying compounds which increase or decrease potassium ion flux through a calcium-activated potassium channel.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: February 17, 2004
    Assignees: ICAgen, Incorporated, Oregon Health Sciences University
    Inventors: John P. Adelman, James Maylie, Chris T. Bond, Christopher P. Silvia
  • Kv6.2, a voltage-gated potassium channel subunit
    Patent number: 6680180
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Kv6.2, antibodies to Kv6.2, methods of detecting Kv6.2, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active Kv6.2, and kits for screening for activators and inhibitors of voltage gated potassium channels comprising Kv6.2.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: January 20, 2004
    Assignee: Icagen, Incorporated
    Inventor: Timothy J. Jegla
  • Human Eag2
    Publication number: 20030211529
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Eag2, antibodies to Eag2, methods of detecting Eag2, and methods of screening for modulators of Eag2 potassium channels using biologically active Eag2. The invention further provides, in a computer system, a method of screening for mutations of human Eag2 genes as well as a method for identifying a three-dimensional structure of Eag2 polypeptide monomers.
    Type: Application
    Filed: April 22, 2003
    Publication date: November 13, 2003
    Applicant: ICAgen, Incorporated
    Inventors: Timothy J. Jegla, Yi Liu
  • Human Eag2
    Patent number: 6586179
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Eag2, antibodies to Eag2, methods of detecting Eag2, and methods of screening for modulators of Eag2 potassium channels using biologically active Eag2. The invention further provides, in a computer system, a method of screening for mutations of human Eag2 genes as well as a method for identifying a three-dimensional structure of Eag2 polypeptide monomers.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: July 1, 2003
    Assignee: ICAgen, Incorporated
    Inventors: Timothy J. Jegla, Yi Liu
  • Human Elk, a voltage-gated potassium channel subunit
    Publication number: 20030077731
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
    Type: Application
    Filed: May 28, 2002
    Publication date: April 24, 2003
    Applicant: ICAgen, Incorporated
    Inventors: Timothy J. Jegla, Alan Wickenden
  • Human elk a voltage-gated potassium channel subunit
    Patent number: 6413741
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: July 2, 2002
    Assignee: ICAgen, Incorporated
    Inventors: Timothy J. Jegla, Alan Wickenden