Abstract: The present disclosure is directed to methods and systems for verifying biological analysis devices. The method includes calibrating a hematology device utilizing at least one of a quality control sample or historical patient data, generating diagnostic data associated with a portion of a biological sample with the hematology device, the diagnostic data comprising a first group of attributes associated with the biological sample, identifying whether the first group of attributes is within predetermined parameters, capturing an image of another portion of the biological sample with a microscopy device, identifying a second group of attributes associated with the biological sample based at least in part on the image, and determining one or more verification parameters based on the second group of attributes.

Abstract: A collection device for examining fecal matter to determine whether a patient is afflicted with parasites includes a particle accumulating plug mounted on an end of a collection tube containing a fecal specimen. The particle accumulating plug includes an inner wall that defines an inverted funnel. A pipetting port is formed through the inner wall at the apex of the inverted funnel allowing the tip of a pipette to enter the port and aspirate the ova or eggs, or other parasite cells, that have separated from the fecal specimen. The conical shape of the inner wall of the plug directs the separated parasite ova or eggs towards the pipetting port and to accumulate within the volume of the funnel of the plug so that a desired volume of fluid containing a concentrated quantity of parasite ova or eggs may be aspirated into the pipette tip through the pipetting port.

Abstract: Systems and methods for use with a biological sample include a microscopy device, a diluent, a sample holder, and one or more of lyophilized cakes comprising artificial particles. The lyophilized cakes and the biological sample are mixed with the diluent in the sample holder to form a solution. The biological sample is imaged with the artificial particles as reference markers using the microscopy device. A settling time of the artificial particles is shorter than or equal to a settling time of the biological sample.

Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.

Abstract: A collection device for examining fecal matter to determine whether a patient is afflicted with parasites includes a particle accumulating plug mounted on an end of a collection tube containing a fecal specimen. The particle accumulating plug includes an inner wall that defines an inverted funnel. A pipetting port is formed through the inner wall at the apex of the inverted funnel allowing the tip of a pipette to enter the port and aspirate the ova or eggs, or other parasite cells, that have separated from the fecal specimen. The conical shape of the inner wall of the plug directs the separated parasite ova or eggs towards the pipetting port and to accumulate within the volume of the funnel of the plug so that a desired volume of fluid containing a concentrated quantity of parasite ova or eggs may be aspirated into the pipette tip through the pipetting port.

Abstract: Rocky Mountain Spotted Fever (RMSF) is a vector borne disease that is caused by Rickettsia rickettsii infection. It is challenging to identify the disease in dogs and other mammals due to the cross-reacting antibodies from non-pathogenic Rickettsia spp. Provided herein are compositions and methods for detection and treatment of Rocky Mountain spotted fever (“RMSF”). The compositions specifically detect Rickettsia rickettsii and do not cross-react with other Rickettsia species providing rapid and accurate detection and diagnosis of RMSF.

Abstract: The systems and methods of flexible and customizable wellness program plan for pets through a distribution network connecting pet-owners, manufacturers, clinics and veterinarians, comprising: customizing a wellness plan to include one or more of the following parameters: frequency of services including exams or bloodwork, frequency of products used including vaccinations or preventatives and frequency of payments; customizing payment frequency for veterinarians for services rendered; tracking commissions to manufacturers for products used; tracking profitability for clinics implementing the wellness program; tracking wellness program plan usage by a pet; tracking enrollment and expiry status of a wellness program plan for a pet; dynamically reporting to one or more of the following: manufacturer, clinic, veterinarian or pet-owner.

Abstract: A flow cytometer of a blood analyzer including a transverse-electric (TE) laser diode, a flow cell, a quarter wave plate (QWP), a plurality of lenses, and a side scatter detector. The TE laser diode is configured to output a laser beam along an optical axis and has a fast axis full width at half maximum (FWHM) divergence of from about 16 degrees to about 25 degrees. The QWP is disposed along the optical axis between the TE laser diode and the flow cell and configured to circularly polarize the laser beam. The plurality of lenses is disposed between the TE laser diode and the flow cell and configured to focus the laser beam at the flow cell.

Abstract: An example method includes receiving a first order to conduct a first diagnostic test of a sample from a patient, sending the first order to the first diagnostic testing instrument for input into a queue of the first diagnostic testing instrument, receiving alerts and status of the diagnostic test as testing is performed and for indication of completion of the first diagnostic test, sending the alerts and status of the diagnostic test to a second computing device for notice to a technician, receiving an output of the first diagnostic test, generating a recommendation of follow-on testing to perform based on the output of the first diagnostic test, receiving confirmation to perform the follow-on testing, generating a second order to conduct a second diagnostic test of another sample from the patient, and sending the second order to the second diagnostic testing instrument for input into a queue for the second diagnostic testing instrument.

Abstract: An example method includes capturing, via an x-ray machine, a plurality of x-ray images of a patient covering a number of different anatomy of the patient in any order, using a machine learning algorithm to process the plurality of x-ray images for identification of an anatomy in respective x-ray images of the plurality of x-ray images, associating a label with each of the plurality of x-ray images based on the identification of the anatomy, positioning each of the plurality of x-ray images upright based on a preset coordinate scheme for the anatomy, arranging the plurality of x-ray images into a predetermined order based on the species of the patient, and generating and outputting a data file including the plurality of x-ray images in the predetermined order, positioned upright, and labeled.

Abstract: A method of measuring the degree of Z-axis variability in a chemical reagent test slide, which includes the steps of placing a Z-axis measurement fixture on a surface of a gauge block of an optical measurement system having a camera, mounting the chemical reagent test slide on the Z-axis measurement fixture, and positioning the chemical reagent test slide mounted on the Z-axis measurement fixture in optical communication with the camera.

Abstract: Provided herein are compositions and methods for detection of detection and treatment of Mycoplasma haemofelis and Mycoplasma haemocanis.

Abstract: A method for calibrating sensitivity of a photometer includes measuring, by a double-beam spectrophotometer, an absorbance spectrum of a control solution, which has been diluted and includes a control substance. The method further includes linearly regressing the absorbance spectrum of the control solution over a predetermined range of wavelengths and determining whether a first slope of the linearly regressed absorbance spectrum of the control solution falls within a range of slopes of lines obtained from linearly regressing absorbance spectra of a plurality of reference solutions over the predetermined range of wavelengths. A concentration of chromophore in each reference solution is known and the absorbance spectra of the plurality of reference solutions have been obtained by the double-beam spectrophotometer.

Abstract: A culture dish includes a base and a lid. The base includes a side wall and a concave floor that define a first interior volume open at a top end of the base. The base further includes an annular rim between the floor and a bottom end thereof. The lid includes a side wall and a ceiling that define a second interior volume open at a bottom end of the lid. The lid further includes an annular rim extending radially outwardly therefrom. An inner surface of the side wall of the lid is configured for slidable receipt about an outer surface of the side wall of the base to engage the lid about the base with the first and second interior volumes overlapping one another to define a sealed, combined internal volume bounded by the side walls of the base and the lid, the floor, and the ceiling.

Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.

Abstract: The disclosure relates generally to methods for measuring bacteria in biological samples. More particularly, the disclosure relates to methods for measuring bacteria using an aqueous clearance solution.

Abstract: An example computer-implemented method of increasing veterinary health care compliance includes receiving information indicating that an animal patient concluded a visit at a veterinary practice, in response accessing diagnostic test results for the animal patient, based on the diagnostic test results creating a pet owner profile for an owner of the animal patient, matching the pet owner profile with a stored message and stored information relating to a product associated with recommended treatment for the animal patient, sending an electronic message to a second computing device associated with the owner of the animal patient that includes the stored message and the stored information relating to the product associated with recommended treatment for the animal patient, receiving a report indicating whether the owner of the animal patient obtained the product associated with recommended treatment for the animal patient, and updating the pet owner profile to be indicative of the report.

Abstract: A system and method for retrieving data from a data generating device includes a communication intermediary and an external data storage system. The communication intermediary has a first network interface that is connected to the external data storage system and a second network interface that is connected to the data generating device. The communication intermediary isolates the network communication between the data generating device and second network interface from the network communication between the external storage system and the first network interface, and thereby isolates the data generating device from the external storage system. The communication intermediary monitors the data generating device for newly generated data files, copies the newly generated data files to an internal memory and sends the data files to the external storage system.