Patents Assigned to Immune Modulation, Inc.
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Patent number: 10857122Abstract: New uses of hypoestoxide, its derivatives and related compounds for treatment and prevention of neurodegenerative diseases (e.g. Parkinsons disease, Alzheimers disease, Huntingtons disease) are described. More specifically, the invention relates to methods for treating various neurodegenerative diseases through administration of hypoestoxide, its derivatives and related compounds, or a combination thereof to a subject with a neurodegenerative disease such that the symptoms of the disease are treated or at least partially alleviated. Furthermore, the present invention further provides methods of preventing the development of neurodegenerative diseases in individuals who are predisposed to developing a neurodegenerative disease over time.Type: GrantFiled: February 3, 2016Date of Patent: December 8, 2020Assignee: IMMUNE MODULATION, INC.Inventors: Howard Cottam, Emmanuel Ojo-Amaize, Emeka Nchekwube, Olusola Oyemade
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Patent number: 8124654Abstract: Novel diterpene compounds, in particular, hypoestoxide-related compounds, are provided in pure form or as contained in the native plant source, for treatment and prophylaxis of cancer, inflammatory diseases, hyperlipidemias, malaria, and diabetes mellitus. Embodiments also pertain to methods for using the hypoestoxide-related compounds to treat various diseases and symptoms associated with those diseases.Type: GrantFiled: November 11, 2008Date of Patent: February 28, 2012Assignee: Immune Modulation, Inc.Inventors: Howard B. Cottam, Emmanuel A. Ojo-Amaize, Emeka J. Nchekwube, Olusola A. Oyemade, Donna G. Nchekwube
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Publication number: 20100120853Abstract: Novel diterpene compounds, in particular, hypoestoxide-related compounds, are provided in pure form or as contained in the native plant source, for treatment and prophylaxis of cancer, inflammatory diseases, hyperlipidemias, malaria, and diabetes mellitus. Embodiments also pertain to methods for using the hypoestoxide-related compounds to treat various diseases and symptoms associated with those diseases.Type: ApplicationFiled: November 11, 2008Publication date: May 13, 2010Applicant: IMMUNE MODULATION, INC.Inventors: Howard B. Cottam, Emmanuel A. Ojo-Amaize, Emeka J. Nchekwube, Olusola A. Oyemade, Donna G. Nchekwube
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Patent number: 7229979Abstract: Methods of treating a host suffering from restenosis are provided. The methods include delivery of a stent coated with a hypoestoxide, hypoestoxide derivative or hypoestoxide agonist compound to a vessel. The methods further include the administration of a chemotherapeutic agent in combination with delivery of a stent coated with a hypoestoxide, hypoestoxide derivative or hypoestoxide agonist compound to a vessel. The chemotherapeutic agent may be coated on the stent or administered systemically.Type: GrantFiled: June 23, 2004Date of Patent: June 12, 2007Assignee: Immune Modulation, Inc.Inventors: Emeka J. Nchekwube, Emmanuel A. Ojo-Amaize, Howard B. Cottam
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Patent number: 6001871Abstract: A method for inhibiting the growth of lentiviruses and Herpetoviridae viruses, including HIV-1 and HSV-1, -2, respectively, in subjects, comprising administering to a subject in need of antiviral therapy a pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula ##STR1## where: R is(i) H, PO.sub.3.sup..dbd., alkyl of 1 to 12 carbon atoms substituted or unsubstituted, straight chain or branched, 0 to 6 double bonds, (CH.sub.2).sub.n morpholine where n=1-4, morpholinomethylphenyl, orthoaminophenyl, orthohydroxyphenyl, (CH.sub.2).sub.n COOR.sub.2 where n=1-4where R.sub.2 is H, an alkalai metal salt, an alkaline earth metal salt, NH.sub.4.sup..dbd., N.sup.+ (R.sub.3).sub.4where R.sub.3 is independently selected from the group consisting of H and alkyl of 1 to 4 carbon atoms, or(ii) COR.sub.1 wherein R.sub.1 is selected from the group consisting of H, (CH.sub.2).sub.n CH.sub.3, where n=0-6, (CH.sub.2).sub.n COOR.sub.2 where n=1-4 and R.sub.2 is previously defined, (CH.Type: GrantFiled: January 15, 1998Date of Patent: December 14, 1999Assignee: Immune Modulation, Inc.Inventors: Emmanuel A. Ojo-Amaize, Joseph I. Okogun
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Patent number: 5994328Abstract: A method for inhibiting the growth of cancer cells ous tumors. The method comprises administering to a subject in need of anticancer or antitumor therapy a pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula ##STR1## where: R is(i) H, PO.sub.3.sup..dbd., alkyl of 1 to 12 carbon atoms substituted or unsubstituted, straight chain or branched, 0 to 6 double bonds, (CH.sub.2).sub.n morpholine where n=1-4, morpholinomethylphenyl, orthoaminophenyl, orthohydroxyphenyl, (CH.sub.2).sub.n COOR.sub.2 where n=1-4where R.sub.2 is H, an alkali metal salt, an alkaline earth metal salt, NH.sub.4.sup.+, N.sup.+ (R.sub.3).sub.4 where R.sub.3 is independently selected from the group consisting of H and alkyl of 1 to 4 carbon atoms, or(ii) COR.sub.1 wherein R.sub.1 is selected from the group consisting of H, (CH.sub.2).sub.n CH.sub.3, where n=0-6, (CH.sub.2).sub.n COOR.sub.2 where n=1-4 and R.sub.2 is previously defined, (CH.sub.2).sub.n N.sup.+ (R.sub.3).sub.Type: GrantFiled: January 14, 1998Date of Patent: November 30, 1999Assignee: Immune Modulation, Inc.Inventors: Emmanuel A. Ojo-Amaize, Vellalore N. Kakkanaiah, Joseph I. Okogun
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Patent number: 5968912Abstract: Methods for inducing immunosuppression in animals which need immunosuppressive treatment involving administration to animals of a therapeutically effective amount of the cyclic AMP agent HE-33 or its nucleoside.Type: GrantFiled: July 25, 1997Date of Patent: October 19, 1999Assignee: Immune Modulation, Inc.Inventor: Emmanuel A. Ojo-Amaize
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Patent number: 5801193Abstract: Methods and compounds for inducing immunosuppression in animals which need immunosuppressive treatment involving administration to animals of a therapeutically effective amount of a compound of the following formula ##STR1## where R is H, PO.sub.3.sup.=, alkyl of 1 to 12 carbon atoms substituted or unsubstituted, straight chain or branched, 0 to 6 double bonds, (CH.sub.2).sub.n morpholine where n=1-4, morpholinomethylphenyl, orthoaminophenyl, orthohydroxyphenyl, (CH.sub.2).sub.n COOR.sub.2 where n=1-4where R.sub.2 is H, an alkalai metal salt, an alkaline earth metal salt, NH.sub.4.sup.+, N.sup.+ (R.sub.3).sub.4 where R.sub.3 is independently selected from the group consisting of H and alkyl of 1 to 4 carbon atoms,COR.sub.1 wherein R.sub.1 is selected from the group consisting of H, (CH.sub.2).sub.n CH.sub.3, where n=1-6, (CH.sub.2).sub.n COOR.sub.2 where n=1-4 and R.sub.2 is previously defined, (CH.sub.2).sub.n N.sup.+ (R.sub.3).sub.4 wherein n=1-4, and (CH.sub.2).sub.n SO.sub.3.sup.Type: GrantFiled: April 15, 1997Date of Patent: September 1, 1998Assignee: Immune Modulation, Inc.Inventors: Emmanuel A. Ojo-Amaize, Joseph I. Okogun, Howard B. Cottam
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Patent number: 5747474Abstract: Methods for inducing immunosuppression in animals which need immunosuppressive treatment involving administration to animals of a therapeutically effective amount of the cyclic AMP agent HE-33 or its nucleoside.Type: GrantFiled: July 29, 1996Date of Patent: May 5, 1998Assignee: Immune Modulation, Inc.Inventors: Emmanuel A. Ojo-Amaize, Howard B. Cottam, Ganesh D. Kini