Abstract: The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.
Type:
Application
Filed:
February 15, 2013
Publication date:
July 25, 2013
Applicants:
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, IGR&D SA, UNIVERSITE PARIS-SUD, INSTITUT GUSTAVE-ROUSSY, UNIVERSITE DE VERSAILLES - ST QUENTIN EN YVELINES, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Inventors:
Assistance Publique - Hopitaux De Paris, IGR&D SA, Institut National De La Sante Et De La Recherche Medicale (INSERM), Institut Gustave-Roussy, Universite De Versailles - St Quentin En Yvelines, Universite Paris-Sud