Abstract: The invention relates to the treatment of cancer. In one embodiment, the present invention provides a composition comprising a micelle construct attached to a curcumin molecule or a pharmaceutical equivalent, analog, derivative, or salt thereof, and a chemotherapy agent. In another embodiment, the present invention provides a method of treating cancer by administering a therapeutically effective amount of a composition comprising a micelle construct attached to curcumin or a pharmaceutical equivalent, analog, derivative, or salt thereof, and a chemotherapy agent.

Abstract: Disclosed herein are compositions and nanoconjugates comprising a micelle construct; an antibody single chain fragment variable (scFv); a NF-kb inhibitor; and a topoisomerase II inhibitor. Further disclosed herein are methods of delivering a drug molecule to a tumor site of a subject comprising: attaching the drug molecule to a targeted micelle, wherein the targeted micelle comprises a micelle construct and an antibody single chain fragment variable (scFv); and delivering the drug molecule attached to the targeted micelle to the tumor site through intracellular delivery. Also disclosed herein are methods of treating cancer or inhibiting tumor cell growth comprising administering to a subject in need thereof, a therapeutically effective dosage of a composition comprising a micelle construct, an antibody single chain fragment variable (say), a NF-kb inhibitor, and a topoisomerase II inhibitor.

Abstract: Disclosed herein are methods of treating pancreatic cancer and/or multiple myeloma cancer in a subject, comprising: providing a composition comprising a micelle construct attached to curcumin; and treating pancreatic cancer and/or multiple myeloma cancer in the subject by administering a therapeutically effective dosage of the composition to the subject. Further disclosed herein are pharmaceutical compositions, comprising: an inhibitor of NF-kB; a glut-1 antibody; and a pharmaceutically acceptable carrier. Also disclosed herein are methods of using the same.

Abstract: The invention relates to the treatment of cancer. In one embodiment, the present invention provides a composition comprising a micelle construct attached to a glut-1 antibody and a curcumin molecule. In another embodiment, the present invention provides a method of treating colon and/or breast cancer by administering a therapeutically effective amount of composition comprising a targeted construct attached to an inhibitor of NF-kB.

Abstract: Disclosed herein are compositions and nanoconjugates comprising a micelle construct; an antibody single chain fragment variable (scFv); a NF-kb inhibitor; and a topoisomerase II inhibitor. Further disclosed herein are methods of delivering a drug molecule to a tumor site of a subject comprising: attaching the drug molecule to a targeted micelle, wherein the targeted micelle comprises a micelle construct and an antibody single chain fragment variable (scFv); and delivering the drug molecule attached to the targeted micelle to the tumor site through intracellular delivery. Also disclosed herein are methods of treating cancer or inhibiting tumor cell growth comprising administering to a subject in need thereof, a therapeutically effective dosage of a composition comprising a micelle construct, an antibody single chain fragment variable (scFv), a NF-kb inhibitor, and a topoisomerase II inhibitor.

Abstract: The invention relates to the treatment of cancer. In one embodiment, the present invention provides a composition comprising a micelle construct attached to a glut-1 antibody and a curcumin molecule. In another embodiment, the present invention provides a method of treating colon and/or breast cancer by administering a therapeutically effective amount of composition comprising a targeted construct attached to an inhibitor of NF-kB.

Abstract: A millable, vulcanizable elastomeric composition comprising two fluoroelastomer phases, phase 1 and phase 2, wherein fluoroelastomer phase 1 is present as crosslinked fluoroelastomer particles, and where fluoroelastomer phase 2 remains flowable until a final stage vulcanization occurs, and where fluoroelastomer phase 1 is present at between 5-85% by weight of the final composition.

Abstract: An automated prefix dialing system is disclosed to allow a subscriber/user to automatically insert a predetermined prefix dialing code in certain outgoing telephone call situations. The system is electrically disposed between the telephone company's central office circuit and the subscriber's circuit. The system preferably comprises six sub-circuits: DC power path circuit (off-hook sensor circuit), shadow-ring detector circuit, isolation circuit, DTMF receiver circuit, DTMF generator circuit, and micro controller circuit. When not in use, no power is used by the system. The DC power path circuit, provides power received from the central office line to the various circuits and components of the system when the subscriber's phone is taken off-hook. Off-hook sensor circuitry detects when the telephone has been lifted either in response to an incoming call or to initiate an outgoing call.

Abstract: A moldable, extrudable, thermally crosslinkable composition of matter containing 50-99% by weight fluoropolymers, in which 50-95% of the polymer content of the blend is an FKM fluoroelastomer and 5-50% of the polymer content of the blend is one or more thermoplastic PVDF polymers or copolymers containing at least 70% by weight vinylidene fluoride monomer units, and the crosslinked articles derived from processing and curing the subject composition of matter.

Abstract: The invention involves a means of increasing the scorch delay period (scorch time) for standard bisphnol-cured fluoroelastomers (abbreviated as “FKM;” these are copolymers of vinylidene fluoride and hexafluoropropene, optionally also containing additional monomers such as tetrafluoroethylene). The invention entails particular subtituted monophenols (butylparaben or propylparaben) and/or mixtures of these with methylparaben and/or inorganic solids, and the inclusion of these particular substituted monophenols and/or blends in an FKM compound. These particular substituted monophenols are effective as scorch inhibitors of bisphenol-cured FKM, and are also effective as processing aid.

Abstract: A combination utensil tool with attachable utensils, such as forks, spoons, and knives which are easy to attach and detach from a common handle. The present invention comprises a built up contoured handle preferably having a raised rim on a first end and a downward extending lip on a second end. Attached to the first end of the handle is a shaft having a roller knife (or other type of knife) attached thereto. The roller knife enables the user to cut food with the use of one hand. Attached to the second end of the handle is either a spoon, fork or knife (collectively known as a utensil). The utensil comprises a shaft having a head and a notch. The shafts of the utensils are either straight or have an upward or downward angled bend in order to allow the user to eat with minimal wrist movement. The utensil is firmly coupled to the second end of the handle by a spring loaded release mechanism comprising a rod having a downward projection which permits the user to attach and detach several utensil to the handle.

Abstract: A method and system for combining digital data signals representing digitized images to implement a DSK operation in one mixing stage. The system requires only one mixing circuit, rather than two as in conventional DSK systems. In preferred embodiments, the DSK operation processes an input video signal having pixels a.sub.k, an input video signal having pixels b.sub.k, a stream of single-color pixels B, and a fade control signal .beta., to generate a stream of output pixels u.sub.k =(1-.beta.)v.sub.k +.beta.B, where v.sub.k =(1-.alpha.)a.sub.k +(.alpha.)b.sub.k, and .alpha. is a key signal which can have a different value for each pixel a.sub.k. The value of .alpha. can be constant for an entire frame of input pixels a.sub.k or can have a different value for each individual pixel a.sub.k. Typically, the value of .beta. is constant for each frame of input pixels a.sub.k. Preferred embodiments of the system employ a single mixing circuit, which receives five input data streams: first pixels a.sub.

Abstract: A method and apparatus for transforming image data by recursively interleaving the data to generate blocks of component image coefficients having form suitable for subsequent quantization, motion estimation, and/or coding. In preferred embodiments, the transformed data are in optimal form for coding by conventional circuitry in accordance with the conventional JPEG or MPEG compression algorithm. In preferred embodiments, the invention includes two memory arrays (each having capacity to store one or more N.times.M image data blocks), and an analyzer connected between the memory arrays. The analyzer receives horizontal vectors (such as full rows) of an image data block stored in the first memory, transforms each horizontal vector into two vectors (each comprising half as many words as the horizontal vector), interleaves the two vectors, and writes the resulting interleaved data (an orthogonal representation of the horizontal vector) into a row of the second memory.