Patents Assigned to Imperial Cancer Research Technology Institute
  • Vertebrate embryonic pattern-inducing proteins and uses related thereto
    Patent number: 7144732
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: December 5, 2006
    Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Institute
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin