Patents Assigned to ImmunoBiology Limited
-
Patent number: 10669563Abstract: The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular, there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress inducing stimuli. The invention further extends to the use of heat shock protein complexes produced according to the methods of the invention in the preparation of vaccine compositions for the prevention and treatment of infectious diseases and cancerous conditions.Type: GrantFiled: February 7, 2019Date of Patent: June 2, 2020Assignee: Immunobiology LimitedInventors: Camilo Colaco, Ian McEntee
-
Patent number: 10240179Abstract: The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular, there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress inducing stimuli. The invention further extends to the use of heat shock protein complexes produced according to the methods of the invention in the preparation of vaccine compositions for the prevention and treatment of infectious diseases and cancerous conditions.Type: GrantFiled: March 23, 2012Date of Patent: March 26, 2019Assignee: Immunobiology LimitedInventors: Camilo Colaco, Ian McEntee
-
Patent number: 10040820Abstract: The present invention provides an improved method for the purification of a mixture of complexes comprising a stress protein complexed to a peptide or peptide fragment from a source mixture, typically a cell lysate. The method of the invention provides for protein complexes to be purified using ion exchange chromatography based methods, wherein a modified buffer solution is used which results in the purified stress protein complexes being more immunogenic than protein complexes obtained using conventional methodology. The purified complexes can be used to produce improved vaccine preparations which elicit enhanced immune responses in the subjects to whom the vaccine compositions are administered.Type: GrantFiled: June 21, 2010Date of Patent: August 7, 2018Assignee: Immunobiology LimitedInventors: Camilo Colaco, Colin Richard Bignell
-
Publication number: 20140017274Abstract: The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular, there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress inducing stimuli. The invention further extends to the use of heat shock protein complexes produced according to the methods of the invention in the preparation of vaccine compositions for the prevention and treatment of infectious diseases and cancerous conditions.Type: ApplicationFiled: March 23, 2012Publication date: January 16, 2014Applicant: Immunobiology LimitedInventors: Camilo Colaco, Ian Mcentee
-
Publication number: 20120135029Abstract: The present invention provides an improved method for the purification of a mixture of complexes comprising a stress protein complexed to a peptide or peptide fragment from a source mixture, typically a cell lysate. The method of the invention provides for protein complexes to be purified using ion exchange chromatography based methods, wherein a modified buffer solution is used which results in the purified stress protein complexes being more immunogenic than protein complexes obtained using conventional methodology. The purified complexes can be used to produce improved vaccine preparations which elicit enhanced immune responses in the subjects to whom the vaccine compositions are administered.Type: ApplicationFiled: June 21, 2010Publication date: May 31, 2012Applicant: IMMUNOBIOLOGY LIMITEDInventors: Camilo Colaco, Colin Richard Bignell
-
Publication number: 20110206725Abstract: The present invention provides a method for the purification of complexes comprising a stress protein complexed to a peptide or peptide fragment, from a source mixture, typically a cell lysate. The improved method of the invention provides for protein complexes to be purified using ion exchange based methods, without the need to use chemicals such as chaotropes and ampholytes. The purified complexes can be used as the immunogenic determinant in vaccine compositions for the treatment or prevention of infectious diseases or cancerous conditions.Type: ApplicationFiled: September 7, 2009Publication date: August 25, 2011Applicant: IMMUNOBIOLOGY LIMITEDInventors: Camilo Colaco, Kamram Salim
-
Publication number: 20090186025Abstract: The present invention provides a fusion protein comprising an Fc receptor binding polypeptide and an antigenic polypeptide. The fusion peptide may further comprise a linker sequence or hinge portion which joins the Fc receptor biding polypeptide and the antigenic polypeptide. The Fc receptor binding polypeptide typically comprises the CH2 constant domain of a human IgG immunoglobulin. The antigenic polypeptide can be any polypeptide which induces an immune response. Administration of the fusion protein to a subject results in a cytotoxic T lymphocyte response being induced against the antigenic polypeptide provided within the fusion protein. The invention further extends to methods for the treatment of a disease condition in a subject using the fusion proteins of the invention.Type: ApplicationFiled: March 22, 2007Publication date: July 23, 2009Applicant: ImmunoBiology LimitedInventor: Camilo Colaco
-
Publication number: 20070243200Abstract: The present invention relates to methods for using prokaryotic cells which have been modified or induced to synthesize trehalose as vaccines and to vaccine compositions obtained thereby.Type: ApplicationFiled: May 29, 2007Publication date: October 18, 2007Applicant: ImmunoBiology LimitedInventor: Camilo Anthony Leo Colaco