Patents Assigned to ILEX Products, Inc.
  • Aminodiphosphonate apolipoprotein E modulators
    Patent number: 7208481
    Abstract: The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: April 24, 2007
    Assignee: ILEX Products, Inc.
    Inventors: Hieu Trung Phan, Lân Mong Nguyen, Raymond Azoulay, Vinh Van Diep, Eric Joseph Niesor, Craig Leigh Bentzen, Yves Gyon Gellin, Anne Perez, Jean-Luc Thulliard
  • Tumor chemopotentiation using isocoumarin derivatives
    Patent number: 6900239
    Abstract: A method for enhancing the efficacy of chemotherapy in the treatment of cancer in animals, particularly humans, is provided wherein isocoumarin derivatives that exhibit unique chemopotentiation properties are employed in a combination treatment with chemotherapy.
    Type: Grant
    Filed: February 23, 2002
    Date of Patent: May 31, 2005
    Assignee: ILWZ ILEX Products, Inc.
    Inventors: Naoki Agata, Surender Kharbanda
  • Process for preparing homophthalate derivatives
    Patent number: 6797838
    Abstract: The present invention provides a process for the preparation of homophthlate esters useful in the preparation of homophthalic anhydride reactants.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: September 28, 2004
    Assignee: Ilex Products, Inc.
    Inventors: William E. Bauta, William R. Cantrell, Jr., Dennis P. Lovett
  • &agr;-Substituted &bgr;-aminoethyl phosphonate derivatives
    Patent number: 6706698
    Abstract: The present invention relates to novel &agr;-substituted-&bgr;-aminoethylphosphonate and &agr;-substituted-&bgr;-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: March 16, 2004
    Assignee: Ilex Products, Inc.
    Inventors: Hieu Trung Phan, Lan Mong Nguyen, Vinh Van Diep, Raymond Azoulay, Harald Eschenhof, Eric Joseph Niesor, Craig Leigh Bentzen, Robert John Ife
  • Process for preparing purine nucleosides
    Patent number: 6680382
    Abstract: The present invention provides for the preparation &bgr;-adenine nucleosides by coupling an adenine derivative containing an unprotected exocyclic amino group at the C-6 position and a blocked arabinofuranosyl derivative, in the presence of a base and solvent. The present invention also provides for the stereoselective preparation of 2-deoxy-&bgr;-D-adenine nucleosides wherein a blocked 2-deoxy-&agr;-D-arabinofuranosyl halide is coupled with the salt of an adenine derivative. The forgoing aspects of the present invention are utilized in the preparation of a clofarabine composition wherein the ratio of &bgr; to &agr;-anomer is at least 99:1.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: January 20, 2004
    Assignee: Ilex Products, Inc.
    Inventors: William E. Bauta, Brian D. Burke, Brian E. Schulmeier, William R. Cantrell, Jr., Dennis P. Lovett, Jose Puente
  • Process for preparing isocoumarins
    Patent number: 6664401
    Abstract: The present invention provides a process from preparing isocoumarin-3-yl derivatives comprising reacting a homophthalic anhydride derivative with a carbonyl compound, wherein the carbonyl group is substituted with an acyl activating group, in the presence of a reaction medium comprising a solvent and a base. The invention also encompasses a process for the preparation of homophthalate esters useful in the preparation of homophthalic anhydride reactants as well as an integrated process wherein the twp reactions are carried out sequentially to afford the desired isocoumarin derivative.
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: December 16, 2003
    Assignee: ILEX Products, Inc.
    Inventors: William E. Bauta, William R. Cantrell, Jr., Dennis P. Lovett
  • Compounds and pharmaceutical compositions containing them
    Patent number: 6660724
    Abstract: Aminophosphonates alpha substituted by phenol groups of formula (I) have lipoprotein(a) lowering activity.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: December 9, 2003
    Assignee: Ilex Products, Inc.
    Inventors: Lan Mong Nguyen, Eric Niesor, Craig Leigh Bentzen, Hieu Trung Phan, Vinh Van Diep, Simon Floret, Raymond Azoulay, Alexandre Bulla, Yves Guyon-Gellin, Robert John Ife