Patents Assigned to Ilypsa, Inc.
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Patent number: 8349305Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.Type: GrantFiled: May 27, 2008Date of Patent: January 8, 2013Assignee: Ilypsa, Inc.Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
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Patent number: 7767768Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.Type: GrantFiled: May 11, 2005Date of Patent: August 3, 2010Assignee: Ilypsa, Inc.Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
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Patent number: 7754199Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.Type: GrantFiled: April 11, 2007Date of Patent: July 13, 2010Assignee: Ilypsa, Inc.Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
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Patent number: 7718746Abstract: Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.Type: GrantFiled: May 22, 2009Date of Patent: May 18, 2010Assignee: Ilypsa, Inc.Inventors: Eric Connor, Dominique Charmot, Han-Ting Chang, Florence Roger, Gerrit Klaerner, Son Hoai Nguyen, Jonathan Mills, Jerry M. Buysse, Angela Lee, Deidre Madsen, Jun Shao, Michael J. Cope, John Fordtran
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Patent number: 7666898Abstract: Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.Type: GrantFiled: November 3, 2006Date of Patent: February 23, 2010Assignee: Ilypsa, Inc.Inventors: Han-Ting Chang, Dominique Charmot, Tomasz Glinka, Michael James Cope, Elizabeth Goka, Jun Shao, Damien Cartigny, Shiah-yun Chen, Jerry M. Buysse
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Publication number: 20100029897Abstract: Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.Type: ApplicationFiled: May 22, 2009Publication date: February 4, 2010Applicant: Ilypsa, Inc.Inventors: Eric Connor, Dominique Charmot, Han-Ting Chang, Florence Roger, Gerrit Klaerner, Son Hoai Nguyen, Jonathan Mills, Jerry M. Buysse, Angela Lee, Deidre Madsen, Jun Shao, Michael J. Cope, John Fordtran
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Patent number: 7608674Abstract: Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.Type: GrantFiled: November 3, 2004Date of Patent: October 27, 2009Assignee: Ilypsa, Inc.Inventors: Eric Connor, Dominique Charmot, Han-Ting Chang, Florence Roger, Gerrit Klaerner, Son Hoai Nguyen, Jonathan Mills, Jerry M. Buysse, Angela Lee, Deidre Madsen, Jun Shao, Michael J. Cope, John Fordtran
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Patent number: 7589238Abstract: Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.Type: GrantFiled: August 17, 2006Date of Patent: September 15, 2009Assignee: Ilypsa, Inc.Inventors: Eric Connor, Dominique Charmot, Han Ting Chang, Florence Roger, Gerrit Klaemer, Son Hoai Nguyen, Jonathan Mills, Jerry M. Buysse, Angela Lee, Deidre Madsen, Jun Shao, Michael J. Cope, John Fordtran
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Patent number: 7459502Abstract: Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.Type: GrantFiled: October 13, 2004Date of Patent: December 2, 2008Assignee: Ilypsa, Inc.Inventors: Eric Connor, Dominique Charmot, Han Ting Chang, Florence Roger, Gerrit Klearner, Son Hoai Nguyen
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Patent number: 7449605Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.Type: GrantFiled: March 22, 2005Date of Patent: November 11, 2008Assignee: Ilypsa, Inc.Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
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Publication number: 20080233079Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.Type: ApplicationFiled: May 27, 2008Publication date: September 25, 2008Applicant: Ilypsa, Inc.Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
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Patent number: 7385012Abstract: The present invention provides polymeric and pharmaceutical compositions comprising a polymer that contains vicinal amine moieties, referred to as polyvicinalamine polymers. The polyvicinalamines can be copolymers or homopolymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases, hyperphosphatemia, and the removal of bile acids, oxalates and iron from the gastrointestinal tract.Type: GrantFiled: November 3, 2003Date of Patent: June 10, 2008Assignee: Ilypsa, Inc.Inventors: Han Ting Chang, Dominique Charmot, Samir Zard
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Publication number: 20080107737Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.Type: ApplicationFiled: May 11, 2005Publication date: May 8, 2008Applicant: ILYPSA, INC.Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
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Patent number: 7342083Abstract: The present invention provides polymeric and pharmaceutical compositions comprising a polymer that contains vicinal amine moieties, referred to as polyvicinalamine polymers. The polyvicinalamines can be copolymers or homopolymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases, hyperphosphatemia, and the removal of bile acids, oxalates and iron from the gastrointestinal tract.Type: GrantFiled: November 3, 2004Date of Patent: March 11, 2008Assignee: Ilypsa, Inc.Inventors: Han Ting Chang, Dominique Charmot, Samir Zard
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Patent number: 7335795Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.Type: GrantFiled: March 22, 2004Date of Patent: February 26, 2008Assignee: Ilypsa, Inc.Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
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Publication number: 20070224283Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.Type: ApplicationFiled: April 11, 2007Publication date: September 27, 2007Applicant: ILYPSA, INC.Inventors: Han Chang, Dominique Charmot, Eric Connor, Florence Roger
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Publication number: 20060099169Abstract: Methods and compositions for the treatment of toxin-mediated diseases are provided herein. One aspect of the invention is oligosaccharide-based therapeutics that interact with toxins and methods of uses thereof. In one embodiment the oligosaccharide-based therapeutics of the invention comprise polymeric particles with attached oligosaccharide binding moieties. The compositions of the invention can be used in the treatment of toxin-mediated diseases such as antibiotic-associated diarrhea and pseudomembranous colitis, including Clostridium difficile associated diarrhea.Type: ApplicationFiled: October 13, 2005Publication date: May 11, 2006Applicant: Ilypsa, Inc.Inventors: Dominique Charmot, Jerry Buysse, Han Chang, Michael Cope, Tony Mong, Elizabeth Goka
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Publication number: 20050244367Abstract: The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.Type: ApplicationFiled: May 3, 2004Publication date: November 3, 2005Applicant: Ilypsa, Inc.Inventors: David Hui, Dominique Charmot, Jerry Buysse