Abstract: Antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, tubulysin analogs, and intermediates in their synthesis; compositions; and methods, including methods of treating cancers.
Abstract: The invention provides antibodies that bind C16orf54, including antibody-drug conjugates comprising the antibodies, and methods of use of the antibodies and the antibody-drug conjugates, including for the diagnosis and treatment of cancers.
Type:
Application
Filed:
October 9, 2013
Publication date:
August 20, 2015
Applicant:
IGENICA BIOTHERAPEUTICS, INC.
Inventors:
Guoqing Chen, Sun Young Kim, Jan-Willem Theunissen, Edward Thein-Htun Van Der Horst, David Jackson, Edward Ha, John Lippincott
Abstract: Antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, tubulysin analogs, and intermediates in their synthesis; compositions; and methods, including methods of treating cancers.
Type:
Application
Filed:
June 6, 2014
Publication date:
December 11, 2014
Applicant:
Igenica Biotherapeutics, Inc.
Inventors:
David Y. Jackson, Edward Ha, Gary D. Probst