Patents Assigned to Imreg, Inc.
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Patent number: 5100663Abstract: Compositions for delaying the progression from AIDS to ARC, and for alleviating symptoms of AIDS and ARC are disclosed together with clinical results of use of such compositions in clinical trials with of actual human patients suffering from these diseases. The compositions are based on a Tyr-Gly amino acid residue sequence. Typical dosage amounts are in the range of femtomoles/kg of body weight.Type: GrantFiled: January 24, 1990Date of Patent: March 31, 1992Assignee: Imreg, Inc.Inventor: A. Arthur Gottlieb
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Patent number: 5093321Abstract: Purified human leukocyte dialysates are described for treatment of AIDS, ARC, and other immunodeficient conditions. The dialysates are purified by HPLC processes, and are made available in a form that is free of endotoxin and pyrogen. A dialysate designated Beta-1.11 is found by amino acid sequencing to consist essentially of endogenous Tyr-Gly. A dialysate designated Beta-1.12 is found by amino acid sequencing to consist essentially of endogenous Tyr-Gly-Gly.Type: GrantFiled: January 24, 1990Date of Patent: March 3, 1992Assignee: Imreg, Inc.Inventor: A. A. Gottlieb
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Patent number: 5081108Abstract: Purified human leukocyte dialysates are described for treatment of AIDS, ARC, and other immunodeficient conditions. The dialysates are purified by HPLC processes, and are made available in a form that is free of endotoxin and pyrogen. Methods are described for slowing the progression from ARC to AIDS and for alleviating symptoms of AIDS and ARC, by administration of the dialysates. Methods for treating candidiasis and for increasing immune system response to recall antigen, by administration of the dialysates, are also described.Type: GrantFiled: January 24, 1990Date of Patent: January 14, 1992Assignee: Imreg, Inc.Inventor: A. Arthur Gottlieb
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Patent number: 5013546Abstract: Methods and compositions are described for increasing and decreasing immunoglobulin production by administering to a human or other mammalian subject an appropriate dosage of amplifier. Administration of amplifier to subjects having excessive production of immunoglobulin, namely AIDS and ARC patients, is shown as decreasing such excessive immunoglobulin production in such patients.Type: GrantFiled: March 29, 1990Date of Patent: May 7, 1991Assignee: Imreg, Inc.Inventors: A. Arthur Gottlieb, Robert C. Sizemore
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Patent number: 4920097Abstract: Methods of extracting an immunosuppressor from leukocyte dialysates are disclosed, together with methods for using the immunosuppressor and compositions containing the immunosuppressor.Type: GrantFiled: October 12, 1988Date of Patent: April 24, 1990Assignee: Imreg, Inc.Inventors: A. Arthur Gottlieb, Robert C. Sizemore, Sudhir K. Sinha
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Patent number: 4876193Abstract: Methods are described for assaying, in vitro, the capacity of a subject's lymphocytes to manifest suppressor function. PBLs are exposed to an agent stimulating suppressor cell formation and/or activation. Other PBLs are treated to induce a cell proliferative response, thereby producing responder cells. The responder cells are subjected to an antigen in the presence of the suppressor cells previously produced and in the presence of various concentrations of an amplifier. The procedure provides a means of ascertaining suppressor capacity of the subject's immune system, i.e., the subject's potential to express suppressor function, thereby permitting assay of severity of autoimmune disease, titrating dosage of immunomodulatory agents, and determining whether modulator therapy is feasible.Type: GrantFiled: February 24, 1986Date of Patent: October 24, 1989Assignee: Imreg, Inc. (Delaware corporation)Inventor: A. Arthur Gottlieb
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Patent number: 4874608Abstract: A method is described for treating mammalian solid tumors by administering leukocyte-derived amplifiers of the immune system to tumor-bearing subjects. The amplifiers include Beta-1.0, Beta-1.1, Beta-1,12, TG, and TGG.Type: GrantFiled: April 27, 1987Date of Patent: October 17, 1989Assignee: Imreg, Inc.Inventor: A. Arthur Gottlieb
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Patent number: 4778750Abstract: A diagnostic test is described for the assay of human and animal immune system response, in vitro. The test measures production in a peripheral blood lymphocyte population of a material that is an index of mitogen-induced immune response. Adaptations of the test are provided for the titration of amplifier dosage, and for a determination whether amplifier treatment is warranted for immunodeficient patients such as those with AIDS or ARC.Type: GrantFiled: February 19, 1986Date of Patent: October 18, 1988Assignee: Imreg, Inc.Inventor: A. Arthur Gottlieb
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Patent number: 4751216Abstract: Methods are disclosed for the treatment of Acquired Immune Deficiency Syndrome (AIDS) and AIDS-Related Complex (ARC) by administering injections of Tyr-Gly-Gly and derivatives thereof.Type: GrantFiled: July 16, 1987Date of Patent: June 14, 1988Assignee: Imreg, Inc.Inventor: A. Arthur Gottlieb
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Patent number: 4710380Abstract: Therapeutic methods for treatment of rheumatoid arthritis, lupis, Type I diabetes, and other autoimmune disorders are described wherein amplifiers of the immune system response are administered to the subject. Instead of further increasing the hyperactive immune response, however, administering the amplifiers has the effect of reducing the excessive immune responsiveness. Compositions for such administration are also described.Type: GrantFiled: April 4, 1986Date of Patent: December 1, 1987Assignee: Imreg, Inc.Inventor: A. Arthur Gottlieb
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Patent number: 4699898Abstract: A tripeptide and derivatives thereof are described that amplify mammalian immune response. A purification process, methods of using, and pharmaceutical compositions for using the product are disclosed.Type: GrantFiled: December 26, 1985Date of Patent: October 13, 1987Assignee: Imreg, Inc.Inventor: A. Arthur Gottlieb
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Patent number: 4616079Abstract: A high pressure liquid chromatography process is described for the extraction of materials that nonspecifically amplify the immune response to antigens to which the subject was previously or is concomitantly exposed. The materials are also described, as are methods and compositions for the use thereof in connection with hypoimmune conditions.Type: GrantFiled: August 24, 1984Date of Patent: October 7, 1986Assignee: Imreg, Inc.Inventor: A. Arthur Gottlieb
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Patent number: 4490472Abstract: An improved, more convenient, more sensitive test for detection of certain malignancies in human and animal subjects is disclosed. Sera from test subjects is mixed with labeled DNA in the presence of an enzyme-conjugated resin. Sera from normal and cancerous subjects react differently with the resin, permitting a diagnosis of the subject.Type: GrantFiled: June 17, 1982Date of Patent: December 25, 1984Assignee: Imreg, Inc.Inventor: A. Arthur Gottlieb