Abstract: The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
Type:
Grant
Filed:
May 22, 2014
Date of Patent:
January 26, 2016
Assignee:
Idera Pharamaceuticals, Inc.
Inventors:
Ekambar R. Kandimalla, Tao Lan, Yukui Li, Dong Yu, Daqing Wang, Mallikarjuna Putta, Sudhir Agrawal