Abstract: The invention relates to inorganic-organic hybrid materials comprising interpenetrated organic and inorganic components, wherein the organic component comprises polymer chains formed at least in part by ring-opening polymerization of a cyclic monomer, and processes for the production thereof.

Abstract: This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).

Abstract: A method of forming a part from sheet metal and a part formed by said method. The method comprising the steps of: (a) heating a metal sheet to a temperature T; and (b) forming the sheet into the part between dies while applying cooling means to the sheet, where in step a) the metal sheet is heated at a rate of at least 50° C.s?1, and temperature T is above a critical forming temperature and does not exceed a critical microstructure change temperature of said metal sheet.

Abstract: A method of measuring Gadd45? expression comprising the step of measuring Gadd45? expression levels in a sample of cells, for example CD 138 expressing cells, obtained from a subject known to have or suspected of having a haematological malignancy. Expression levels may be used in diagnosis, for example of multiple myeloma, in providing a prognosis, for example in a patient having multiple myeloma or in guiding selection of an appropriate treatment agent, especially a treatment agent comprising Gadd45? and or MKK7 inhibitors. Also datasets comprising measured expression levels from multiple subjects.

Abstract: Methods of treatment of disorders of the knee, such as medial osteoarthritis and knee instability due to anterior cruciate ligament deficiency, are provided herein.

Abstract: An oxidant production apparatus comprises an electrochemical reactant reservoir, an electrolysis compartment, a porous first electrode and a second electrode. The porous first electrode defines a boundary between the reservoir and the electrolysis compartment and is configured to allow an electrochemical reactant to pass from the reservoir, through the first electrode and into the electrolysis compartment. The second electrode disposed at least substantially in the electrolysis compartment and spaced apart from the first electrode. The apparatus is configured to produce an oxidant in an electrochemical reaction when a voltage is applied across the first and second electrodes and a current is passed through the first and second electrodes and an electrolyte disposed in the electrolysis compartment.

Abstract: Example embodiments described herein are directed towards dynamic state estimation of an operating state of a generator in a power system. Such estimation is performed for an individual generator in real time with improved accuracy and without the use of Global Position System (GPS) synchronization.

Abstract: A robotic vehicle has legs and propellers to enable it to walk, fly, and or swim.

Abstract: There is provided a method of using a device capable of controlled flight in a surrounding environment, the device comprising: lifting means for providing lift to the device; object-retaining means for holding an object to be affixed to a target site; and a dispensing assembly for dispensing an adhesive, wherein the method comprises: controlling the lifting means so as to controllably fly the device in the surrounding environment; and using the device to affix an object held by the object-retaining means to a target site in the surrounding environment by dispensing an adhesive from the dispensing assembly. Thus, an aerial device, for example a robotic device, may be used to fly to a desired location and affix an object at the desired location, by dispensing, ejecting or otherwise applying an adhesive.

Abstract: There is provided a method of manufacturing a component. The method comprises creating a preform from a material using additive manufacturing and heat treating the preform at a heating temperature to modify the microstructure of the material. The preform is geometrically unconstrained during the step of heat treating. The method then comprises compressive forming the preform into a predefined arrangement to create the component wherein the step of compressive forming is effective to close pores and diffusively bond the material. The material may then be geometrically constrained as it is cooled, for example within the die used for compressive forming.

Abstract: Systems and methods for autonomously herding birds in accordance with embodiments of the invention are illustrated. One embodiment includes an autonomous flock herding system, including a bird location sensor, a drone; and a control system, including a processor, and a memory, the memory containing a flock herding application, where the application directs the processor to obtain bird position data from the at least one bird location sensor, where the bird position data describes the location of birds in a flock of birds, determine if the flock of birds will enter a protected zone, generate a set of waypoints using a flock dynamics model, instruct the unmanned aerial vehicle to navigate to at least one waypoint in the set of waypoints such that the flock of birds will, in response to the presence of the unmanned aerial vehicle at the at least one waypoint, change trajectory away from the protected zone.

Abstract: A composition for aiding the removal of polyps, in the form of a submucosal injectable formulation, comprising one or more salts of hyaluronic acid, saline solution and indigo carmine, but not including a substance exhibiting an angiotonic effect such as epinephrine, norepinephrine, or isoproterenol is described. Further described are a method for removing a polyp from a mucous membrane, the composition for use in endoscopic procedures and a kit for use in an endoscopic procedure.

Abstract: Method of reducing the arsenic concentration in an aqueous solution comprising undesired arsenic, which method comprises contacting the aqueous solution with a complex of Formula (I), (Formula (I)) wherein M1 and M2 are the same or different and are independently selected from V, Mn, Ga, Cu, Ni, Co, Fe or Zn; wherein a is 0, or 1, and b is 0, or 1, provided that a+b together must be at least 1; Q is a negatively charged counter ion; n is from 1 to 5; X1 is OH, O, SH or S; L1 is a group selected from —La1-C(O)NR—, —La2-C(O)OR—, —La3-NRC(O)—, La4-OC(O)—, La5-O— or La6-NRO—, wherein La1, La2, La3, La4, La5 and La6 are each C1-6 alkyl, optionally substituted, R is H or C1-6 alkyl optionally substituted; Linker is a polyethylene glycol (PEG) chain with from 1 to 10 repeating units, a C1-16 polyamine chain or a C1-16 alkyl chain; Z is a solid support; L2 to L7 are independently C1-3 alkyl, optionally substituted; and Het1 to Het4 are independently 5 to 14 membered heteroaryl group having at least one N atom and opt

Abstract: The invention provides a targeted bacteriophage-polymer complex comprising a recombinant targeted-bacteriophage and a cationic polymer. The complex has a net positive charge. The invention provides methods of preparing bacteriophages and complexes thereof, and to their uses for the delivery of transgenes in a variety of gene therapy applications.

Abstract: A dual modality sensor comprises a tissue-contact electrode having a first surface configured for receiving an electrical signal from a user's tissue when attached thereto; and a mechanical sensor overlying the cutaneous electrode and configured to sense a mechanical displacement of the first surface through the electrode. The electrode and the mechanical sensor thereby provide electrical and mechanical signals which originate from precisely the same tissue location.

Abstract: The invention provides methods for inhibiting T-cell mediated rejection of a xenotransplanted organ by blocking the delivery of co-stimulatory signal 2 (the B7/CD28 interaction) prevent the activation of xenoreactive T-cells in the recipient. In a first aspect, co-stimulation is prevented by administration to the organ recipient of a soluble form of CTLA-4 from the xenogeneic donor organism. In a second aspect, co-stimulation is antagonized by expressing a ligand for CTLA-4 on the xenogeneic donor cells. In a third aspect, co-stimulation is prevented by expressing recipient organism MHC class II on the surface of the cells of the xenogeneic donor organ.

Abstract: A method of determining chromatin structure is described. The method comprises the steps of (i) fragmenting a nucleotide sequence at multiple HSs; and (ii) analysing fragments formed in step (i) from a plurality of sequences. In a preferred aspect, the present invention provides a method of determining chromatin structure in a nucleic acid sample comprising the steps of (i) treating the sample to fragment the nucleic acid therein at multiple HSs; and (ii) analysing fragments formed in step (i) from a plurality of genes.

Abstract: A component comprising a body including a roughened contact surface comprising peaks and valleys, and a conformal coating of a coating material at the roughened surface, wherein the roughened surface has a surface roughness which is such that the valleys define voids in which coating material is entrapped during wear of the component in exposing the body, with the entrapped coating material conferring improved wear resistance.

Abstract: A method for suppressing the expression of a selected gene in a cell, the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.

Abstract: The invention provides means and methods for inhibiting T-cell mediated rejection of a xenotransplanted organ by blocking the delivery of co-stimulatory signal 2 (the B7/CD28 interaction) in order to prevent the activation of xenoreactive T-cells in the recipient. In a first aspect, co-stimulation is prevented by administration to the organ recipient of a soluble form of CTLA-4 from the xenogeneic donor organism. This preferentially binds B7 on the xenograft and blocks the interaction between B7 on the xenogeneic donor cells and CD28 on recipient T-cells. In a second aspect, co-stimulation is antagonized by expressing a ligand for CTLA-4 on the xenogeneic donor cells. This ligand binds to CTLA-4 on activated T-cells of the recipient and antagonizes signal 2. In a third aspect, co-stimulation is prevented by expressing recipient organism MHC class II on the surface of the cells of the xenogeneic donor organ.