Abstract: This invention relates to a method of inhibiting Fc receptor binding of immunoglobulin including the use of a Fc receptor modulating compound which binds to defined surfaces on a Fc receptor. The present invention also relates to a method for treating a variety of diseases using a Fc receptor modulating compound.
Type:
Grant
Filed:
June 3, 2004
Date of Patent:
June 30, 2009
Assignee:
Ilexus Pty Limited
Inventors:
Jonathan B. Baell, Thomas P. J. Garrett, P. Mark Hogarth, Barry R. Matthews, Thomas D. McCarthy, Geoffrey A. Pietersz, Maree S. Powell, Ian F. C. McKenzie, Kelly F. Maxwell, Vidana Epa
Abstract: Methods for inhibiting Fc receptor binding of immunoglobulin in a patient comprising administering pharmaceutical compositions comprising Fc modulating compounds are disclosed.
Type:
Grant
Filed:
November 26, 2001
Date of Patent:
December 28, 2004
Assignee:
Ilexus Pty Limited
Inventors:
Jonathan B. Baell, Thomas P. J. Garrett, P. Mark Hogarth, Barry R. Matthews, Thomas D. McCarthy, Geoffrey A. Pietersz
Abstract: Disclosed are crystals, crystal structure Fc&ggr;RIIa protein, three dimensional coordinates of Fc&ggr;RIIa protein, and structures and models derived from the Fc&ggr;RIIa structure. Also disclosed are crystals of Fc&egr;RI protein and three dimensional coordinates of Fc&egr;RI protein monomers and dimers derived from the Fc&ggr;RIIa structure. Also disclosed are three dimensional coordinates of Fc&ggr;RIIIb proteins and models of Fc&ggr;RIIIb derived from the Fc&ggr;RIIa structure. The present invention also includes methods to produce such crystals, crystal structures and models. Uses of such crystals, crystal structures and models are also disclosed, including structure based drug design and therapeutic compositions.
Type:
Application
Filed:
October 15, 2003
Publication date:
March 18, 2004
Applicant:
Ilexus Pty Limited
Inventors:
P. Mark Hogarth, Maree S. Powell, Ian F.C. McKenzie, Kelly F. Maxwell, Thomas P.J. Garrett, Vidana Epa
Abstract: Disclosed are crystals, crystal structure Fc&ggr;RIIa protein, three dimensional coordinates of Fc&ggr;RIIa protein, and structures and models derived from the Fc&ggr;RIIa structure. Also disclosed are crystals of Fc&egr;RI protein and three dimensional coordinates of Fc&egr;RI protein monomers and dimers derived from the Fc&ggr;RIIa structure. Also disclosed are three dimensional coordinates of Fc&ggr;RIIIb proteins and models of Fc&ggr;RIIIb derived from the Fc&ggr;RIIa structure. The present invention also includes methods to produce such crystals, crystal structures and models. Uses of such crystals, crystal structures and models are also disclosed, including structure based drug design and therapeutic compositions.
Type:
Grant
Filed:
February 5, 1999
Date of Patent:
January 6, 2004
Assignee:
Ilexus Pty Limited
Inventors:
P. Mark Hogarth, Maree S. Powell, Ian F. C. McKenzie, Kelly F. Maxwell, Thomas P. J. Garrett, Vidana Epa
Abstract: This invention relates to a pharmaceutical composition comprising a Fc receptor modulating compound and a pharmaceutically acceptable carrier. The present invention also relates to a method for treating a variety of diseases using a Fc receptor modulating compound.
Type:
Application
Filed:
November 26, 2001
Publication date:
May 23, 2002
Applicant:
Ilexus Pty Limited
Inventors:
Jonathan B. Baell, Thomas P.J. Garrett, P. Mark Hogarth, Barry R. Matthews, Thomas D. McCarthy, Geoffrey A. Pietersz
Abstract: This invention relates to a pharmaceutical composition comprising a Fc receptor modulating compound and a pharmaceutically acceptable carrier. The present invention also relates to a method for treating a variety of diseases using a Fc receptor modulating compound.
Type:
Grant
Filed:
September 10, 1999
Date of Patent:
March 12, 2002
Assignee:
Ilexus Pty Limited
Inventors:
Jonathan B. Baell, Thomas P. J. Garrett, P. Mark Hogarth, Barry R. Matthews, Thomas D. McCarthy, Geoffrey A. Pietersz