Abstract: A single protein which is the substance of the PGE2 synthesis activity in brain soluble fractions of LPS administered rats has been purified and identified. The protein has an activity of synthesizing PGE2 from PGH2, and further, has an activity of synthesizing PGE2 from arachidonic acid in combination with COX.
Type:
Application
Filed:
January 3, 2007
Publication date:
May 31, 2007
Applicants:
Chugai Seiyaku Kabushiki Kaisha, a Japanese corporation, Ichiro Kudo