Abstract: Hardware and software methodology are described including a synthesized User Interface (UI) to provide guidance for injection and other procedures under medical imaging. The UI provides a practitioner the option of viewing multiple images concurrent with a live image. A guidance image corresponds to correct probe placement for a selected procedure, a reference image corresponds to an expected view with such probe placement in the live image. The reference image may be variously labeled. Another option involves probe tracking to update the guidance and/or reference image view(s).