Abstract: There is disclosed a complex comprised of an insoluble polymer carrier to which monomeric human albumin is covalently bound and of a pre-S hepatitis B surface antigen bound in an elutable form to the monomeric human albumin by its pre-S(2)- and/or pre-S(1)-region. This complex may be used for therapeutic and diagnostic purposes and enables the rapid and efficient purification of pre-S-HBsAg by affinity chromatography.
Type:
Grant
Filed:
November 8, 1991
Date of Patent:
December 28, 1993
Assignee:
Immuno A.G.
Inventors:
Johann Eibl, Friedrich Dorner, Artur Mitterer