Abstract: The present invention relates to tricyclic derivatives of formula (I), which are useful as inhibitors of HECT-domain-containing E3 ligases, in particular NEDD4. The present invention also refers to pharmaceutical compositions comprising compounds of formula (I), to their medical use and to their process of preparation.
Type:
Application
Filed:
June 3, 2020
Publication date:
October 27, 2022
Applicants:
IFOM - FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE, IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L.
Inventors:
Sebastiano PASQUALATO, Maurizio PASI, Raffaella AMICI, Mario VARASI, Ciro MERCURIO, Luca SARTORI, Simona POLO, Elena MASPERO, Giovanni FAGA'
Abstract: The present disclosure refers to a method for identifying an immunoglobulin, recombinant or synthetic antigen-binding fragments thereof that present in vivo tumor binding activity and do not significantly cross-react with normal cells and to antibodies thereby obtained and to medical uses thereof
Type:
Application
Filed:
June 19, 2019
Publication date:
May 27, 2021
Applicant:
IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L.
Inventors:
Luisa LANFRANCONE, Paul Edward MASSA, Massimiliano MAZZA, Pier Giuseppe PELICCI
Abstract: It is disclosed a method for obtaining a specific tumor antigen peptide repertoire loaded and/or activated dendritic cell comprising the steps of: a) exposing in suitable conditions a tumor cell expressing said specific tumor antigen peptide repertoire to at least one Pattern Recognition Receptor (PRR) agonist and/or to an inflammatory cytokine to obtain a tumor cell with an increased activity of at least one protein belonging to the group of connexins; b) co-culturing said tumor cell with an increased activity of at least one protein belonging to the group of connexins with dendritic cells, to get specific tumor antigen peptide repertoire loaded and/or activated dendritic cells; Step a) and b) are performed simultaneously or in sequence. The group of connexins preferably consists of connexin 43, connexin 40, connexin 45, connexin 47, connexin 50.
Type:
Application
Filed:
August 4, 2011
Publication date:
May 23, 2013
Applicant:
IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L.