Abstract: The present invention relates to ex vivo methods using a compound selected from the group consisting of azacytidine, a compound of formula (I): and decitabine, a compound of formula (II): and related uses of said compounds.
Abstract: A composition and method for using a composition, the composition having at least two compounds, each of which induces indolamine 2,3-dioxygenase, for the treatment of an autoimmune disorder or disease or immune rejection of transplants or gene therapeutically modified cells, wherein the inducers have different mechanism of action and wherein the composition gives rise to a synergistic effect on the IDO levels.
Type:
Grant
Filed:
November 25, 2014
Date of Patent:
December 12, 2017
Assignee:
Idogen AB
Inventors:
Leif Salford, Hans Olov Sjogren, Bengt Widegren
Abstract: A composition and method for using a composition, the composition having at least two compounds, each of which induces indolamine 2,3-dioxygenase, for the treatment of an autoimmune disorder or disease or immune rejection of transplants or gene therapeutically modified cells, wherein the inducers have different mechanism of action and wherein the composition gives rise to a synergistic effect on the IDO levels.
Type:
Application
Filed:
December 20, 2011
Publication date:
November 21, 2013
Applicant:
IDOGEN AB
Inventors:
Leif Salford, Hans Olov Sjogren, Bengt Widegren