Abstract: Methods and compositions for the treatment of inflammatory bowel diseases, chemically-induced irritation and inflammation, and other irritative or inflammatory conditions utilizing the peptide sequences Asp-Ser-Asp-Pro-Arg, Asp-Ser-Asn-Pro-Arg, or derivatives or salts thereof are disclosed.
Abstract: Methods and compositions for the treatment of non-IgE-mediated inflammatory disease conditions utilizing the peptide Asp-Ser-Asp-Pro-Arg, or derivative thereof are disclosed.
Abstract: Anti-inflammatory peptides of the formula A-B-C-D-E, useful in treating allergies, autoimmune diseases, and other disorders, and methods for using them are described.
Abstract: A method of modulating immune responses in mammals by blocking immune complex binding to immunoglobulin Fc receptors is described, comprising administering a peptide comprising a portion selected from the amino acid sequence-Pro-Asp-Ala-Arg-His-Ser-Thr-Thr-Gln-Pro-Arg-Specific uses in reducing immune complex mediated inflammation or tissue destruction and in reducing the human allergic response are disclosed.
Abstract: A method of modulating immune complex mediated immune responses in mammals is described, comprising administering a peptide comprising the amino acid sequence-Thr-Ile-Ser-Lys-Ala-Lys-Gly-Gln-Pro-Arg-Specific uses in reducing immune complex mediated inflammation or tissue destruction and in modulating the proliferation or function of mononuclear cells are disclosed.
Abstract: Peptides and peptide compositions are disclosed which act as competitive antagonists for the C5a receptor and thus block inflammatory and immunomodulatory activity mediated by endogenous C5a.
Abstract: A peptide having the amino acid sequence Asp-Ser-Glu-Pro-Arg and capable of blocking immune complex binding to immunoglobulin Fc receptors is disclosed.