Patents Assigned to Immtech International Inc.
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Patent number: 6703219Abstract: The invention provides a mutant protein which has the same amino acid sequence as an unmutated C-reactive protein (CRP) subunit or an unmutated preCRP, except that at least one amino acid of the unmutated CRP subunit or unmutated preCRP has been deleted, at least one amino acid of the unmutated CRP subunit or unmutated preCRP has been replaced by another amino acid, at least one amino acid has been added to the unmutated CRP subunit or preCRP, or a combination of such changes has been made. The amino acid(s) added, deleted and/or replaced are chosen so that the mutant protein is less likely to form covalently cross-linked aggregates than the unmutated CRP subunit or unmutated preCRP. The mutant protein also exhibits at least one of the biological activities of modified-CRP.Type: GrantFiled: March 22, 1999Date of Patent: March 9, 2004Assignee: Immtech International Inc.Inventors: Lawrence A. Potempa, Hans H. Liao, Becky L. Crump
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Publication number: 20030021798Abstract: The invention provides a method of enhancing an immune response to an immunogen in an animal. The method comprises administering to the animal an effective amount of the immunogen and an effective amount of a modified C-reactive protein (mCRP) or a mutant-mCRP. The invention also provides a vaccine and a method of producing this vaccine. The vaccine comprises an immunogen and an mCRP or a mutant-mCRP in a pharmaceutically-acceptable vehicle. The invention further provides a kit for immunizing an animal to an immunogen comprising (1) a container holding the immunogen and a container holding an mCRP or a mutant-mCRP or (2) a container holding the immunogen and an mCRP or a mutant-mCRP.Type: ApplicationFiled: September 24, 2002Publication date: January 30, 2003Applicant: Immtech International Inc.Inventors: Lawrence A. Potempa, James A. Radosevich
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Patent number: 6455046Abstract: The invention provides a method of enhancing an immune response to an immunogen in an animal. The method comprises administering to the animal an effective amount of the immunogen and an effective amount of a modified C-reactive protein (mCRP) or a mutant-mCRP. The invention also provides a vaccine and a method of producing this vaccine. The vaccine comprises an immunogen and an mCRP or a mutant-mCRP in a pharmaceutically-acceptable vehicle. The invention further provides a kit for immunizing an animal to an immunogen comprising (1) a container holding the immunogen and a container holding an mCRP or a mutant-mCRP or (2) a container holding the immunogen and an mCRP or a mutant-mCRP. The invention also provides a method of elicing an immune response to a hapten in an animal. The method comprises administering to the animal an effective amount of the hapten in association with an an effective amount of an mCRP or a mutant-mCRP. The invention further provides a vaccine and a method of producing this vaccine.Type: GrantFiled: May 9, 2000Date of Patent: September 24, 2002Assignee: Immtech International, Inc.Inventors: Lawrence A. Potempa, James A. Radosevich
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Publication number: 20020037535Abstract: The invention provides a method of slowing cell growth and promoting the maturation of cells other than cancer cells and megakaryocyte progenitor cells. The method comprises contacting the cells with a modified C-reactive protein (mCRP) or a mutant-mCRP. The method may be performed in vitro or in vivo.Type: ApplicationFiled: September 19, 2001Publication date: March 28, 2002Applicant: Immtech International Inc.Inventors: Lawrence A. Potempa, James A. Radosevich
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Patent number: 6280743Abstract: The invention provides a method of enhancing an immune response to an immunogen in an animal. The method comprises administering to the animal an effective amount of the immunogen and an effective amount of a modified C-reactive protein (mCRP) or a mutant-mCRP. The invention also provides a vaccine and a method of producing this vaccine. The vaccine comprises an immunogen and an mCRP or a mutant-mCRP in a pharmaceutically-acceptable vehicle. The invention further provides a kit for immunizing an animal to an immunogen comprising (1) a container holding the immunogen and a container holding an mCRP or a mutant-mCRP or (2) a container holding the immunogen and an mCRP or a mutant-mCRP. The invention also provides a method of elicing an immune response to a hapten in an animal. The method comprises administering to the animal an effective amount of the hapten in association with an an effective amount of an mCRP or a mutant-mCRP. The invention further provides a vaccine and a method of producing this vaccine.Type: GrantFiled: May 9, 2000Date of Patent: August 28, 2001Assignee: Immtech International, Inc.Inventors: Lawrence A. Potempa, James A. Radosevich
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Patent number: 6239099Abstract: The invention provides methods and compositions for treating viral infections in a mammal comprising administering a effective amount of modified C-reactive protein (CRP), rmCRP or mutant CRP to the mammal. The viral infections treated are caused by viruses such as Herpes, papilloma, Epstein Barr and Retroviridae viruses. In particular, modified-CRP has been found to be effective and safe for treating retroviral infections, including human immunodeficiency virus 1. The invention also provides a method of neutralizing a virus comprising contacting the virus with the CRP compositions. In particular, modified-CRP can be used to neutralize viruses in blood which is to be used for transfusions by adding the modified-CRP to the blood prior to the transfusion.Type: GrantFiled: December 17, 1996Date of Patent: May 29, 2001Assignee: Immtech International, Inc.Inventor: Lawrence A. Potempa
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Patent number: 6190670Abstract: The invention provides a method of enhancing an immune response to an immunogen in an animal. The method comprises administering to the animal an effective amount of the immunogen and an effective amount of a modified C-reactive protein (mCRP) or a mutant-mCRP. The invention also provides a vaccine and a method of producing this vaccine. The vaccine comprises an immunogen and an mCRP or a mutant-mCRP in a pharmaceutically-acceptable vehicle. The invention further provides a kit for immunizing an animal to an immunogen comprising (1) a container holding the immunogen and a container holding an mCRP or a mutant-mCRP or (2) a container holding the immunogen and an mCRP or a mutant-mCRP. The invention also provides a method of elicing an immune response to a hapten in an animal. The method comprises administering to the animal an effective amount of the hapten in association with an an effective amount of an mCRP or a mutant-mCRP. The invention further provides a vaccine and a method of producing this vaccine.Type: GrantFiled: August 18, 1999Date of Patent: February 20, 2001Assignee: Immtech International Inc.Inventors: Lawrence A. Potempa, James A. Radosevich
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Patent number: 6051415Abstract: The invention provides methods for stimulating thrombocytopoiesis in a mammal comprising administering to the mammal an effective amount of modified C-reactive protein ("mCRP") or mutant protein expressing neo-CRP antigenicity. Methods for treating thrombocytopenia, and for promoting megakaryocyte growth and maturation in vitro are also provided. Kits and articles of manufacture are further provided which include mCRP or mutant protein expressing neo-CRP antigenicity.Type: GrantFiled: October 27, 1995Date of Patent: April 18, 2000Assignee: Immtech International, Inc.Inventor: Lawrence A. Potempa
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Patent number: 5939529Abstract: The invention provides methods for stimulating thrombocytopoiesis in a mammal comprising administering to the mammal an effective amount of modified C-reactive protein ("mCRP") or mutant protein expressing neo-CRP antigenicity. Methods for treating thrombocytopenia, and for promoting megakaryocyte growth and maturation in vitro are also provided. Kits and articles of manufacture are further provided which include mCRP or mutant protein expressing neo-CRP antigenicity.Type: GrantFiled: October 27, 1995Date of Patent: August 17, 1999Assignee: Immtech International Inc.Inventor: Lawrence A. Potempa
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Patent number: 5874238Abstract: The invention provides a mutant protein which has the same amino acid sequence as an unmutated C-reactive protein (CRP) subunit or an unmutated preCRP, except that at least one amino acid of the unmutated CRP subunit or unmutated preCRP has been deleted, at least one amino acid of the unmutated CRP subunit or unmutated preCRP has been replaced by another amino acid, at least one amino acid has been added to the unmutated CRP subunit or preCRP, or a combination of such changes has been made. The amino acid(s) added, deleted and/or replaced are chosen so that the mutant protein is less likely to form covalently cross-linked aggregates than the unmutated CRP subunit or unmutated preCRP. The mutant protein also exhibits at least one of the biological activities of modified-CRP.Type: GrantFiled: June 7, 1995Date of Patent: February 23, 1999Assignee: Immtech International Inc.Inventors: Lawrence A. Potempa, Hans H. Liao, Becky L. Crump
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Patent number: 5702904Abstract: The invention provides an antibody which reacts selectively with a transferrin homolog found in alcoholics but not in non-alcoholics. The invention also provides methods of making the antibody and hybridomas producing the antibody. Finally, the invention provides an immunoassay which utilizes the antibody to detect or quantitate the alcoholic transferrin homolog and a kit for an immunoassay which comprises a container of the antibody.Type: GrantFiled: July 8, 1994Date of Patent: December 30, 1997Assignees: Immtech International, Inc., Northwestern UniveristyInventors: Samar Makhlouf, Mark L. Pankow, Byron E. Anderson, Pamela Bean
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Patent number: 5585349Abstract: The invention provides a method of treating a viral infection in a mammal comprising administering an effective amount of modified C-reactive protein (CRP) to the mammal. In particular, modified-CRP has been found to be effective and safe for treating retroviral infections, including human immunodeficiency virus 1. The invention also provides a method of neutralizing a virus comprising contacting the virus with modified-CRP. In particular, modified-CRP can be used to neutralize viruses in blood which is to be used for transfusions by adding the modified-CRP to the blood prior to the transfusion.Type: GrantFiled: September 7, 1993Date of Patent: December 17, 1996Assignee: Immtech International, Inc.Inventor: Lawrence A. Potempa
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Patent number: 5547931Abstract: The invention provides methods for stimulating thrombocytopoiesis and for treating thrombocytopenia in a mammal comprising administering to the mammal an effective amount of modified C-reactive protein (mCRP).Type: GrantFiled: February 23, 1994Date of Patent: August 20, 1996Assignee: Immtech International Inc.Inventor: Lawrence A. Potempa
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Patent number: 5405832Abstract: A method of treating non-Streptococcal bacterial infections in a mammal comprising administering to the mammal an effective amount of modified C-reactive protein (CRP) in a pharmaceutically-acceptable carrier. Modified-CRP has been found to be particularly effective in treating gram-negative bacterial infections and endotoxic shock.Type: GrantFiled: November 27, 1991Date of Patent: April 11, 1995Assignee: Immtech International Inc.Inventor: Lawrence A. Potempa
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Patent number: 5283238Abstract: The invention provides a method of treating cancer in a mammal comprising administering to the mammal an effective amount of modified C-reactive protein ("mCRP"). The invention also provides a method of treating cancer in a mammal comprising administering to the mammal mCRP in combination with another agent such as a chemotherapeutic compound, immunoadjuvant, or cytokine. The mCRP may be administered to the mammal in a pharmaceutically-acceptable carrier or in liposomes. The invention further provides a method of identifying cancer cells in a mammal using mCRP as an imaging agent.Type: GrantFiled: April 24, 1992Date of Patent: February 1, 1994Assignees: Immtech International, Inc., Northwestern UniversityInventors: Lawrence A. Potempa, John J. Kresl, Byron E. Anderson