Abstract: The present invention provides an anti-idiotypic antibody having specific reactivity with an idiotope common to more than one type of anti-HIV-1 antibody, and having no specific reactivity with non-HIV-1 antibodies. The present invention provides methods of diagnosis, monitoring and treatment of HIV-related diseases through the use of this antibody or related compounds.

Abstract: Substances that bind to alloimmune-immunogen-absorbed (AIA) sera have been found to be effective in the prevention and therapy of autoimmune disease. It is conjectured that the mechanism involves indirect stimulation of suppressor T cells resulting in stabilization of the immune system. The administration of such substances is expected to be useful in the prevention and treatment of diseases that involve a failure of the immune system to distinguish adequately between self and nonself, including autoimmune diseases and immunodeficiency diseases.