Abstract: A sensing microsystem that can be used to sense various physiological parameters of a subject is disclosed. The sensing microsystem comprises one or more sensors for collecting data that can be used to accurately determine various vital sign and/or other physiological parameters of the subject, and further comprises a communication module that allows the microsystem to communicate remotely with an external device via one or more communications protocols. The one or more sensors and the communication module are disposed on respective electronics-compatible substrates that are electrically coupled with a power source. An isolated communication channel that communicatively couples the one or more sensors and the communication interface is at least partially defined by and extends through the power source.