Patents Assigned to Immune Complex Corporation
  • Strategically modified hepatitis B core proteins and their derivatives
    Patent number: 6231864
    Abstract: A strategically modified hepatitis B core protein is described, where an insert is provided, preferably in an immunodominant region of the nucleocapsid protein, containing a chemically reactive amino acid residue. The modified hepatitis B core protein or its aggregated nucleocapsid protein particles can be pendently linked to a hapten to form a modified nucleocapsid conjugate. Such a conjugate is useful in the preparation of vaccines or antibodies. The modified hepatitis B core protein can also be modified to include a T cell epitope.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: May 15, 2001
    Assignee: Immune Complex Corporation
    Inventor: Ashley J. Birkett