Patents Assigned to Imedex
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Patent number: 6730299Abstract: A biocompatible fluid adhesive protein foam, which is bioresorbable and nontoxic, for surgical and/or therapeutic use, in particular for protecting/cicatrizing tissue wounds and for attaching biological tissues to each other or to an implanted biomaterial. The biocompatible fluid adhesive protein foam includes a biocompatible fluid adhesive protein matrix, which is bioresorbable and nontoxic, containing a biocompatible and nontoxic gas or mixture of gases. Further, a process and a kit for preparing such a foam are provided.Type: GrantFiled: March 20, 2001Date of Patent: May 4, 2004Assignee: Imedex BiomateriauxInventors: Jean-Louis Tayot, Yves Bayon, Philippe Gravagna, Michel Marie Dubois
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Patent number: 6706684Abstract: The invention concerns a method for preparing a non-toxic, sterile, biocompatible, crosslinked collagen material with controlled in vivo biodegradation speed. It consists in subjecting a collagen constituent, either to beta radiation, or to gamma radiation. The collagen material obtained is biodegradable in a few days depending on the type of irradiation used.Type: GrantFiled: May 29, 2001Date of Patent: March 16, 2004Assignee: Imedex BiomateriauxInventors: Yves Bayon, Philippe Gravagna, Jean-Louis Tayot
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Patent number: 6605066Abstract: A device for the formation and delivery of a mixture, notably a surgical adhesive, consisting of a receptacle adapted for easy handling by the surgeon, and including the means of receiving two syringe barrels containing the constituents of the mixture, the means of simultaneously expelling the contents, the means of maintaining the contents of syringe containing the first constituent, at a predetermined temperature setting which is higher than body temperature, and a mixer simultaneously receiving the contents of the two syringes, and the mixer also being used for cooling.Type: GrantFiled: August 29, 2000Date of Patent: August 12, 2003Assignee: Imedex BiomateriauxInventors: Philippe Gravagna, Jean-Louis Tayot
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Method for preparing two-layer bicomposite collagen material for preventing post-operative adhesions
Patent number: 6596304Abstract: A bicomposite material based on collagen is prepared which has two closely bound layers and is biocompatible, non-toxic, hemostatic and biodegradable in less than a month, and can be used in surgery to achieve hemostasis and prevent post-surgical adhesion. To prepare the material, a solution of collagen or gelatin, which may contain glycerine and a hydrophilic additive such as polyethylene glycol or a polysaccharide, is poured onto an inert support to form a layer 30 &mgr;m to less than 100 &mgr;m thick. Then a polymeric porous fibrous layer is applied during gelling of the collagen or gelatin, and the resultant material is dried. The polymeric porous fibrous layer may be made of collagen or a polysaccharide, and have a density of not more than 75 mg/cm2, a pore size from 30 &mgr;m to 300 &mgr;m and a thickness of 0.2 cm to 1.5 cm.Type: GrantFiled: July 11, 2000Date of Patent: July 22, 2003Assignee: Imedex BiomateriauxInventors: Yves Bayon, Philippe Gravagna, Jean-Lois Tayot -
Patent number: 6451032Abstract: The composite prosthesis comprises a prosthetic fabric having a three-dimensional structure separating two surfaces, one of which is open to post-surgical cell colonization. The composite prosthesis further comprises at least one film of a collagenous material linked to the other surface of the prosthetic fabric. The composite prosthesis may be used to prevent post-surgical adhesion.Type: GrantFiled: January 24, 2000Date of Patent: September 17, 2002Assignees: Sofradim Production, Imedex BiomateriauxInventors: François Régis Ory, Michel Therin, Philippe Gravagna, Jean-Louis Tayot
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Patent number: 6391939Abstract: The present invention relates to a biocompatible collagenous material which is non-toxic and biodegradable in less than one month, preferably in less than one week. This material comprises collagen and at least one hydrophilic macromolecular additive which is chemically non-reactive towards the collagen, with the collagen having at least partially lost its helical structure and being crosslinked. The invention also relates to a process for obtaining such a material. The collagenous material according to the invention is used, in particular, for preventing post-operative adhesions.Type: GrantFiled: August 5, 1999Date of Patent: May 21, 2002Assignee: Imedex BiomateriauxInventors: Jean-Louis Tayot, Michel Tardy, Philippe Gravagna
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Patent number: 5654135Abstract: Biomaterial based on collagen comprises, intimately associated, a support forming a dermal substitute, said support comprising a layer based on type IV collagen and an epidermal epithelium having differentiated cells obtained by growing epidermal cells on said support.Type: GrantFiled: June 19, 1995Date of Patent: August 5, 1997Assignees: Imedex, societe anonyme, Pasteur Merieux Serums et Vaccins, societe anonymeInventors: Estelle Tinois, Jerome Tiollier, Henri Dumas, Michel Tardy
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Patent number: 5654290Abstract: Drug compositions comprised of therapeutically effective amounts of at least one compound selected from the group consisting of:DHA esterified in the form of lysophosphatidyl-choline (lyso-PCDHA) in position sn-2;DHA-phosphatidylcholines (PCDHAs) in which DHA is esterified in position sn-2 and which have an acyl group of [very short length] 2 to 6 carbon atoms in position sn-1;and triglycerides in which DHA is esterified in position sn-2 and which have acyl groups of [very short length] 2 to 6 carbon atoms in positions sn-1 and sn-3.Type: GrantFiled: September 21, 1994Date of Patent: August 5, 1997Assignees: Institut National de la Sante et de la Recherche Medicale, ImedexInventors: Yves Bayon, Martine Croset, Michel Lagarde, Jean Lecerf, Frank Thies, Jean-Louis Tayot, Veronique Chirouze
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Patent number: 5618551Abstract: The invention relates to a biocompatible, bioresorbable and non-toxic adhesive composition for surgical use, for the bonding, in particular, of biological tissues to one another or in an implanted biomaterial, characterized in that it comprises a reactive acidic solution of non-crosslinked and potentially crosslinkable collagen or gelatin modified by oxidative cleavage, at a concentration which is preferably between approximately 5 and 30 by weight. It also relates to reactive acidic solutions and powders based on non-crosslinked collagen or gelatin modified by oxidative cleavage which are used as intermediate products in the preparation of the above-mentioned composition, and to the process for their preparation. It also relates to adhesive kits which comprise, on the one hand, the above-mentioned reactive acidic solution and, on the other hand, a neutralizing solution and which are intended for extemporaneous mixing.Type: GrantFiled: January 20, 1995Date of Patent: April 8, 1997Assignee: ImedexInventors: Michel Tardy, J er ome Tiollier, Jean-Louis Tayot
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Patent number: 5496872Abstract: The invention relates to an adhesive, biocompatible, biodegradable and non-toxic composition for surgical use, in particular for binding tissues, which composition is of the following general formula: ##STR1## in which: R is a hydrocarbon chain containing from 1 to 50 carbon atoms,R.sub.1 and R.sub.2 are identical or different and are chosen from the following groups: ##STR2## R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.Type: GrantFiled: July 19, 1994Date of Patent: March 5, 1996Assignee: ImedexInventors: Alain Constancis, Ge/ rard Soula, Jean-Louis Tayot, Je/ ro/ me Tiollier
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Patent number: 5436135Abstract: Human or animal placenta is subjected to moderate enzymatic digestion, in particular with pepsin at an acid pH, then, after separation of the residual tissue the impurities are separated at a moderately acid pH, the collagen is precipitated at a neutral pH, redissolved and the residual impurities precipitated at an acid pH. The collagen obtained can be brought back to a neutral pH and dried in the form of fibres. Completely transparent, physiological and hemocompatible gels and solutions can be prepared. Applications for the fabrication of contact lenses and implants.Type: GrantFiled: January 7, 1991Date of Patent: July 25, 1995Assignees: Pasteur Merieux Serums et Vaccins, ImedexInventors: Jean-Louis Tayot, Michel Tardy
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Patent number: 5201745Abstract: A patch for visceral surgery is made from a biomaterial consisting of two layers of collagen superimposed and closely combined, namely a porous adhesive layer of fibrous collagen and a film of collagen and/or gelatin.Type: GrantFiled: August 15, 1991Date of Patent: April 13, 1993Assignee: ImedexInventors: Jean-Louis Tayot, Jacques Marescaux, Henri Dumas, Michel Tardy
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Patent number: 5108908Abstract: A process for pigments such as the treatment of proteinic solutions containing heminic groups or chlorophylls in view of their decolorization, and products thus obtained.The proteinic solution is subjected in a first step, to a slight enzymatic hydrolysis, preferably with acid pH pepsin, and the partially hydrolyzed solution is then brought to a temperature above 60.degree. C., at an acid pH between 2 and 4.Type: GrantFiled: September 14, 1990Date of Patent: April 28, 1992Assignees: Imedex, DibevialInventors: Jacques Coves, Jean-Louis Tayot
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Patent number: 4931546Abstract: Collagen is submitted to a controlled oxidation by treatment with a solution of periodic acid or of a periodate, notably of sodium. Application to gels, implants, lenses, films, spheres, etc., of collagen.Type: GrantFiled: July 13, 1987Date of Patent: June 5, 1990Assignees: Imedex, Institut MerieuxInventors: Michel Tardy, Jean-Louis Tayot
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Method for preparing two-layer bicomposite collagen material for preventing post-operative adhesions
Patent number: RE39172Abstract: A bicomposite material based on collagen is prepared which has two closely bound layers and is biocompatible, non-toxic, hemostatic and biodegradable in less than a month, and can be used in surgery to achieve hemostasis and prevent post-surgical adhesion. To prepare the material, a solution of collagen or gelatin, which may contain glycerine and a hydrophilic additive such as polyethylene glycol or a polysaccharide, is poured onto an inert support to form a layer 30 ?m to less than 100 ?m thick. Then a polymeric porous fibrous layer is applied during gelling of the collagen or gelatin, and the resultant material is dried. The polymeric porous fibrous layer may be made of collagen or a polysaccharide, and have a density of not more than 75 mg/cm2, a pore size from 30 ?m to 300 ?m and a thickness of 0.2 cm to 1.5 cm.Type: GrantFiled: September 16, 1999Date of Patent: July 11, 2006Assignee: Imedex BiomateriauxInventors: Yves Bayon, Philippe Gravagna, Jean-Louis Tayot