Abstract: A method and apparatus extract a signal component of a measured signal using one of two methods. If the signal component in the measured signal is a periodic signal with a certain well-defined peak-to-peak intensity value, upper and lower envelopes of the measured signal are determined and analyzed to extract said signal component of the measured signal. This signal component can further be used to calculate a desired parameter of the sample. The DC component of the signal is determined as the median value of the upper envelope, and the AC component is determined as the median value of the difference between the upper and lower envelopes. If the signal component of the measured signal is a periodic signal characterized by a specific asymmetric shape, a specific adaptive filtering is applied to the measured signal, resulting in the enhancement of the signal component relative to a noise component.

Abstract: A biopsy device is provided which includes a localization needle having a guide wire preloaded into the biopsy device. The device includes a stylet having a blade for transecting and separating tissue. The device further includes a cannula for cutting a core of tissue and a garrote wire mechanism for cutting a transection of tissue transverse to the core cut by the cannula. The garrote wire is activated by a trigger mechanism which is locked out by a lockout feature within the device until the garrote wire has been advanced around the core of tissue cut by the cannula.

Abstract: A method and apparatus extract a signal component of a measured signal using one of two methods. If the signal component in the measured signal is a periodic signal with a certain well-defined peak-to-peak intensity value, upper and lower envelopes of the measured signal are determined and analyzed to extract said signal component of the measured signal. This signal component can further be used to calculate a desired parameter of the sample. The DC component of the signal is determined as the median value of the upper envelope, and the AC component is determined as the median value of the difference between the upper and lower envelopes. If the signal component of the measured signal is a periodic signal characterized by a specific asymmetric shape, a specific adaptive filtering is applied to the measured signal, resulting in the enhancement of the signal component relative to a noise component.

Abstract: Disclosed is a brachytherapy seed deployment system, for use in any of a variety of medical procedures such as radiation treatment of the prostate gland. The system includes a number of brachytherapy seed deployment needles, each preloaded with brachytherapy seeds in patterns and activities predetermined for a unique patient. The seeds are contained in transparent tubular sleeves, thereby allowing direct visualization of the brachytherapy seeds and spacers, so that the seed pattern may be inspected at the clinical site. A releasable retainer prevents accidental brachytherapy seed loss. The system additionally includes shipping containers, separately accessible calibration seeds and a display stand for use at the clinical site. Methods are also disclosed.

Abstract: A biopsy device is provided which includes a localization needle having a guide wire preloaded into the biopsy device. The device includes a stylet having a blade for transecting and separating tissue. The device further includes a cannula for cutting a core of tissue and a garrote wire mechanism for cutting a transection of tissue transverse to the core cut by the cannula. The garrote wire is activated by a trigger mechanism which is locked out by a lockout feature within the device until the garrote wire has been advanced around the core of tissue cut by the cannula.

Abstract: A surgical clip applier for application of surgical clips to body tissue is disclosed. The clip applier includes an elongated housing having proximate and distal ends. This housing also defines a feed surface for the surgical clips. The clip applier also includes first and second jaws extending from the distal end of the housing. The jaws open and close to apply the surgical clips to the body tissue of the patient. A driver is disposed within the housing to advance the surgical clips from the feed surface to the jaws. The clip applier of the present invention incorporates a backing surface extending from the distal end of the housing and extending along the jaws. Accordingly, the backing surface bears against the jaws by constantly applying a force such that the housing is always pre-loaded against the jaws. As such, the jaws are maintained in proper alignment with the feed surface and the surgical clips can be advanced from the feed surface to the jaws without a misfeed.

Abstract: Apparatus and methods are provided for monitoring cardiac output using bioelectrical impedance techniques in which three orthogonal pairs of sense electrodes are placed in the trachea or esophagus in the vicinity of the aorta, while an excitation current is injected into the intervening tissue mass via a current electrode, so that bioelectrical impedance measurements based on the voltage drop sensed by the sense electrodes reflect voltage changes induced primarily by blood flow dynamics. Methods are provided for computing cardiac output from bioelectrical impedance values using a multi-parameter algorithm derived using stepwise multiple linear regression or other optimization techniques. Apparatus and methods are also provided so that the measured cardiac output may be used to control administration of intravenous fluids or medication to an organism or to optimize a heart rate controlled by a pacemaker.

Abstract: A breast biopsy device is provided which includes a localization needle having a guide wire preloaded into the biopsy device. The device includes a stylet having a blade for transecting and separating healthy tissue on route to the biopsy site. The use of the stylet blade reduces the trauma to healthy breast tissue. The device further includes a cannula blade and a garrote for forming a cut transverse to the core cut by the cannula blade. A lockout feature prevents the garrote from deploying until after a cutting plane of the garrote has been advanced beyond the end of the guide wire.

Abstract: A trocar seal system is provided which permits surgical instruments of at least two different diameters to use the same cannula of a trocar while maintaining a sealed body cavity. The seal system mounts to a cannula of the trocar. The seal system includes an upper seal and a lower seal with the upper seal having a larger opening than the lower seal. The lower seal is mounted on a pivotal hinge plate which permits the lower seal to be moved out of the way when a larger diameter surgical instrument is inserted through the upper seal. When a smaller diameter surgical instrument is inserted through the upper seal, the lower seal is not moved out of its path and the lower seal seals about the smaller diameter surgical instrument.

Abstract: A breast biopsy device is provided which includes a localization needle having a guide wire preloaded into the biopsy device. The device includes a stylet having a blade for transecting and separating healthy tissue on route to the biopsy site. The use of the stylet blade reduces the trauma to healthy breast tissue. The device further includes a cannula blade and a garrote for forming a cut transverse to the core cut by the cannula blade. A lockout feature prevents the garrote from deploying until after a cutting plane of the garrote has been advanced beyond the end of the guide wire.

Abstract: Objective lenses for endoscopes are made substantially of sapphire. The high refractive index of sapphire results in optical components with shallower curvatures, leading to smaller geometric aberrations, and consequently, fewer components are required to correct for these aberrations. Chromatic aberrations are less severe because of sapphire's low dispersion. The objectives may be either of the landscape or retrofocus type, and are compact with moderate field of view, low f-number, and less distortion than most conventional designs.

Abstract: This invention provides a linear stapling instrument for use in surgical procedures including, inter alia, a staple housing. The housing includes a plurality of staple openings and a plurality of staples disposed in the staple openings. The housing further includes a plurality of staple drivers. The staple drivers have an upper surface bearing on a staple and a lower camming surface. The staple drivers are slidably mounted in the housing for movement from an initial lower position to an upper position. They also are arranged such that their lower camming surfaces are disposed in one or more spaced rows. The housing also includes a sled slidably mounted in the housing for movement from an unfired position to a fired position. The sled has at least one camming surface. The camming surface is disposed on the sled such that movement of the sled from its unfired to its fired position causes the camming surface to contact in sequence the lower camming surface of the staple drivers in at least one the row.

Abstract: A medical device for deploying surgical fabric at an operative site within a body cavity of a patient. The device includes a deploying member in the form of an elongated inserter shaft with a supporting member in the form of a sheet of plastic attached to a distal end of the shaft. A sheet of surgical fabric is placed on the supporting member and rolled around the inserter shaft. An introducer tube surrounds the rolled-up fabric and supporting member to prevent them from unrolling. The introducer tube may then be inserted into the body cavity and retracted to allow the supporting member to self-unwind the fabric sheet within the body cavity. The device may also provide for irrigation of the surgical site.

Abstract: A trocar for use in surgical procedures including a cannula for maintaining a sealed working channel in a body wall and an obturator which creates the working channel through the body wall while protecting patients and medical personnel from harm is disclosed. A cannula converter which can be employed with the trocar to enable a surgeon to use surgical instruments having a smaller outer diameter than the inner diameter of the cannula without deflating a body cavity is further disclosed. A site stabilizer which can be used with the trocar to prevent the cannula from being inadvertently withdrawn from the body cavity during a surgical procedure is also disclosed.

Abstract: An intubation device comprises an imaging conduit including an illumination conduit for delivering illumination to a distal end of the device and an image-receiving conduit for communicating images from the distal end of the device to the proximal end of the device. The device also comprises a flushing conduit for delivery of fluids and/or gases to the distal end of the device. The image conduit and the flushing conduit are attached at the distal end of the device. The distal end of the device can be manipulated by advancing the imaging conduit in an axial direction while maintaining the flushing conduit fixed in place. Furthermore, a length adjustment member is provided for adjusting the extent to which the distal end of the device extends beyond a distal end of an endotracheal tube which is inserted over the imaging and flushing conduits. The illuminating conduit and the image-receiving conduit terminate in separate ports at the distal end of the device.

Abstract: An introducer is shown and described which includes a number of unique and useful features designed to improve the process of obtaining access to a bodily cavity for the purpose of performing minimally invasive surgical procedures, particularly laparoscopic procedures. These features include, among others, a sharpened cannula distal end, in order to assist entry of the introducer through the tissue barrier into the bodily cavity, a substantially transparent support disk so that visual access to the insertion site is maintained at all times, a septum seal designed to sealingly receive instruments having a cross-sectional dimension of 2.2 mm or less, an improved anchoring device which is simply and manually actuated and is of an advantageous three-slit design, and a simple, side-mounted gas insufflation port, usable at all times during the procedure and adapted for connection to gas tubing fitted with a pinch clamp for easy control of the gas flow.

Abstract: Apparatus and methods are provided for monitoring cardiac output using bioelectrical impedance techniques in which first and second electrodes are placed in the trachea and/or bronchus in the vicinity of the ascending aorta, while a sense current is injected into the thorax via first and second source electrodes, so that the resulting bioelectrical impedance measurements reflect voltage changes induced primarily by blood flow dynamics, rather than respiratory or noncardiac related physiological effects. Apparatus and methods are also provided so that the measured cardiac output may be used to control administration of intravenous fluids to a patient or to optimize heart rate for those patients having pacemakers.