Patents Assigned to Ikaria, Inc.
  • Publication number: 20140287066
    Abstract: The present invention is directed to dosing regimens for the administration of carbon monoxide in the treatment of various indications as well as methods for enhancing organ function following transplant thereof.
    Type: Application
    Filed: June 9, 2014
    Publication date: September 25, 2014
    Applicant: IKARIA, INC.
    Inventors: Helen H. Usansky, Khurram Jamil
  • Patent number: 8778413
    Abstract: The present invention is directed to dosing regimens for the administration of carbon monoxide in the treatment of various indications as well as methods for enhancing organ function following transplant thereof.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: July 15, 2014
    Assignee: Ikaria, Inc.
    Inventors: Helen H. Usansky, Khurram Jamil
  • Patent number: 8226986
    Abstract: The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: July 24, 2012
    Assignee: Ikaria, Inc.
    Inventors: Kevin J. Tomaselli, Paul A. Hill, Thomas L. Deckwerth, Edward A. Wintner, Csaba Szabo
  • Patent number: 8202997
    Abstract: A method for treating or preventing injury of a biological material exposed to hypoxic or ischemic conditions comprising contacting the biological material with an effective amount of a compound is disclosed. The compound has the following structure (I): R1—(S)n—R2 ??(I) or a stereoisomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, and n are as defined herein. Compounds, methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: June 19, 2012
    Assignee: Ikaria, Inc.
    Inventors: Edward A. Wintner, Fuqiang Ruan
  • Publication number: 20120042876
    Abstract: Methods and systems for delivering a pharmaceutical gas to a patient. The methods and systems provide a known desired quantity of the pharmaceutical gas to the patient independent of the respiratory pattern of the patient over a plurality of breaths every nth breath, where n is greater than or equal to 1. The pharmaceutical gases include CO and NO, both of which are provided as a concentration in a carrier gas. The gas control system determines the delivery of the pharmaceutical gas to the patient to result in the known desired quantity (e.g. in molecules, milligrams or other quantified units) of the pharmaceutical gas being delivered. Upon completion of that known desired quantity of pharmaceutical gas over a plurality of breaths, the system can either terminate, continue, activate and alarm, etc.
    Type: Application
    Filed: November 2, 2011
    Publication date: February 23, 2012
    Applicant: Ikaria, Inc.
    Inventors: Frederick J. Montgomery, Duncan P.L. Bathe
  • Publication number: 20120042875
    Abstract: Methods and systems for delivering a total quantity of pharmaceutical gas to a patient. The methods and systems provide one of a low amount and high amount of pharmaceutical gas to a patient. The selection of the high amount or low amount may be determined by comparing the amount per unit of time of pharmaceutical gas delivered to the patient over the past number of breaths to the required quantity of pharmaceutical gas per unit of time. Upon completion of delivering the total quantity of pharmaceutical gas to the patient, the system can terminate, continue, activate and alarm, etc.
    Type: Application
    Filed: October 28, 2011
    Publication date: February 23, 2012
    Applicant: Ikaria, Inc.
    Inventors: Frederick J. Montgomery, Duncan P. L. Bathe
  • Publication number: 20110217226
    Abstract: Method and apparatus of making 99.99% pure gaseous carbon monoxide comprising the steps of degassing liquid formic acid producing degassed liquid formic acid; reacting the degassed liquid formic acid or a degassed gaseous formic acid with a liquid mineral acid at an elevated temperature producing a gas phase comprising carbon monoxide gas and water vapor and a liquid phase; condensing the gas phase producing liquid water and gaseous carbon monoxide; scrubbing the carbon monoxide gas producing a gaseous 99.99% pure carbon monoxide having a purity of at least 99.99%, and, compressing the gaseous 99.99% pure carbon monoxide producing the 99.
    Type: Application
    Filed: March 2, 2011
    Publication date: September 8, 2011
    Applicant: Ikaria, Inc.
    Inventors: Tammer Mosa, Gerard T. Taylor
  • Publication number: 20110195945
    Abstract: Compositions and methods of treating or preventing disease or injury to a human patient or biological material undergoing ischemic or hypoxic conditions.
    Type: Application
    Filed: February 11, 2011
    Publication date: August 11, 2011
    Applicant: Ikaria, Inc.
    Inventors: Fuqiang Ruan, Edward A. Wintner, Thomas L. Deckwerth
  • Publication number: 20110162994
    Abstract: The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 7, 2011
    Applicant: Ikaria, Inc.
    Inventors: Kevin J. Tomaselli, Paul A. Hill, Thomas L. Deckwerth, Edward Wintner, Csaba Szabo
  • Publication number: 20110165268
    Abstract: The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 7, 2011
    Applicant: Ikaria, Inc.
    Inventors: Kevin J. Tomaselli, Paul A. Hill, Thomas L. Deckwerth, Edward Wintner, Csaba Szabo
  • Patent number: 7945301
    Abstract: The present invention relates to a method and apparatus for the administration of carbon monoxide (CO) to a patient. It allows the safe and effective use of carbon monoxide as a medicament.
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: May 17, 2011
    Assignee: Ikaria, Inc.
    Inventors: Christian Krebs, Rainer Müllner
  • Patent number: 7923037
    Abstract: The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: April 12, 2011
    Assignee: Ikaria, Inc.
    Inventors: Kevin J. Tomaselli, Paul A. Hill, Thomas L. Deckwerth, Edward Wintner, Csaba Szabo
  • Publication number: 20100183748
    Abstract: Methods for treating or preventing radiocontrast agent induced kidney injury in a mammal are disclosed, the methods comprising administering to the mammal a first effective amount of a chalcogenide composition prior to administering a radiocontrast agent to the mammal.
    Type: Application
    Filed: January 20, 2010
    Publication date: July 22, 2010
    Applicant: Ikaria, Inc.
    Inventors: Chienmin Su, Csaba Szabo
  • Publication number: 20100143503
    Abstract: The present invention provides methods of reducing the cytotoxic effects of nitric oxide and sulfides comprising coadministering nitric oxide with sulfide. In addition, the present invention provides novel pharmaceutical compositions comprising both nitric oxide and sulfide. The methods and compositions of the present invention may be used in the treatment or prevention of a variety of diseases and disorders, and also in the prevention of cell or tissue damage, including that resulting from ischemi hypoxia.
    Type: Application
    Filed: December 20, 2007
    Publication date: June 10, 2010
    Applicant: Ikaria, Inc.
    Inventors: Csaba Szabo, Kevin James Tomaselli
  • Publication number: 20100130555
    Abstract: A method for treating or preventing injury of a biological material exposed to hypoxic or ischemic conditions comprising contacting the biological material with an effective amount of a compound is disclosed. The compound has the following structure (I): R1—(S)n—R2 ??(I) or a stereoisomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, and n are as defined herein. Compounds, methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: October 16, 2009
    Publication date: May 27, 2010
    Applicant: Ikaria, Inc.
    Inventors: Edward A. Wintner, Fuqiang Ruan
  • Publication number: 20080187604
    Abstract: The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
    Type: Application
    Filed: October 5, 2007
    Publication date: August 7, 2008
    Applicant: IKARIA, INC.
    Inventors: Kevin J. Tomaselli, Paul A. Hill, Thomas L. Deckwerth, Edward Wintner, Csaba Szabo
  • Publication number: 20070265223
    Abstract: The present invention provides methods, compositions, and articles of manufacture comprising adenosine, an adenosine derivative or analog, an adenosine receptor agonist, a chemical entity that is taken up by a nucleoside transporter, or a chemical entity that binds to and/or modulates a nucleoside transporter, which protect biological material from cellular or tissue damage resulting from ischemia or hypoxia, including ischemia and hypoxia due to injury, disease, or hemorrhaging. These methods, compositions, and articles of manufacture also enhance the survivability of biological material subjected to ischemia due to injury, disease, or hemorrhage.
    Type: Application
    Filed: March 12, 2007
    Publication date: November 15, 2007
    Applicant: IKARIA, INC.
    Inventors: Kevin Tomaselli, Thomas Deckwerth