Patents Assigned to Imreg, Inc.
  • Tyr-Gly compositions useful in increasing immune response
    Patent number: 5100663
    Abstract: Compositions for delaying the progression from AIDS to ARC, and for alleviating symptoms of AIDS and ARC are disclosed together with clinical results of use of such compositions in clinical trials with of actual human patients suffering from these diseases. The compositions are based on a Tyr-Gly amino acid residue sequence. Typical dosage amounts are in the range of femtomoles/kg of body weight.
    Type: Grant
    Filed: January 24, 1990
    Date of Patent: March 31, 1992
    Assignee: Imreg, Inc.
    Inventor: A. Arthur Gottlieb
  • Dialysates for treating aids and arc and for otherwise increasing immune response
    Patent number: 5093321
    Abstract: Purified human leukocyte dialysates are described for treatment of AIDS, ARC, and other immunodeficient conditions. The dialysates are purified by HPLC processes, and are made available in a form that is free of endotoxin and pyrogen. A dialysate designated Beta-1.11 is found by amino acid sequencing to consist essentially of endogenous Tyr-Gly. A dialysate designated Beta-1.12 is found by amino acid sequencing to consist essentially of endogenous Tyr-Gly-Gly.
    Type: Grant
    Filed: January 24, 1990
    Date of Patent: March 3, 1992
    Assignee: Imreg, Inc.
    Inventor: A. A. Gottlieb
  • Method of showing progression of AIDS in an ARC patient by treating with Tyr-Gly compositions
    Patent number: 5081108
    Abstract: Purified human leukocyte dialysates are described for treatment of AIDS, ARC, and other immunodeficient conditions. The dialysates are purified by HPLC processes, and are made available in a form that is free of endotoxin and pyrogen. Methods are described for slowing the progression from ARC to AIDS and for alleviating symptoms of AIDS and ARC, by administration of the dialysates. Methods for treating candidiasis and for increasing immune system response to recall antigen, by administration of the dialysates, are also described.
    Type: Grant
    Filed: January 24, 1990
    Date of Patent: January 14, 1992
    Assignee: Imreg, Inc.
    Inventor: A. Arthur Gottlieb
  • Methods for modulating antibody production in treating patients with AIDS, ARC and other diseases
    Patent number: 5013546
    Abstract: Methods and compositions are described for increasing and decreasing immunoglobulin production by administering to a human or other mammalian subject an appropriate dosage of amplifier. Administration of amplifier to subjects having excessive production of immunoglobulin, namely AIDS and ARC patients, is shown as decreasing such excessive immunoglobulin production in such patients.
    Type: Grant
    Filed: March 29, 1990
    Date of Patent: May 7, 1991
    Assignee: Imreg, Inc.
    Inventors: A. Arthur Gottlieb, Robert C. Sizemore
  • Immunosuppressor and method of extraction thereof from leukocytes
    Patent number: 4920097
    Abstract: Methods of extracting an immunosuppressor from leukocyte dialysates are disclosed, together with methods for using the immunosuppressor and compositions containing the immunosuppressor.
    Type: Grant
    Filed: October 12, 1988
    Date of Patent: April 24, 1990
    Assignee: Imreg, Inc.
    Inventors: A. Arthur Gottlieb, Robert C. Sizemore, Sudhir K. Sinha
  • Therapeutic method for treating malignancies
    Patent number: 4874608
    Abstract: A method is described for treating mammalian solid tumors by administering leukocyte-derived amplifiers of the immune system to tumor-bearing subjects. The amplifiers include Beta-1.0, Beta-1.1, Beta-1,12, TG, and TGG.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: October 17, 1989
    Assignee: Imreg, Inc.
    Inventor: A. Arthur Gottlieb
  • Diagnostic methods for immune function
    Patent number: 4778750
    Abstract: A diagnostic test is described for the assay of human and animal immune system response, in vitro. The test measures production in a peripheral blood lymphocyte population of a material that is an index of mitogen-induced immune response. Adaptations of the test are provided for the titration of amplifier dosage, and for a determination whether amplifier treatment is warranted for immunodeficient patients such as those with AIDS or ARC.
    Type: Grant
    Filed: February 19, 1986
    Date of Patent: October 18, 1988
    Assignee: Imreg, Inc.
    Inventor: A. Arthur Gottlieb
  • Methods for treating AIDS and ARC
    Patent number: 4751216
    Abstract: Methods are disclosed for the treatment of Acquired Immune Deficiency Syndrome (AIDS) and AIDS-Related Complex (ARC) by administering injections of Tyr-Gly-Gly and derivatives thereof.
    Type: Grant
    Filed: July 16, 1987
    Date of Patent: June 14, 1988
    Assignee: Imreg, Inc.
    Inventor: A. Arthur Gottlieb
  • Treatment of autoimmune disorders with immunoamplifiers
    Patent number: 4710380
    Abstract: Therapeutic methods for treatment of rheumatoid arthritis, lupis, Type I diabetes, and other autoimmune disorders are described wherein amplifiers of the immune system response are administered to the subject. Instead of further increasing the hyperactive immune response, however, administering the amplifiers has the effect of reducing the excessive immune responsiveness. Compositions for such administration are also described.
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: December 1, 1987
    Assignee: Imreg, Inc.
    Inventor: A. Arthur Gottlieb
  • Tripeptides affecting immune response
    Patent number: 4699898
    Abstract: A tripeptide and derivatives thereof are described that amplify mammalian immune response. A purification process, methods of using, and pharmaceutical compositions for using the product are disclosed.
    Type: Grant
    Filed: December 26, 1985
    Date of Patent: October 13, 1987
    Assignee: Imreg, Inc.
    Inventor: A. Arthur Gottlieb
  • Immunoamplifiers and processes for the extraction thereof
    Patent number: 4616079
    Abstract: A high pressure liquid chromatography process is described for the extraction of materials that nonspecifically amplify the immune response to antigens to which the subject was previously or is concomitantly exposed. The materials are also described, as are methods and compositions for the use thereof in connection with hypoimmune conditions.
    Type: Grant
    Filed: August 24, 1984
    Date of Patent: October 7, 1986
    Assignee: Imreg, Inc.
    Inventor: A. Arthur Gottlieb
  • Sensitive tests for malignancies based on DNA detection
    Patent number: 4490472
    Abstract: An improved, more convenient, more sensitive test for detection of certain malignancies in human and animal subjects is disclosed. Sera from test subjects is mixed with labeled DNA in the presence of an enzyme-conjugated resin. Sera from normal and cancerous subjects react differently with the resin, permitting a diagnosis of the subject.
    Type: Grant
    Filed: June 17, 1982
    Date of Patent: December 25, 1984
    Assignee: Imreg, Inc.
    Inventor: A. Arthur Gottlieb