Abstract: A hand rehabilitation device is used in rehabilitation therapies, for motility and functionality of the hands. The device has an orthosis, fitted to partially cover a patient's hand and forearm, and flexible rods for a passive and assisted active, concurrent, and/or selective bending or extension of the fingers. Movements are freely settable by an operator. Elements for sliding and supporting of the flexible rods during bending or extension of the fingers include ‘finger socks” or gloves provided with thimbles, fixed rods, or plates to stabilize the thimbles and hinged to move the flexible rods. A movement/command and control unit, integral to, or remoted located relative to, the orthosis is provided with actuators for moving the flexible rods. A tension adjusts the rods and rehabilitation device, adjusting and adapting to the hand s anatomical features.