Abstract: Provided is a composition comprising sonosensitive liposomes for penetrating the blood-brain barrier, wherein the sonosensitive liposomes have excellent drug loading efficiency and ultrasound-induced drug release effect and can effectively penetrating the blood-brain barrier during ultrasound stimulation, and the sonosensitive liposomes can circulate in the body for a long time, and thus have better blood-brain barrier penetration efficiency, a high affinity for brain tumor cells, and excellent delivery effect to tumor sites and can be used as a drug delivery system for delivering brain disease therapeutic agents and the like to the brain.

Abstract: Disclosed are an ultrasound imaging apparatus for brain disease treatment and an ultrasound imaging and treatment method using same. The ultrasound imaging apparatus for brain disease treatment according to an embodiment includes an image obtainment unit which obtains a medical image of the brain of a patient captured before a procedure; a transducer unit which transmits an ultrasound signal for imaging and ultrasound focusing of the brain of the patient; an image generation unit which generates an ultrasound image on the basis of the ultrasound signal received from the brain; a position alignment unit which controls a position of the transducer unit to align a position of the generated ultrasound image with a position of the obtained medical image; an image matching unit which matches two images of which positions are aligned; and an image display unit which detects and displays a brain lesion by using a matched image.

Abstract: Disclosed are a focused ultrasound device and an image transducer protection method. The focused ultrasound device according to an embodiment comprises: an ultrasound probe structure including a treatment transducer for transmitting a focused ultrasound signal and an image transducer for transmitting and receiving an ultrasonic image signal; a reception switch for selecting a plurality of first elements among elements of the image transducer as protection areas and deactivating same, and selecting a plurality of second other elements among the elements of the image transducer as reception areas and activating same; an image beamformer for forming a reception beam signal by focusing ultrasonic echo signals received from the plurality of second elements; an image generation unit for generating an image for a target area in an object on the basis of the reception beam signal; and a control unit for controlling the selection of the protection areas and reception areas by means of a reception switch.

Abstract: Disclosed are a focused ultrasound device and a method for setting an order of focused ultrasound treatment thereof. When using an ultrasound treatment method using mechanical energy, the focused ultrasound device according to an embodiment determines a next focal point position in consideration of at least one previous focal point position of focused ultrasound and thus can minimize thermal increase of an affected area and maximally utilize the mechanical energy.

Abstract: The present invention relates to novel nanoparticles using an anionic polymer, a preparation method thereof, a composition, and the like, and the present invention is used for a method of necrosing cancer cells by blocking major blood vessels that supply nutrients to cancer cells to induce an embolic effect, and thus may be used for the treatment of patients with cancer.

Abstract: An ultrasound treatment head and an ultrasound imaging and treatment method using the same are disclosed. The ultrasound treatment head according to an embodiment comprises: a structure including a treatment transducer and an imaging probe positioned at the center of the treatment transducer, the treatment transducer and the imaging probe being physically aligned; a first mechanism for steering the mechanical movement of the entire structure; and a second mechanism for steering the mechanical movement of either the imaging probe or the treatment transducer alone in the structure.

Abstract: The present invention aims to dramatically increase the effect of hepatic arterial chemoembolization by developing human serum albumin-based nanoparticles, which are bioproteins that effectively carry Adriamycin in place of Adriamycin, an anticancer agent used in hepatic arterial chemoembolization. The human serum albumin nanoparticles carrying the Adriamycin not only intensively infiltrate the drug effectively into the cells but also have a synergistic effect that can induce a long-term therapeutic effect by utilizing the effect of continuous drug release from the particles.

Abstract: Provided is an immune microbubble complex, and a use thereof. An immune-microbubble complex (IMC) according to the presently claimed subject matter includes microbubbles to which an antibody is conjugated, in which the microbubbles have excellent stability and excellent antibody binding strength, and it was confirmed that, when the immune-microbubble complex is treated with high-intensity focused ultrasound (HIFU), an anti-tumor effect is significantly increased and an immune-enhancing effect is exhibited. Therefore, the immune-microbubble complex according to the presently claimed subject matter is expected to increase the efficiency of delivering the conjugated antibody and be used in both diagnosis and treatment of cancer, and exhibit various functions in the field of immunotherapy, including a contrast effect, half-life improvement, improved drug delivery, a lymphocyte concentration effect, cancer immunotherapy and induction of immunotherapy using ultrasound.

Abstract: The present invention provides a dual-purpose photoacoustic tomography (PAT)/ultrasound contrast agent comprising: (a) a micro-bubble containing gas and porphyrin therein; and (b) nanoparticles bound on a surface of the micro-bubble and containing a drug. The contrast agent of the present invention can be used in both the ultrasound diagnosis and the photoacoustic image diagnosis, and can significantly increase the accuracy of photoacoustic images.

Abstract: The present invention aims to dramatically increase the effect of hepatic arterial chemoembolization by developing human serum albumin-based nanoparticles, which are bioproteins that effectively carry Adriamycin in place of Adriamycin, an anticancer agent used in hepatic arterial chemoembolization. The human serum albumin nanoparticles carrying the Adriamycin not only intensively infiltrate the drug effectively into the cells but also have a synergistic effect that can induce a long-term therapeutic effect by utilizing the effect of continuous drug release from the particles.

Abstract: The present invention provides a dual-purpose photoacoustic tomography (PAT)/ultrasound contrast agent comprising: (a) a micro-bubble containing gas and porphyrin therein; and (b) nanoparticles bound on a surface of the micro-bubble and containing a drug. The contrast agent of the present invention can be used in both the ultrasound diagnosis and the photoacoustic image diagnosis, and can significantly increase the accuracy of photoacoustic images.