Patents Assigned to Immune Targeting, Inc.
  • Activatable IL2 composition and methods of use
    Patent number: 11597753
    Abstract: The present invention includes proteins, nucleic acids and methods of making and using an activatable interleukin-2 (aIL2) comprising an Interleukin-2 (aIL2) fusion protein comprising: an Interleukin-2 (IL2) wild-type or mutein; a first cleavable linker; an interleukin-2 receptor binding region (IL2RB), and a half-life extender, such as an antibody Fc region, wherein cleavage of the cleavable linker releases the IL2 from the interleukin-2 receptor beta binding region.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: March 7, 2023
    Assignee: Immune Targeting, Inc.
    Inventors: Tao Yue, Yang Wang