Abstract: Disclosed is an intraluminal ultrasound imaging system, including a processor circuit in communication with an intraluminal ultrasound imaging catheter, and configured to receive a plurality of intraluminal ultrasound images from the imaging catheter during movement of the imaging catheter within a body lumen of a patient, the body lumen comprising a plurality of segments. The processor circuit is further configured to generate a marker to be applied to an intraluminal ultrasound image of the plurality of intraluminal ultrasound images, wherein the marker is generated based on the movement of the intraluminal ultrasound imaging catheter, and wherein the marker is representative of a segment of the plurality of segments, and output to a display the marker and the plurality of intraluminal ultrasound images shown successively.

Abstract: An apparatus for assessing the severity of stenosis in a blood vessel includes an elongate body including a distal portion and a centering assembly. The centering assembly is actuatable to selectively center the elongate body in the vessel. A pressure sensor is disposed adjacent the centering assembly and is configured to detect fluid pressure in the vessel. A processing system receives the measured pressure from the pressure sensor, receives data representing the cross-sectional area of the vessel, receives data representing the size of the distal portion, calculates a offset correlation based on the size of the distal portion and based on the size of the vessel, and calculates a fractional flow reserve (FFR) for the vessel as an index of stenosis severity taking into account the offset correlation and the measured fluid pressure from the pressure sensor.

Abstract: Disclosed is an intraluminal ultrasound imaging system, including a processor circuit in communication with an intraluminal ultrasound imaging catheter, and configured to receive a plurality of intraluminal ultrasound images obtained by the imaging catheter while the imaging catheter is moved through a body lumen of a patient. The processor circuit is further configured to determine a longitudinal translation speed of the imaging catheter based on the plurality of images and a known time interval between images, and display a speed indicator based on the longitudinal translation speed.

Abstract: Intravascular devices, systems, and methods are disclosed. In some embodiments, a medical imaging system for imaging vasculature of a patient is provided. The imaging system includes a console that has one or more processors with a medical imaging system interface running thereon, an acquisition card in communication with the one or more processors and in communication with a patient interface module (PIM), and an intravascular imaging component in communication with the PIM and disposed on a distal end of a flexible elongate member. The medical imaging system interface provides a plurality of settings groups for selection by a user, each of the settings groups having pre-acquisition parameters and post-acquisition parameters that are optimal for imaging a desired viewing target within the vasculature. Associated methods and computer-readable media are provided.

Abstract: A method of evaluating a vessel of a patient is provided. The method includes outputting, to a display device, a screen display including: a visualization based on pressure measurements obtained from a first instrument and a second instrument positioned within the vessel of the patient while the second instrument is moved longitudinally through the vessel and the first instrument remains stationary within the vessel; and a visual representation of a vessel; receiving a user input to modify the visualization to simulate a therapeutic procedure; and updating the screen display, in response to the user input, including modifying the visualization based on the user input. A system for evaluating a vessel of a patient is also provided. The system includes first and second instruments sized and shaped for introduction into the vessel of the patient; and a processing system communicatively coupled to the first and second instruments and a display device.

Abstract: An extension cable is adapted for use in an intravascular ultrasound system. It has a first connector, for connecting to a catheter and a second connector for connecting to a patient interface module. A cable arrangement provides power transmission, data transmission and data signal processing (amplification or regeneration) between the first and second connectors. The extension cable enables sterility to be maintained in a workflow in a time efficient and easy manner as the catheter to extension cable connection may remain in a sterile environment.

Abstract: An intravascular system includes at least one pressure-sensing instrument sized and shaped for introduction into a vessel of a patient; a processing unit in communication with the pressure-sensing instrument, the processing unit configured to: obtain proximal pressure measurements for at least one cardiac cycle of the patient while the pressure-sensing instrument is positioned proximal of a stenosis of the vessel; obtain distal pressure measurements while the pressure-sensing instrument is positioned distal of the stenosis; select a diagnostic window within a cardiac cycle by identifying a change in sign of a slope associated with the proximal and/or distal pressure measurements, wherein the diagnostic window encompasses only a portion of the cardiac cycle of the patient; calculate a pressure ratio between the distal and proximal obtained during the diagnostic window; and output the calculated pressure ratio to a display device in communication with the processing unit.

Abstract: Torque devices for use with intravascular devices and associated systems and methods are disclosed. In some embodiments, a torque device for use with an intravascular device includes a first component having a body defining a tapered opening for receiving a proximal portion of the intravascular device, a first arm extending from the body, and a second arm extending from the body; and a second component movably coupled to the first component, wherein the second component is movable relative to the first component between an open position where the torque device is configured to slidably receive the proximal portion of the flexible elongate member between the first and second arms of the first component and a closed position where the torque device fixedly engages the proximal portion of the flexible elongate member between first and second arms of the first component.

Abstract: Devices, systems, and methods for visually depicting a vessel and evaluating treatment options are disclosed. The methods can include introducing instruments into the vessel of a patient and obtaining proximal and distal pressure measurements of a stenosis of the vessel, calculating a pressure ratio based on the obtained proximal and distal pressure measurements, applying a correlation factor to the calculated pressure ratio to produce a predicted diagnostic pressure ratio, and displaying the predicted diagnostic pressure ratio to a user.

Abstract: Embodiments of the present disclosure are configured to assess effectiveness of an endovascular aneurysm coiling procedure. A system is provided that can include a flow-sensing intravascular device with a flexible elongate member which is sized and shaped for insertion into a vasculature, and a flow sensing element secured to a distal portion of the flexible elongate member. A computer can be in communication with the flow-sensing intravascular device. With a coil is positioned within an aneurysm, the computer can detect a flow measurement of fluid entering the aneurysm based on data obtained by the flow sensing element positioned within the aneurysm, and can determine that the fluid flow measurement is at or below an acceptable level. If flow is at an unacceptable level, additional coils can be added to further restrict flow. Also, a second source of fluid into the aneurysm can be indicated by the flow measurements.

Abstract: Systems, devices, and methods for providing procedure-specific workflow guidance are provided. The workflow guidance may include providing selectable options on a display device to a user including a selectable option to select a target vessel and a prompt to move an intravascular imaging device within the selected target vessel. Imaging data is received from the intravascular imaging device within the selected target vessel. The workflow guidance may be used to identify an area of interest within the selected target vessel and automatically display vessel measurements corresponding with the area of interest on the display device.

Abstract: Imaging devices, systems, and methods are provided. Some embodiments of the present disclosure are particularly directed to imaging a region of interest in tissue with photoacoustic and ultrasound modalities. In some embodiments, a medical sensing system includes one or more external optical emitters and a measurement apparatus configured to be placed within a vascular pathway. The measurement apparatus may include a sensor array comprising sensors of two or more types. The sensors may be configured to receive sound waves created by the interaction between emitted optical pulses and tissue, and transmit and receive ultrasound signals. The medical sensing system may also include a processing engine operable to produce images of the region of interest and a display configured to visually display the image of the region of interest.

Abstract: An imaging catheter is provided. In one embodiment, the imaging catheter includes a flexible elongate member that includes a proximal portion formed of a first material embedded with a first braid with a first braid pitch; a distal portion formed of a second material embedded with a second braid with a second braid pitch, wherein the second material is a lower durometer than the first material and wherein the second braid pitch is a higher per inch count than the first braid pitch such that the distal portion is more flexible than the proximal portion; a primary lumen extending between the proximal portion and the distal portion; and a plurality of secondary lumens extending between the proximal portion and the distal portion; and an imaging component coupled to the distal portion of the flexible elongate member.

Abstract: Improved ultrasound imaging devices and methods of using the devices are provided. An intraluminal imaging device is configured process imaging data obtained using a single imaging sequence in different processing paths to generate B-mode and flow images. For example, an ultrasound imaging system includes an ultrasound imaging device comprising an array of acoustic elements and a processor in communication with the array. The processor activates the array of acoustic elements to acquire ultrasound data using a sequence of transmit-receive pairs, generates a B-mode image using the acquired ultrasound data, forms a plurality of sub-apertures comprising a portion of the transmit-receive pairs, groups the sub-apertures into temporally-spaced ensembles, determines a flow estimate based on a comparison of at least one of sub-apertures within an ensemble, ensembles within an aperture, or different apertures, and outputs a graphical representation of the B-mode image and the flow estimate to a display.

Abstract: A wireless intraluminal imaging device and an associated system are provided. In one embodiment, the wireless intraluminal imaging device includes a flexible elongate member including a proximal portion and a distal portion; an ultrasound imaging component coupled to the distal portion of the flexible elongate member; a cable coupled to the ultrasound imaging component and extending along the flexible elongate member; and a wireless communication component coupled to the proximal portion of the flexible elongate member, the wireless communication component in communication with the ultrasound imaging component via the cable. The wireless communication component wirelessly transmits ultrasound echo signals collected by the ultrasound imaging component to an image processing system via a wireless link for image generation at the image processing component.

Abstract: An intraluminal imaging device includes a flexible elongate member configured to be inserted into a lumen within a body of a patient, the flexible elongate member comprising a longitudinal axis; an imaging assembly coupled to the flexible elongate member, the imaging assembly comprising: a plurality of ultrasound transducer elements disposed around the longitudinal axis of the flexible elongate member; a plurality of controllers configured to control the plurality of ultrasound transducer elements to obtain imaging data associated with the lumen; and a plurality of electrical wires extending between the plurality of the ultrasound transducer elements and the plurality of controllers and configured to facilitate communication between the plurality of the ultrasound transducer elements and the plurality of controllers.

Abstract: A method for imaging a volume within a patient volume is provided. The method includes generating a first signal and a second signal, directing the first signal and the second signal to a spot in the patient volume; receiving a first response signal and a second response signal from the spot in the patient volume; providing a first image from of the patient volume using the first response signal; providing a second image from the patient volume using the second response signal; and combining the first image and the second image to form a composite image. The method includes receiving multiple images at multiple frequency ranges; selecting a region of interest including the plurality of images; selecting multiple border lines separating the region of interest into multiple sub-regions; selecting data from an image in a sub-region; and forming an image in the region of interest.

Abstract: Imaging devices, systems, and methods are provided. Some embodiments of the present disclosure are particularly directed to imaging a region of interest in tissue with photoacoustic and ultrasound modalities. In some embodiments, a medical sensing system includes one or more external optical emitters and a measurement apparatus configured to be placed within a vascular pathway. The one or more optical emitters and the measurement apparatus may be moved together synchronously. The measurement apparatus may be configured to receive sound waves created by the interaction between emitted optical pulses and tissue, and transmit and receive ultrasound signals. The medical sensing system may also include a processing engine operable to produce images of the region of interest and a display configured to visually display the image of the region of interest.

Abstract: Disclosed is an intraluminal ultrasound imaging system, including a processor circuit in communication with an intraluminal ultrasound imaging catheter, wherein the processor circuit is configured to receive a plurality of intraluminal ultrasound images obtained by the intraluminal ultrasound imaging catheter during movement of the intraluminal ultrasound imaging catheter within a body lumen of a patient. The processor circuit is further configured to select an image from among the plurality of intraluminal ultrasound images, generate at least two border contours associated with the lumen within the selected image, display the border contours associated with the lumen, each overlaid on a separate instance of the selected image, receive a user input selecting one of the border contours; and display the selected image overlaid with the selected border contour.

Abstract: Intraluminal ultrasound imaging device, systems and methods (e.g., method of fabricating the device) are provided. In some embodiments, the intraluminal ultrasound imaging device includes a flexible elongate member configured to be positioned within a body lumen of a patient, and an ultrasound scanner assembly disposed at a distal portion of the flexible elongate member and configured to obtain imaging data of the body lumen. The ultrasound scanner assembly includes a flexible substrate, a first under-bump metallization (UBM) layer over the flexible substrate, a first solder feature over the first UBM layer, and a first electronic component electrically connected to the first solder feature.