Abstract: Nucleic acid expression control sequence cassettes and vectors containing the same are provided for use in making abundant quantities of recombinant polypeptides of interest. The modified transcriptional control sequences, which include a T5 promoter sequence, are highly stable and can be used in a variety of vectors, such as plasmids.
Abstract: Compositions and methods for making and using therapeutic formulations of multivalent hybrid polypeptides comprising immunogenic peptides of M proteins from various different serotypes of group A streptococci and antibodies thereto are provided. Also provided are nucleic acids encoding such hybrid polypeptides. The hybrid polypeptide formulations may be used, for example, in methods for treating or preventing a microbial infection and eliciting a protective immune response having broadly protective opsonic antibodies in the absence of tissue cross-reactive antibodies.
Type:
Grant
Filed:
October 28, 2002
Date of Patent:
September 18, 2007
Assignees:
University of Tennessee Research Foundation, ID Biomedical Corporation of Washington
Inventors:
Mark A. Reddish, Mary ChaoHong Hu, Michael A. Walls, James B. Dale
Abstract: Nucleic acid expression control sequence cassettes and vectors containing the same are provided for use in making abundant quantities of recombinant polypeptides of interest. The modified transcriptional control sequences, which include a T5 promoter sequence, are highly stable and can be used in a variety of vectors, such as plasmids.
Type:
Application
Filed:
August 22, 2005
Publication date:
June 28, 2007
Applicant:
ID BIOMEDICAL CORPORATION OF WASHINGTON
Abstract: Nucleic acid expression control sequence cassettes and vectors containing the same are provided for use in making abundant quantities of recombinant polypeptides of interest. The modified transcriptional control sequences, which include a T5 promoter sequence, are highly stable and can be used in a variety of vectors, such as plasmids.
Type:
Application
Filed:
August 22, 2005
Publication date:
December 29, 2005
Applicant:
ID BIOMEDICAL CORPORATION OF WASHINGTON
Abstract: Nucleic acid expression control sequence cassettes and vectors containing the same are provided for use in making abundant quantities of recombinant polypeptides of interest. The modified transcriptional control sequences, which include a T5 promoter sequence, are highly stable and can be used in a variety of vectors, such as plasmids.
Abstract: Nucleic acid expression control sequence cassettes and vectors containing the same are provided for use in making abundant quantities of recombinant polypeptides of interest. The modified transcriptional control sequences, which include a T5 promoter sequence, are highly stable and can be used in a variety of vectors, such as plasmids.
Type:
Application
Filed:
October 28, 2002
Publication date:
July 31, 2003
Applicant:
ID BIOMEDICAL CORPORATION OF WASHINGTON