Patents Assigned to ImmuneSensor Therapeutics, Inc.
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Patent number: 12134609Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.Type: GrantFiled: June 13, 2023Date of Patent: November 5, 2024Assignees: IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Jian Qiu, Qi Wei, Matt Tschantz, Heping Shi, Youtong Wu, Huiling Tan, Lijun Sun, Chuo Chen, Zhijian Chen
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Patent number: 12091387Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.Type: GrantFiled: July 17, 2023Date of Patent: September 17, 2024Assignees: IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Qi Wei, Heping Shi, Matt Tschantz, Jian Qiu, Youtong Wu, Huiling Tan, Lijun Sun, Chuo Chen, Zhijian Chen
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Patent number: 12065416Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.Type: GrantFiled: January 23, 2023Date of Patent: August 20, 2024Assignees: IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Boyu Zhong, Lijun Sun, Heping Shi, Jing Li, Chuo Chen, Zhijian Chen
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Patent number: 11873291Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.Type: GrantFiled: September 3, 2021Date of Patent: January 16, 2024Assignees: IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Jian Qiu, Qi Wei, Matt Tschantz, Heping Shi, Youtong Wu, Hulling Tan, Lijun Sun, Chuo Chen, Zhijian Chen
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Publication number: 20230081291Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.Type: ApplicationFiled: September 3, 2021Publication date: March 16, 2023Applicants: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas SystemInventors: Jian QIU, Qi WEI, Matt TSCHANTZ, Heping SHI, Youtong WU, Huiling TAN, Lijun SUN, Chuo CHEN, Zhijian CHEN
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Patent number: 11597707Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.Type: GrantFiled: March 3, 2021Date of Patent: March 7, 2023Assignees: IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Boyu Zhong, Lijun Sun, Heping Shi, Jing Li, Chuo Chen, Zhijian Chen
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Publication number: 20220356158Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.Type: ApplicationFiled: March 3, 2021Publication date: November 10, 2022Applicants: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas SystemInventors: Boyu ZHONG, Lijun SUN, Heping SHI, Jing LI, Chuo CHEN, Zhijian CHEN
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Patent number: 11299512Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.Type: GrantFiled: June 11, 2019Date of Patent: April 12, 2022Assignees: IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Boyu Zhong, Heping Shi, Yuanwei Dai, Qi Wei, Chuo Chen, Zhijian Chen, Lijun Sun
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Patent number: 11213592Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.Type: GrantFiled: May 11, 2021Date of Patent: January 4, 2022Assignees: IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Zhijian Chen, Heping Shi, Qi Wei, Chuo Chen, Lijun Sun, Jian Qiu, Youtong Wu
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Publication number: 20210380695Abstract: The disclosure provides, among other things, methods and uses for treating a disease or disorder, particularly a cancer, in a patient, comprising conjointly administering a CTLA4 inhibitor (e.g., an anti-CTLA4 antibody) and a STING agonist to the patient, wherein the CTLA4 inhibitor is administered intratumorally to the patient. The STING agonist can be administered intratumorally, orally or systemically (e.g., intravenously, intramuscularly, or subcutaneously) to the patient.Type: ApplicationFiled: May 17, 2021Publication date: December 9, 2021Applicants: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas SystemInventors: Zhijian CHEN, Lijun SUN
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Publication number: 20210290774Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.Type: ApplicationFiled: May 11, 2021Publication date: September 23, 2021Applicants: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas SystemInventors: Zhijian CHEN, Heping SHI, Qi WEI, Chuo CHEN, Lijun SUN, Jian QIU, Youtong WU
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Patent number: 11033635Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.Type: GrantFiled: July 20, 2020Date of Patent: June 15, 2021Assignees: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas SystemInventors: Zhijian Chen, Heping Shi, Qi Wei, Chuo Chen, Lijun Sun, Jian Qiu, Youtong Wu
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Patent number: 10947206Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.Type: GrantFiled: April 15, 2018Date of Patent: March 16, 2021Assignees: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas SystemInventors: Boyu Zhong, Lijun Sun, Heping Shi, Jing Li, Chuo Chen, Zhijian Chen
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Publication number: 20210015941Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.Type: ApplicationFiled: July 20, 2020Publication date: January 21, 2021Applicants: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas SystemInventors: Zhijian CHEN, Heping SHI, Qi WEI, Chuo CHEN, Lijun SUN, Jian QIU, Youtong WU
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Publication number: 20200010501Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.Type: ApplicationFiled: June 11, 2019Publication date: January 9, 2020Applicants: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas SystemInventors: Boyu ZHONG, Heping SHI, Yuanwei DAI, Qi WEI, Chuo CHEN, Zhijian CHEN, Lijun SUN
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Patent number: 10519188Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.Type: GrantFiled: April 15, 2018Date of Patent: December 31, 2019Assignees: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas SystemInventors: Boyu Zhong, Lijun Sun, Heping Shi, Qi Wei, Yuanwei Dai, Chuo Chen, Zhijian Chen
