Abstract: The present invention concerns an in vitro test for detecting the irritant potential of chemicals combining a corneal cell model with a selection of predictive and qualitative molecular markers to classify compounds into 3 categories, namely irreversible eye damage 21 days after application (category 1), reversible eye damage 21 days after application (category 2) and no irritation (no category). The inventors have thus demonstrated that the response following the action of an irritant substance occurs directly on an in vitro reconstructed corneal epithelium, and that the degree of irritation and the qualification of this irritation of a molecule may be determined by the use of specific biomarkers of eye irritation.

Abstract: The invention relates to a method for evaluating the sensitizing potential of a test compound, and to a kit for implementing said method.

Abstract: The invention relates to novel polypeptides and to the use thereof for the in vitro assessment of the sensitizing potential of a test compound, to a method for the in vitro assessment of the sensitizing potential of a test compound, to an in vitro method for selecting a compound suitable for reducing the sensitization, as well as to kits for implementing such methods.

Abstract: The invention relates to a device for analysing the effects of at least one parameter related to a volatile substance on a living test system, characterised in that it comprises: an enclosure (1) composed of a first compartment (20) comprising a gas inlet (21) and a gas outlet (22), and a second compartment (30) in which the test system and the volatile substance are located, the first (20) and second (30) compartments communicating with each other through an opening (11) fitted with a semi-permeable membrane (40) adapted to limit a flow of volatile substance from the second compartment (30) to the first compartment (20) in a determined manner, while allowing a gas flow from the first compartment (20) to the second compartment, (30), and the second compartment (30) being hermetically sealed such that the only exchanges with an outside medium take place towards the first compartment (20), through the membrane (40).

Abstract: The invention relates to a method for evaluating the sensitizing potential of a test compound, and to a kit for implementing said method.

Abstract: The invention relates to novel polypeptides and to the use thereof for the in vitro assessment of the sensitising potential of a test compound, to a method for the in vitro assessment of the sensitising potential of a test compound, to an in vitro method for selecting a compound suitable for reducing the sensitisation, as well as to kits for implementing such methods.