Abstract: A gene knock-in method for knocking in an exogenous DNA into a target site of a genomic DNA, the method comprising: a step of introducing a donor DNA that contains the exogenous DNA and a CRISPR-Cas9 system that includes a Cas9 protein and a guide RNA for the Cas9 protein as constituent elements into a cell, wherein the donor DNA contains in order from a 5? side: a 5?-microhomology region formed of a first? nucleotide sequence that is capable of being joined to a first nucleotide sequence on a 5? side of the target site of the genomic DNA by microhomology-mediated end joining; the exogenous DNA; and a 3?-microhomology region formed of a second? nucleotide sequence that is capable of being joined to a second nucleotide sequence on a 3? side of the target site of the genomic DNA by microhomology-mediated end joining, the CRISPR-Cas9 system cleaves, in the genomic DNA, a first cleavage target region between the target site and the first nucleotide sequence and a second cleavage target region between the targ

Abstract: An electricity measuring type surface plasmon resonance sensor includes: a plasmon resonance intensifying sensor chip in which a prism and a sensor chip including an electrode, a silicon semiconductor film, and a plasmon resonance film electrode arranged in this order are arranged in an order of the prism, the electrode, the silicon semiconductor film, and the plasmon resonance film electrode; and an electric measuring apparatus which directly measures a current or voltage from the electrode and the plasmon resonance film electrode.

Abstract: An electricity measuring type surface plasmon resonance sensor including: a plasmon polariton intensifying sensor chip in which a prism and a sensor chip including a transparent electrode, an n-type transparent semiconductor film, and a plasmon resonance film electrode arranged in this order are arranged in an order of the prism, the transparent electrode, the n-type transparent semiconductor film, and the plasmon resonance film electrode; and an electric measuring apparatus which directly measures a current or voltage from the transparent electrode and the plasmon resonance film electrode.

Abstract: There is provided a concentration sensor for measurement of concentrations of one or plural target substances in a system, with a detection electrode of conductive diamond. The measuring method with the concentration sensor involves measuring the reaction potentials of plural target substances in a sample containing and determining the concentrations of the plural substances by use of the difference between the resulting reaction potentials of the respective substances. The measuring method can also determine the concentration of a single substance in a sample containing one kind of target substance.

Abstract: A CO gas sensor according to the present invention includes a gas collecting container for collecting a measured gas therein; a detecting section provided within the gas collecting container and having at least a pair of electrodes positioned through electrolyte; and a voltage applying apparatus for applying voltage to the detecting section. One of the electrodes of the detecting section is a detection electrode having the capability of adsorbing at least one of hydrogenous gas and CO gas when a voltage is applied and then oxidizing it. By introducing a measured gas into a gas collecting container of the CO gas sensor and carrying out electrolysis according to a potential sweep method or a pulse method with the measured gas being in contact with the detecting section, a CO gas concentration in the measured gas can be measured based on an electrical current value obtained at the detecting section and changes of the electrical current with elapse of time.