Patents Assigned to Imperial Cancer Res. Technology
  • Screening assays for hedgehog agonists and antagonists
    Patent number: 6261786
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: July 2, 1996
    Date of Patent: July 17, 2001
    Assignees: Imperial Cancer Res. Technology, President & Fellows of Harvard College
    Inventors: Valeria Marigo, Clifford J. Tabin, Philip W. Ingham, Andrew P. McMahon