Abstract: A high frame rate high definition imaging system and method are disclosed. An imager is clocked asynchronously to a desired output video clock. During a frame cycle, data held in a first portion of the pixel array in the imager is clocked out of the imager using an imager clock signal, and data held in a second portion of the pixel array is bypassed. The imager data is subsequently converted to a higher video clock rate and output as desired video data.