Abstract: An electroporation device adapted to perform the following operations: detect the resistance value RA,B between a pair of electrodes placed in a portion of human tissue; calculate, select and store a pair of values of total duration ?(n,t) and voltage V that satisfy the inequality: ? · [ ( V / d ) ] 2 · ? ? ( n , t ) ? > A ? D R where: ADR represents the energy dose that realises a reversible electroporation—the energy dose ADR is a known value stored in the device; ? is defined as the inverse of resistivity ?=1/; d is the spacing of the electrodes; the resistivity =R*S/d where R denotes the measured and stored resistance value and S the section of the electrodes; and control a power amplifier so that a voltage equal to the voltage V is applied to the electrodes and supplied to the tissue portion for the determined total duration ?.

Abstract: There is disclosed a method for the treatment of cerebral ischemic stroke in a subject in need thereof comprising the steps of (a) identifying an ischemic area of the brain of the subject; and (b) applying an effective electromagnetic field to the ischemic area of the brain, wherein the electromagnetic field is effective to reduce local edema, to increase neuronal survival and/or reduce neuronal apoptosis.

Abstract: A handling and control system for expandable electrodes of a handpiece is provided that includes a plurality of flexible electrodes made of elastic cables carried by a support assembly with needle-shaped front portions that protrude from the support assembly and move in a three-dimensional space under the push of actuators.

Abstract: A method for controlling an electroporation device configured for supplying an electrical power signal to a plurality of pairs of electrodes coupled to a portion of the human body, wherein the following steps are performed: detecting, in the course of an electroporation treatment, a condition of malfunctioning or fail for the pairs of electrodes for which at least one electrical parameter of the power signal supplied to the electrodes themselves has an anomalous value; storing an indicator of the pairs of electrodes in the fail condition; and selecting the pairs of electrodes in the fail condition and re-computing new parameters in order to implement a subsequent electroporation process.

Abstract: Hand held adjustable device comprising: a grip provided with an end portion; a plurality of needles which extend axially from the end portion and are made of electrically conductive material, and a device for adjusting the insertion depth of the needles in a tissue in which a cup-shaped body borne by said end portion of the grip is provided with an end wall having holes for the passage of said needles. A system for adjustment of the relative position between the cup-shaped body and the end portion provides an axial sliding of the cup-shaped body with respect to the end portion adjust the length of the portion of the needles protruding from said end wall and therefore the insertion depth in the tissue.

Abstract: Hand held adjustable device comprising: a grip provided with an end portion; a plurality of needles which extend axially from the end portion and are made of electrically conductive material, and a device for adjusting the insertion depth of the needles in a tissue in which a cup-shaped body borne by said end portion of the grip is provided with an end wall having holes for the passage of said needles. A system for adjustment of the relative position between the cup-shaped body and the end portion provides an axial sliding of the cup-shaped body with respect to the end portion adjust the length of the portion of the needles protruding from said end wall and therefore the insertion depth in the tissue.