Abstract: 1-Trifluoromethylphenyl-2-(substituted phenyl)iminopyrrolidines of the formula ##STR1## in which R is H, halogen, or C.sub.1 -C.sub.4 alkyl; R' is CF.sub.3, CH.sub.3, CF.sub.2 CHF.sub.2, OCF.sub.2 CHF.sub.2, OCHF.sub.2, OCF.sub.3, SCH.sub.3, S(O)CH.sub.3, SO.sub.2 CH.sub.3, methoxyiminomethyl, methoxyimino-1-ethyl, benzoyloxyiminomethyl, and benzoyloxyimino-1-ethyl; and X and Y are independently H, halogen, CN or CF.sub.3, are useful as herbicidal agents.
Abstract: A polyisocyanate composition, suitable for use in the production of elastomers by the RIM process, or foams, said composition being the product of reacting an imino-functional or enamine-containing compound having a molecular weight of at least 1000 with a stoichiometric excess of an organic polyisocyanate.
Type:
Grant
Filed:
September 16, 1988
Date of Patent:
March 6, 1990
Assignee:
ICI Americas Inc/Imperial Chemical Industries PLC
Inventors:
Edward F. Cassidy, Herbert R. Gillis, Malcolm Hannaby, Jan W. Leenslag, Alain Parfondry
Abstract: The present invention comprises certain amide derivatives of 4,8-disubstituted quinoline-3-carboxylic acids of formula I; pharmaceutically acceptable salts of the compounds of formula I; pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable salt thereof, for use in the treatment of anxiety; and processes for the manufacture of the compounds of formula I, as well as intermediates for use in such manufacture.
Abstract: An iminooxazolidine having the formula ##STR1## wherein X and Y are the same or different and are selected from the group consisting of cyano, halogen, acyl, alkyl, alkylthio, haloalkyl, trihalomethylthio, alkylsulfenyl, alkoxy, carboalkoxy and trihalomethyl wherein the alkyl groups have from 1 to 5 carbon atoms;m is 1 or 2;n is 0, 1 or 2; andR is hydrogen or a lower alkyl group having from 1 to 3 carbon atoms, preferably an ethyl group, and herbicidally effective salts thereof.
Abstract: Novel insecticides have the formula ##STR1## in which R.sub.1 is hydrogen, fluoro or trifluoromethyl;R.sub.2 is(a) halogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl, C.sub.1 -C.sub.2 alkoxy or C.sub.1 -C.sub.2 haloalkoxy if R.sub.1 is hydrogen or fluoro; or(b) hydrogen if R.sub.1 is trifluoromethyl;R.sub.3 is hydrogen or halogen; andR.sub.4 is hydrogen or mono- or poly-halogen.
Abstract: Novel trisubstituted benzoic acid intermediates which are useful in the preparation of certain herbicidal 2-(2,3,4-trisubstituted benzoyl)-1,3-cyclohexanediones. The intermediate benzoic acids of this invention have the following structural formula ##STR1## wherein R.sup.6 is chlorine, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio or hydroxy; n is the integer 0 or 2; and R.sup.7 is C.sub.1 -C.sub.4 alkyl.
Abstract: This invention provides a series of novel heterocyclic carboxamides of formula I in which the group --Y--Z< is selected from --C(Ra).dbd.C<, --N.dbd.C<, and --CH(Ra)--CH< and the other radicals have the meanings defined in the following specification.The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseasxes, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
Abstract: The invention concerns a novel therapeutic agent for use in reducing raised serum uric acid levels comprising 3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid or a pharmaceutically acceptable salt thereof.
Abstract: Novel fungicidal pyridyl cyclopropane carboxamides having the general structural formula ##STR1## in which R is selected from the group halogen C.sub.1 -C.sub.3 alkoxy and C.sub.1 -C.sub.3 haloalkoxy, R.sub.1 is selected from the group of --H and --C.tbd.N; and R.sub.2 is selected from the group of --H, 1--CH.sub.3 and 2--CH.sub.3 ; X is O or S; and fungicidally acceptable organic and inorganic salts thereof. These compounds provide excellent control of fungal growth.
Abstract: This invention provides a series of novel heterocyclic aliphatic carboxamides of formula I in which the group >Z--Y--X< is selected from >C.dbd.CH--N<, >N--CH.dbd.C<, >C.dbd.N--N< and >N--N.dbd.C< and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
Abstract: Novel fungicidal pyridyl imidates having the general structural formula ##STR1## wherein R is selected from the group consisting of C.sub.1 -C.sub.16 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8 substituted alkenyl, C.sub.3 -C.sub.4 carboalkoxyalkyl, aryl, arylalkyl having C.sub.1 -C.sub.3 alkyl, substituted aryl and arylalkyl wherein the substituents are --Cl, --Br, --F and --NO.sub.2, furfuryl pyridyl, C.sub.1 -C.sub.6 alkyl substituted phosphorus, and ##STR2## wherein R.sub.3 and R.sub.4 are C.sub.1 -C.sub.10 alkyl and can form a heterocyclic ring, R.sub.1 is selected from the group consisting of halogen, C.sub.1 -C.sub.3 alkoxy and C.sub.1 -C.sub.3 haloalkoxy, R.sub.2 is selected from the group consisting of methyl and hydrogen, and X is S or O; and fungicidally acceptable organic and inorganic salts thereof.
Abstract: 1-alkyl-3-arylimidazolidine-2,4-diones are prepared by reacting the herbicidally active intermediate N-phenyl-2-substituted-2-alkylamino acetamides with 1,1'-carbonyldiimidazole in a suitable solvent. These herbicidally active intermediates are prepared by reacting alpha-haloacetanilides with the primary amine of choice in an alcohol solvent, in the presence or absence of water, at ambient temperature.
Abstract: Sunscreen compositions are described which contain certain cyclohexenylidene cyanoacetate esters and amides which act as UV filters when incorporated in a carrier in amounts ranging from 0.1-50% by weight.
Type:
Grant
Filed:
December 28, 1988
Date of Patent:
January 2, 1990
Assignee:
ICI Americas Inc.
Inventors:
Donald J. Gosciniak, Thomas P. Cleary, Charlambos J. Phalangas
Abstract: Tetramethylpiperidyl terminated triazine oligomeric esters and amides having a plurality of tetramethyl piperidyl moieties are useful as polymer additives to impart resistance to degradation when exposed to actinic radiation.
Abstract: Sunscreen compositions are described which contain certain substituted naphthalenylidenes which act as UV filters when incorporated in a carrier in amounts ranging from 0.1-50% by weight.
Type:
Grant
Filed:
July 28, 1988
Date of Patent:
December 26, 1989
Assignee:
ICI Americas Inc.
Inventors:
Charalambos J. Phalangas, Thomas P. Cleary
Abstract: As new compounds, acylaminoaryloxy and arylthio pyrimidines having the formula ##STR1## wherein A is oxygen or sulfur; M is CH or N; X is hydrogen, lower alkyl, halo, methoxy, alkoxy, C.sub.1 -C.sub.3 alkylthio, cyano, carbomethoxy or trifluoromethyl; ##STR2## wherein R' is C.sub.1 -C.sub.8 straight, branched-chain or halo-alkyl, aryl; and R is hydrogen, C.sub.1 -C.sub.8 straight or branched chain alkyl, C.sub.5 or C.sub.6 cycloalkyl or aryl.
Abstract: Ortho-nitrobenzonitriles are produced from the corresponding ortho-nitrochlorobenzenes by reaction with cuprous cyanide and an alkali metal bromide, an alkaline earth metal bromide, or zinc bromide or with a combination of lithium cyanide and cuprous bromide, optionally in the presence of a solvent.
Abstract: The present invention comprises certain amide and ester derivatives of 4-substituted-cinnoline-3-carboxylic acids and 3-acyl-4-substituted-cinnoline derivatives, and their use as central nervous system (CNS) depressants.